Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alice M. Symons"'
Autor:
P. Dan Cook, George Minasov, Valentina Tereshko, Marianna Teplova, Alice M. Symons, Martin Egli, Muthiah Manoharan, S.T. Wallace
Publikováno v:
Proceedings of the National Academy of Sciences. 96:14240-14245
Nuclease resistance and RNA affinity are key criteria in the search for optimal antisense nucleic acid modifications, but the origins of the various levels of resistance to nuclease degradation conferred by chemical modification of DNA and RNA are cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e097fa8d4f018671412eb02ef6ffae5
https://doi.org/10.1073/pnas.96.25.14240
https://doi.org/10.1073/pnas.96.25.14240
Publikováno v:
ChemInform. 30
We introduce a novel approach to incorporate 2-aminoadenosine into oligonucleotides in which 2-fluoroadenosine and its derivatives are used to prepare the monomers and, under normal oligonucleotide deprotection conditions, is converted to the desired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cec005515fc43d3e2fcc7019d9e3937
https://doi.org/10.1002/chin.199943227
https://doi.org/10.1002/chin.199943227
Autor:
Ohashi Ct, Lex M. Cowsert, Phillip Dan Cook, Muthiah Manoharan, Balkrishen Bhat, Peoc'h D, Alice M. Symons
Publikováno v:
Nucleosidesnucleotides. 18(6-7)
Phosphorothioate antisense oligodeoxyribonucleotides (PS-ASOs) have proven to be useful first generation antisense tools for in vitro and in vivo uses and now show great promise as human therapeutic agents. However, there are two characteristics of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298e4db2b9c522d8def4092609bbafb4
https://pubmed.ncbi.nlm.nih.gov/10474224
https://pubmed.ncbi.nlm.nih.gov/10474224
Publikováno v:
Nucleosides and Nucleotides. 18:1203-1204
We introduce a novel approach to incorporate 2-aminoadenosine into oligonucleotides in which 2-fluoroadenosine and its derivatives are used to prepare the monomers and, under normal oligonucleotide deprotection conditions, is converted to the desired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92c7846a346ba45e01f942c9faef813e
https://doi.org/10.1080/07328319908044662
https://doi.org/10.1080/07328319908044662
Autor:
Hirobumi Kishioka, Chikara Satoh, Alice M. Symons, Muthiah Manoharan, Noboru Fukuda, Katsuo Kanmatsuse, Wen Yang Hu, Balkrishen Bhat, Mari Nakayama
Publikováno v:
European Journal of Pharmacology. 404:395
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b455af659f94e1cdce01bbee3116d08e
https://doi.org/10.1016/s0014-2999(00)00614-2
https://doi.org/10.1016/s0014-2999(00)00614-2