Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Alice N. McEvoy"'
1
Increased Expression of the Orphan Nuclear Receptor NURR1 in Psoriasis and Modulation following TNF-α Inhibition
Autor: Alice N. McEvoy, DJ Veale, Brian Kirby, Marina O'Kane, Trevor Markham, Oliver FitzGerald, Ursula Fearon, Evelyn P. Murphy
Publikováno v: Journal of Investigative Dermatology. 128(2):300-310
The orphan nuclear receptor NURR1 belongs to the NR4A subfamily of transcription factors which are emerging as important mediators of cytokine and growth factor signaling. The transcriptional function of these ligand-independent and constitutively ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d52f86fea91fe3a9970e1764384579
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2
Tumour necrosis factor-α (TNF-α) increases nuclear factor κB (NFκB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells
Autor: L. Lillis, David E. MacHugh, Evelyn P. Murphy, Alice N. McEvoy, Kieran G. Meade, Alan W. Baird, Denise C. Fitzgerald
Publikováno v: Veterinary Immunology and Immunopathology. 116:59-68
Epithelia play important immunological roles at a variety of mucosal sites. We examined NFκB activity in control and TNF-α treated bovine mammary epithelial monolayers (BME-UV cells). A region of the bovine IL-8 (bIL-8) promoter was sequenced and a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d82783e531bd4f2a9620ee6aec79d53f
https://doi.org/10.1016/j.vetimm.2006.12.008
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3
Involvement of MAPKs in Endostatin-Mediated Regulation of Blood-Retinal Barrier Function
Autor: Alice N. McEvoy, Ross F Collery, Tom A. Gardiner, Alan W. Stitt, Matthew Campbell, Brenda Brankin
Publikováno v: Current Eye Research. 31:1033-1045
This study aimed to evaluate the effects of endostatin on tight junction (TJ) integrity in retinal microvascular endothelial cells (RMECs) in vitro and in vivo. Moreover, it was hypothesized that endostatin-induced occludin upregulation regulated VEG
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63360f383f458aaf846a0f7e66aadd8
https://doi.org/10.1080/02713680601013025
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4
Cyclooxygenase 2-derived prostaglandin E2 production by corticotropin-releasing hormone contributes to the activated cAMP response element binding protein content in rheumatoid arthritis synovial tissue
Autor: Barry Bresnihan, Evelyn P. Murphy, Alice N. McEvoy, Oliver FitzGerald
Publikováno v: Arthritis & Rheumatism. 50:1132-1145
Objective To determine a mechanism by which corticotropin-releasing hormone (CRH) promotes human inflammatory joint disease progression. Methods An ex vivo synovial tissue culture system was established to investigate the functional properties of CRH
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615c4c6e999c38a19bfa0e3754845320
https://doi.org/10.1002/art.20157
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5
Corticotropin-releasing hormone signaling in synovial tissue from patients with early inflammatory arthritis is mediated by the type 1? corticotropin-releasing hormone receptor
Autor: Alice N. McEvoy, Evelyn P. Murphy, Oliver FitzGerald, Barry Bresnihan
Publikováno v: Arthritis & Rheumatism. 44:1761-1767
Objective Elevated levels of corticotropin-releasing hormone (CRH) are produced locally in inflamed human synovial tissue, and previous observations indicate a role for CRH in the pathogenesis of inflammatory joint disease. To further elucidate the b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eecab3c6a54e88143d598affecfde8d4
https://doi.org/10.1002/1529-0131(200108)44:8<1761::aid-art311>3.0.co
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7
Histamine contributes to increased RANKL to osteoprotegerin ratio through altered nuclear receptor 4A activity in human chondrocytes
Autor: Viviana Marzaioli, Martin H Stradner, Alyssa Gilmore, Martina Gogarty, Evelyn P. Murphy, Jason P. McMorrow, Peadar Rooney, Alice N. McEvoy, Davide Zocco, Douglas J. Veale, Ursula Fearon, Daniel Crean, H. Angerer
Publikováno v: Arthritis and rheumatism. 64(10)
Objective To elucidate histamine receptor–mediated signaling pathways, transcriptional events, and target gene expression in human cartilage. Methods Histamine modulation of cartilage destruction was assessed by Safranin O staining and proteoglycan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5eb55c38c28d0ef509ed90db994fae
https://pubmed.ncbi.nlm.nih.gov/22674155
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8
Modulation of orphan nuclear receptor NURR1 expression by methotrexate in human inflammatory joint disease involves adenosine A2A receptor-mediated responses
Autor: David Kane, Alice N. McEvoy, Evelyn P. Murphy, Jennifer A. Ralph, Barry Bresnihan, Oliver FitzGerald
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 175(1)
Modulation by proinflammatory mediators indicate that NURR1 induction represents a point of convergence of distinct signaling pathways, suggesting an important common role for this transcription factor in mediating multiple inflammatory signals. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f201c4b2c055fba9d8a40e739ea26510
https://pubmed.ncbi.nlm.nih.gov/15972692
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9
Corticotropin-releasing hormone signaling in synovial tissue vascular endothelium is mediated through the cAMP/CREB pathway
Autor: Barry Bresnihan, Evelyn P. Murphy, Alice N. McEvoy, Oliver FitzGerald
Publikováno v: Annals of the New York Academy of Sciences. 966
Modulation of locally produced corticotropin-releasing hormone (CRH) is a component of the cytokine network in human inflammatory arthritis. CRH signaling, through the CRH-receptor subtype R1alpha, may play a role in both vascular changes and patholo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8187aa3b3dc5ba455a76a9be98269094
https://pubmed.ncbi.nlm.nih.gov/12114266
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10
Activation of nuclear orphan receptor NURR1 transcription by NF-kappa B and cyclic adenosine 5'-monophosphate response element-binding protein in rheumatoid arthritis synovial tissue
Autor: Alice N. McEvoy, Orla M. Conneely, Tiia Ponnio, Barry Bresnihan, Oliver FitzGerald, Evelyn P. Murphy, E. Murphy
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 168(6)
Modulation of the NURR subfamily of nuclear receptors may be an important mechanism regulating pathways associated with inflammatory joint disease. We examined the signaling mechanisms through which inflammatory mediators, produced by rheumatoid arth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42248c76a1ac208c7e122809b66a5116
https://pubmed.ncbi.nlm.nih.gov/11884470
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