Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alice M.-F. Laures"'
Autor:
Janice Fernandez, Andrew Read, Zheng Pu, Antonio Raul Ubiera, Alice M.-F. Laures, Diana Ritz, Isaiah Aguilar, Yang Liu, Pramthesh Patel, Kevin Lan, Li Cao, Robert G. Luo, Aston Liu, Alison Smith, Hong Zhang
Publikováno v:
Journal of Pharmaceutical Sciences. 109:3319-3329
In response to the FDA's call for applying Quality by Design (QbD) to the manufacturing process, the biopharmaceutical industry has invested extensively into the monitoring and controlling of product quality attributes for bioprocesses. To assure the
Publikováno v:
Rapid communications in mass spectrometry : RCMREFERENCES.
Rationale Rapid Evaporative Ionisation Mass Spectrometry (REIMS) has been evaluated as a tool to improve analytical efficiency and add capability in areas within Pharmaceutical Research and Development (Pharma R&D). This article reports the compariso
Publikováno v:
International Journal of Mass Spectrometry. 298:72-77
The effect of drift gas and binary gas mixtures on the separation of active pharmaceutical ingredients and related compounds has been investigated for the first time using tri-wave ion mobility–mass spectrometry. The drift times for [M+H]+ ions wer
Autor:
Phil J. Borman, Jean-Claude Wolff, Mark Harrison, Alice M.-F. Laures, Marion J. Chatfield, James T. Kapron, Elodie Champarnaud
Publikováno v:
Rapid Communications in Mass Spectrometry. 23:181-193
For the determination of trace level impurities, analytical chemists are confronted with complex mixtures and difficult separations. New technologies such as high-field asymmetric waveform ion mobility spectrometry (FAIMS) have been developed to make
Publikováno v:
Journal of the American Society for Mass Spectrometry. 20:1-9
Gas-phase ion mobility studies of mixtures containing polyethylene glycols (PEG) and an active pharmaceutical ingredient (API), lamivudine, have been carried out using electrospray ionization-ion mobility spectrometry-quadrupole-time-of-flight mass s
Publikováno v:
Rapid Communications in Mass Spectrometry. 21:2415-2421
Time-of-flight mass spectrometry (ToF-MS) has gained wide acceptance in many fields of chemistry, proteomics, metabolomics and small molecule analysis. ToF-MS, however, has some inherent advantages and drawbacks. Numerous developments have been made
Publikováno v:
Rapid Communications in Mass Spectrometry. 21:1255-1263
Many formulated products contain complex polymeric excipients such as polyethylene glycols (PEGs). Such excipients can be readily ionized by electrospray and may be present at very high concentrations, thus making it very difficult to identify trace
Publikováno v:
Rapid Communications in Mass Spectrometry. 21:529-535
The results of an investigation of the parameters which have the most significant effect on the accuracy of mass measurements on a quadrupole orthogonal acceleration time-of-flight mass spectrometer (q-oaToF) are reported. The influence of eight fact
Autor:
Jean-Claude Wolff, Alice M.-F. Laures
Publikováno v:
Rapid Communications in Mass Spectrometry. 20:3769-3779
In-source 'on-the-fly' hydrogen/deuterium (H/D) exchange liquid chromatography mass spectrometry (LC/MS) has been investigated. The work was performed using a dual-sprayer source. The analyte was introduced through an electrospray ionisation sprayer
Autor:
Scott W. Francey, Marion J. Chatfield, Alice M.-F. Laures, Phil J. Borman, David P. Elder, Jean-Claude Wolff, Elizabeth L. Crowley, Christine Eckers
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 48(4)
This work describes the development of a liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for a highly toxic impurity, FMTP (4-(4-fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine), in paroxetine active pharmaceutical ingredient (API),