Phosphatidylserine binding regulates TIM-3 effects on T cell receptor signaling

Autor: Courtney M. Smith, Mark A. Lemmon, Nithya Krishnamurthy, Alice M. Li

SUMMARYCo-signaling receptors for the T cell receptor are important therapeutic targets, with blocking co-inhibitory receptors such as PD-1 now central in immuno-oncology. Advancing additional therapeutic immune modulation approaches requires underst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3b766629f3fe550e914c05b4a3ce1f7
https://doi.org/10.1101/2021.05.07.443190

Post hospital admission blood lactate measurements are associated with mortality but not neurologic morbidity in children with cerebral malaria

Autor: Ronke Olowojesiku, Meredith G. Sherman, Amina M. Mukadam, Rami Imam, Kennedy M. Chastang, Karl B. Seydel, Alice M. Liomba, John R. Barber, Nicole F. O’Brien, Douglas G. Postels

Publikováno v: Malaria Journal, Vol 23, Iss 1, Pp 1-8 (2024)

Abstract Background In children with cerebral malaria (CM) admission blood lactate has previously guided intravenous fluid therapy and been validated as a prognostic biomarker associated with death. The usefulness of post-admission measurements of bl

Externí odkaz: https://doaj.org/article/1c13af0ae7854f378ae6cea3d2631bb5

High-copy bacterial plasmids diffuse in the nucleoid-free space, replicate stochastically and are randomly partitioned at cell division

Autor: Diane Meas, David J. Sherratt, Rodrigo Reyes-Lamothe, Marcelo E. Tolmasky, Tung Tran, Laura Lee, Alice M. Li

Publikováno v: Nucleic Acids Research

Bacterial plasmids play important roles in the metabolism, pathogenesis and bacterial evolution and are highly versatile biotechnological tools. Stable inheritance of plasmids depends on their autonomous replication and efficient partition to daughte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f41a08bb5439f995a74a49a76493b42
http://europepmc.org/articles/PMC3902917

A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin combines superb potency and lipophilicity with low toxicity

Autor: David S. Warner, Ludmil Benov, Artak Tovmasyan, Edith Butler Gralla, Ines Batinic-Haberle, Zrinka Rajić, Alice M. Li, Ivan Spasojevic, Huaxin Sheng, Miaomiao Lu

The Mn porphyrins of k(cat)(O(2)(.-)) as high as that of a superoxide dismutase enzyme and of optimized lipophilicity have already been synthesized. Their exceptional in vivo potency is at least in part due to their ability to mimic the site and loca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87da2e03b85a336d48c38faef37dff0
https://europepmc.org/articles/PMC3353805/

Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae

Autor: Jake Martins, Joan Selverstone Valentine, Edith Butler Gralla, Artak Tovmasyan, Ines Batinic-Haberle, Alice M. Li, Ivan Spasojevic

Publikováno v: Li, AM; Martins, J; Tovmasyan, A; Valentine, JS; Batinic-Haberle, I; Spasojevic, I; et al.(2014). Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae. REDOX BIOLOGY, 3, 1-6. doi: 10.1016/j.redox.2014.0.003. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5rp1h5h8
Redox Biology, Vol 3, Iss C, Pp 1-6 (2014)
Redox Biology

Cationic Mn(III) porphyrin complexes based on MnTM-2-PyP are among the most promising superoxide dismutase (SOD) mimicking compounds being considered as potential anti-inflammatory drugs. We studied four of these active compounds in the yeast Sacchar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa793b8cc317ed9c34c23e5ca57945d2