Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Alice Melão"'
1
Akademický článek
Factors Related with Adiponectinemia in Obese and Normal-Weight Women and with Its Variation in Weight Loss Programs
Autor: José Silva-Nunes, Ana Oliveira, Leone Duarte, Margarida Barradas, Alice Melão, Miguel Brito, Luisa Veiga
Publikováno v: Obesity Facts, Vol 6, Iss 2, Pp 124-133 (2013)
Objective: To assess different factors influencing adiponectinemia in obese and normal-weight women; to identify factors associated with the variation (Δ) in adiponectinemia in obese women following a 6-month weight loss program, according to surgic
Externí odkaz: https://doaj.org/article/43c5e6dedfb84adca972e5a0e93dcce5
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2
Akademický článek
Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity
Autor: Alice Melão, Maureen Spit, Bruno A. Cardoso, João T. Barata
Publikováno v: Haematologica, Vol 101, Iss 11 (2016)
Interleukin-7 and interleukin-7 receptor are essential for normal T-cell development and homeostasis, whereas excessive interleukin-7/interleukin-7 receptor-mediated signaling promotes leukemogenesis. The protein kinase, casein kinase 2, is overexpre
Externí odkaz: https://doaj.org/article/ccfa483d02344d67abd8c76fc34181a7
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3
Akademický článek
Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels
Autor: A. Margarida Gomes, Maria V. D. Soares, Patrícia Ribeiro, Joana Caldas, Vanda Póvoa, Leila R. Martins, Alice Melão, Ana Serra-Caetano, Aida B. de Sousa, João F. Lacerda, João T. Barata
Publikováno v: Haematologica, Vol 99, Iss 6 (2014)
Adult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring a better characterization of the molecular determinants underlying disease progression and resistance to treatment. Here, using a phospho-flow cytometry approa
Externí odkaz: https://doaj.org/article/b37f688fffe14b2992230b6ab3847ecd
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4
IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update
Autor: João T. Barata, Daniel Dias Ribeiro, Padma Akkapeddi, Mariana L. Oliveira, Alice Melão
Publikováno v: Advances in Biological Regulation
© 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)
Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae02e04d5b8a370b30e8a4993a528ea
https://doi.org/10.1016/j.jbior.2018.09.012
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5
STAT5 is essential for IL-7–mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells
Autor: Ruben van Boxtel, Paul J. Coffer, Bruno A. Cardoso, Alice Melão, Milene Costa da Silva, Daniel Dias Ribeiro, Cristina Santos, Ana Elisa Bauer de Camargo Silva, João T. Barata
Publikováno v: Blood Advances
Blood Advances, 2(17), 2199. The American Society of Hematology
T-cell acute lymphoblastic leukemia (T-ALL) constitutes an aggressive subset of ALL, the most frequent childhood malignancy. Whereas interleukin-7 (IL-7) is essential for normal T-cell development, it can also accelerate T-ALL development in vivo and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfc9c50e679fc64928c3f77ce3b0ee4
https://doi.org/10.1182/bloodadvances.2018021063
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6
Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity
Autor: Bruno A. Cardoso, João T. Barata, Alice Melão, Maureen Spit
Publikováno v: Haematologica
Interleukin-7 and interleukin-7 receptor are essential for normal T-cell development and homeostasis, whereas excessive interleukin-7/interleukin-7 receptor-mediated signaling promotes leukemogenesis. The protein kinase, casein kinase 2, is overexpre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37637086b954a2aec7ed204ee5c356b
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7
IL-7 Activates a STAT5/PIM1 Axis to Promote T-Cell Acute Lymphoblastic Leukemia Proliferation and Viability in a Bcl-2-Independent Manner
Autor: Ruben van Boxtel, Ribeiro Daniel, Alice Melão, Ana Elisa Bauer de Camargo Silva, Milene Costa da Silva, Bruno A. Cardoso, João T. Barata, Paul J. Coffer, Cristina Santos
Publikováno v: Blood. 132:914-914
Background: T-cell acute lymphoblastic leukemia (T-ALL) constitutes an aggressive subset of ALL, the most frequent childhood malignancy. Although risk-adjusted chemotherapeutic regimens are currently extremely effective, their efficacy is associated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4afd2d498f79c8bc40fa38c3a3f32a30
https://doi.org/10.1182/blood-2018-99-113778
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8
Adult B-Cell Acute Lymphoblastic Leukemia Cells Display Decreased PTEN Activity and Constitutive Hyperactivation of PI3K/Akt Pathway Despite High PTEN Protein Levels
Autor: João T. Barata, Ana Serra-Caetano, Alice Melão, A. Margarida Gomes, Vanda Póvoa, Patrícia Ribeiro, Aida Botelho de Sousa, Leila R. Martins, Maria V. D. Soares, João F. Lacerda, Joana Caldas
Publikováno v: Haematologica
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
© 2014 Ferrata Storti Foundation. This is an open-access paper
Adult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring a better characterization of the molecular determinants underlying disease progression and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62666ba477c99e96e8d4eee25796cdf6
https://hdl.handle.net/10400.17/2464
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10
IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia
Autor: João T. Barata, Daniel Dias Ribeiro, Alice Melão
Publikováno v: Advances in Biological Regulation
Interleukin-7 (IL-7), a cytokine produced in the bone marrow, thymus and other organs, is mandatory for normal human T-cell development and peripheral homeostasis. Different studies, including phase I clinical trials, have indicated the potential the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b47cb5e524d38c3d5856d2f6cd2e31
https://pubmed.ncbi.nlm.nih.gov/23234870
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