Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alice Piapi"'
Autor:
Gerda Kildisiute, Maria Kalyva, Rasa Elmentaite, Stijn van Dongen, Christine Thevanesan, Alice Piapi, Kirsty Ambridge, Elena Prigmore, Muzlifah Haniffa, Sarah A. Teichmann, Karin Straathof, Isidro Cortés-Ciriano, Sam Behjati, Matthew D. Young
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background As normal cells transform into cancers, their cell state changes, which may drive cancer cells into a stem-like or more primordial, foetal, or embryonic cell state. The transcriptomic profile of this final state may encode informa
Externí odkaz:
https://doaj.org/article/812f3b2924404e51948b8b5e13fcb34b
Autor:
Mi K. Trinh, Clarissa N. Pacyna, Gerda Kildisiute, Christine Thevanesan, Alice Piapi, Kirsty Ambridge, Nathaniel D. Anderson, Eleonora Khabirova, Elena Prigmore, Karin Straathof, Sam Behjati, Matthew D. Young
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
The identification of cancer cells from single cell transcriptomes can be improved by detecting allelic imbalances due to copy number changes.
Externí odkaz:
https://doaj.org/article/220e9b9e0e1441249c0e227b1bf2a3ec
Autor:
Alastair Hotblack, Evangelia K. Kokalaki, Morgan J. Palton, Gordon Weng-Kit Cheung, Iwan P. Williams, Somayya Manzoor, Thomas I. Grothier, Alice Piapi, Valeria Fiaccadori, Patrycja Wawrzyniecka, Harriet A. Roddy, Giulia Agliardi, Claire Roddie, Shimobi Onuoha, Simon Thomas, Shaun Cordoba, Martin Pule
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Chimeric antigen receptor (CAR) T cells are a promising form of cancer immunotherapy, although they are often associated with severe toxicities. Here, we present a split-CAR design incorporating separate antigen recognition and intracellular
Externí odkaz:
https://doaj.org/article/dee4a8da64cb4a34bd085ebded529484
Autor:
Matthew D. Young, Thomas J. Mitchell, Lars Custers, Thanasis Margaritis, Francisco Morales-Rodriguez, Kwasi Kwakwa, Eleonora Khabirova, Gerda Kildisiute, Thomas R. W. Oliver, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Federico Comitani, Alice Piapi, Eva Bugallo-Blanco, Christine Thevanesan, Christina Burke, Elena Prigmore, Kirsty Ambridge, Kenny Roberts, Felipe A. Vieira Braga, Tim H. H. Coorens, Ignacio Del Valle, Anna Wilbrey-Clark, Lira Mamanova, Grant D. Stewart, Vincent J. Gnanapragasam, Dyanne Rampling, Neil Sebire, Nicholas Coleman, Liz Hook, Anne Warren, Muzlifah Haniffa, Marcel Kool, Stefan M. Pfister, John C. Achermann, Xiaoling He, Roger A. Barker, Adam Shlien, Omer A. Bayraktar, Sarah A. Teichmann, Frank C. Holstege, Kerstin B. Meyer, Jarno Drost, Karin Straathof, Sam Behjati
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dediff
Externí odkaz:
https://doaj.org/article/07a679f9a06e4d84ac2da9b571bfc2a4
Autor:
Gerda Kildisiute, Maria Kalyva, Rasa Elmentaite, Stijn van Dongen, Christine Thevanesan, Alice Piapi, Kirsty Ambridge, Elena Prigmore, Muzlifah Haniffa, Sarah A. Teichmann, Karin Straathof, Isidro Cortés-Ciriano, Sam Behjati, Matthew D. Young
As normal cells transform into cancers, their cell state changes (or “dedifferentiates”), which may drive cancer cells into a stem-like or more primordial, foetal or embryonic cell state. Here, we used single cell atlases to study dedifferentiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fde57ebc1738ad6ce297a35ed10463b4
https://doi.org/10.1101/2022.11.28.518191
https://doi.org/10.1101/2022.11.28.518191
Autor:
Jennifer C Chandler, Daniyal J Jafree, Saif Malik, Gideon Pomeranz, Mary Ball, Maria Kolatsi-Joannou, Alice Piapi, William J Mason, Adrian S Woolf, Paul J Winyard, Andrew S Mason, Aoife M Waters, David A Long
The glomerulus mediates kidney ultrafiltration through specialised epithelial cells called podocytes which line a basement membrane shared with blood capillary endothelium. Cell-cell crosstalk is critical for glomerular function, but its investigatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd892f6ea94290d55411e1ad6c449c61
https://doi.org/10.1101/2022.10.11.511555
https://doi.org/10.1101/2022.10.11.511555
Autor:
Eleonora Khabirova, Laura Jardine, Tim H. H. Coorens, Simone Webb, Taryn D. Treger, Justin Engelbert, Tarryn Porter, Elena Prigmore, Grace Collord, Alice Piapi, Sarah A. Teichmann, Sarah Inglott, Owen Williams, Olaf Heidenreich, Matthew D. Young, Karin Straathof, Simon Bomken, Jack Bartram, Muzlifah Haniffa, Sam Behjati
Funder: Lister Institute of Preventive Medicine; doi: https://doi.org/10.13039/501100001255
Funder: Newcastle NIHR-Biomedical Research Centre
KMT2A-rearranged infant ALL is an aggressive childhood leukemia with poor prognosis. Here, we inve
Funder: Newcastle NIHR-Biomedical Research Centre
KMT2A-rearranged infant ALL is an aggressive childhood leukemia with poor prognosis. Here, we inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd33f1816816ca4a0632e3173b9c068
https://www.repository.cam.ac.uk/handle/1810/336209
https://www.repository.cam.ac.uk/handle/1810/336209
Autor:
Eleonora Khabirova, Laura Jardine, Tim H. H. Coorens, Simone Webb, Taryn D. Treger, Justin Englebert, Tarryn Porter, Elena Prigmore, Grace Collord, Alice Piapi, Sarah Teichmann, Sarah Inglott, Owen Williams, Olaf Heidenreich, Matthew D. Young, Karin Straathof, Simon Bomken, Jack Bartram, Muzlifah Haniffa, Sam Behjati
Infant B-cell acute lymphoblastic leukemia (B-ALL) has not followed the increasing trend towards cure seen in other childhood B-ALLs. The prognosis for infants with KMT2A gene fusions is especially poor, and the origins of this aggressive leukemia re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f6323db91aa8134a71a7b5b8af4f9ad
https://doi.org/10.1101/2021.12.17.473141
https://doi.org/10.1101/2021.12.17.473141
Autor:
Valeria Fiaccadori, Morgan J. Palton, Evangelia Kokalaki, Shaun Cordoba, Harriet Roddy, Shimobi Onuoha, Gordon Cheung, Iwan P. Williams, Claire Roddie, Alastair Hotblack, Giulia Agliardi, Thomas Grothier, Martin Pule, Patrycja Wawrzyniecka, Somayya Manzoor, Simon Thomas, Alice Piapi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Chimeric antigen receptor (CAR) T cells are a promising form of cancer immunotherapy, although they are often associated with severe toxicities. Here, we present a split-CAR design incorporating separate antigen recognition and intracellular signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b626e2d4885c15c9174b1477fc8d8a0a
https://pubmed.ncbi.nlm.nih.gov/34754016
https://pubmed.ncbi.nlm.nih.gov/34754016
Autor:
Michelle L. Tas, Eleonora Khabirova, Christina Burke, Gerda Kildisiute, Giuseppe Barone, Matthew D. Young, Karin Straathof, Omer Ali Bayraktar, Waleed M. Kholosy, Clarissa N. Pacyna, Sam Behjati, Rasa Elmentaite, Xiaoling He, Philip Lijnzaad, Marc H. W. A. Wijnen, John C. Achermann, Ignacio del Valle, Eva Bugallo-Blanco, Kerstin B. Meyer, Ronald R. de Krijger, Alice Piapi, Thanasis Margaritis, Muzlifah Haniffa, Lira Mamanova, Karin P.S. Langenberg-Ververgaert, Dyanne Rampling, Max M. van Noesel, Frank C. P. Holstege, Kenny Roberts, John Anderson, Roger A. Barker, Sarah A. Teichmann, Sander R. van Hooff, Kaylee M. Keller, Neil J. Sebire, Christine Thevanesan, Reinier van der Linden, Catriona Duncan, Jan J. Molenaar
Publikováno v:
Science advances, 7(6), 1. American Association for the Advancement of Science
Science Advances
Science Advances
Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest. It is not established what developmental processes neuroblastoma cancer cells represent. Here, we sought to reveal the phenotype of neuroblastoma cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e8b940f5b241956fe725bfb610727a
https://dspace.library.uu.nl/handle/1874/412169
https://dspace.library.uu.nl/handle/1874/412169