High SARS-CoV-2 seroprevalence in health care workers but relatively low numbers of deaths in urban Malawi [version 2; peer review: 2 approved]

Autor: Marah G. Chibwana, Khuzwayo C. Jere, Raphael Kamng'ona, Jonathan Mandolo, Vincent Katunga-Phiri, Dumizulu Tembo, Ndaona Mitole, Samantha Musasa, Simon Sichone, Agness Lakudzala, Lusako Sibale, Prisca Matambo, Innocent Kadwala, Rachel L. Byrne, Alice Mbewe, Marc Y. R. Henrion, Ben Morton, Chimota Phiri, Jane Mallewa, Henry C. Mwandumba, Emily R. Adams, Stephen B. Gordon, Kondwani C. Jambo

Publikováno v: Wellcome Open Research, Vol 5 (2020)

Background: In low-income countries, like Malawi, important public health measures including social distancing or a lockdown have been challenging to implement owing to socioeconomic constraints, leading to predictions that the COVID-19 pandemic woul

Externí odkaz: https://doaj.org/article/acbac3b0ac754e799ea932537edd276d

High SARS-CoV-2 seroprevalence in Health Care Workers but relatively low numbers of deaths in urban Malawi

Autor: Dumizulu L. Tembo, Ben Morton, Rachel L Byrne, Vincent Katunga-Phiri, Henry C. Mwandumba, Samantha Musasa, Chimota Phiri, Raphael Kamng'ona, Marah Grace Chibwana, Simon Sichone, Khuzwayo C. Jere, Jane Mallewa, Marc Henrion, Emily R. Adams, Kondwani C. Jambo, Ndaona Mitole, Alice Mbewe, Innocent Kadwala, Lusako Sibale, Stephen B. Gordon, Agness Lakudzala, Jonathan Mandolo, Prisca Matambo

BackgroundIn low-income countries, like Malawi, important public health measures including social distancing or a lockdown, have been challenging to implement owing to socioeconomic constraints, leading to predictions that the COVID-19 pandemic would

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45370f16ea1c438302e89072b233a03c
https://doi.org/10.1101/2020.07.30.20164970

Optimizing delivery of HIV-1 conserved region-derived immunogen for induction of T and B cell responses in rhesus macaques

Autor: Alice Mbewe-Mvula, C. J. Melief, David Price, G Koopman, JW Drijfhout, Tomáš Hanke, P. Liljestrom, R Wagner, E. D. Quakkelaar, Nicola Borthwick, S. Colloca, Maximillian Rosario, ML Knudsen, A. Nicosia

Publikováno v: Retrovirology
ResearcherID

Background The complexity of candidate HIV-1 vaccine formulations is increasing due to extreme challenges faced when trying to prevent or control HIV-1 infection. Methods Immunogen HIVconsv based on the most conserved regions of the HIV-1 proteome wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b71aa4e4667ef193fa5ca3ccd6ed94d
https://ora.ox.ac.uk/objects/uuid:eb2a0ab9-0d22-403d-8bf0-98957d0d8adb

Superior induction of T cell responses to conserved HIV-1 regions by electroporated alphavirus replicon DNA compared to that with conventional plasmid DNA vaccine

Autor: Maria Kakoulidou, Alfredo Nicosia, Peter Liljeström, Maximillian Rosario, Alice Mbewe-Mvula, Anne Bridgeman, Tomáš Hanke, Maria L. Knudsen, Daniel X. Johansson, Karl Ljungberg, Arturo Reyes-Sandoval

Publikováno v: Journal of Virology

Vaccination using “naked” DNA is a highly attractive strategy for induction of pathogen-specific immune responses; however, it has been only weakly immunogenic in humans. Previously, we constructed DNA-launched Semliki Forest virus replicons (DRE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd899790819fc21523834dedf82abef2
http://hdl.handle.net/11588/571659

Pre-clinical development of BCG.HIVA(CAT), an antibiotic-free selection strain, for HIV-TB pediatric vaccine vectored by lysine auxotroph of BCG

Autor: Narcís Saubi, Maximillian Rosario, Ester Gea-Mallorquí, Joan Joseph, Tomáš Hanke, Josep M. Gatell, Alice Mbewe-Mvula

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e42559 (2012)

In the past, we proposed to develop a heterologous recombinant BCG prime-recombinant modified vaccinia virus Ankara (MVA) boost dual pediatric vaccine platform against transmission of breast milk HIV-1 and Mycobacterium tuberculosis (Mtb). In this st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffe0a00d2d355617e9cd77ecbe9f877
http://hdl.handle.net/2445/124795