Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death

Autor: Etan R, Aber, Christopher J, Griffey, Tim, Davies, Alice M, Li, Young Joo, Yang, Katherine R, Croce, James E, Goldman, Jaime, Grutzendler, Julie C, Canman, Ai, Yamamoto

Publikováno v: Cell Reports, 2022, Vol.41(3) [Peer Reviewed Journal]

Although macroautophagy deficits are implicated across adult-onset neurodegenerative diseases, we understand little about how the discrete, highly evolved cell types of the central nervous system use macroautophagy to maintain homeostasis. One such c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f45338c227d97d4f6c0aabfc270c96
https://doi.org/10.1016/j.celrep.2022.111480

Intravital Imaging of Neocortical Heterotopia Reveals Aberrant Axonal Pathfinding and Myelination around Ectopic Neurons

Autor: Robert A. Hill, Jaime Grutzendler, Alice M. Li

Publikováno v: Cerebral Cortex.

Neocortical heterotopia consist of ectopic neuronal clusters that are frequently found in individuals with cognitive disability and epilepsy. However, their pathogenesis remains poorly understood due in part to a lack of tractable animal models. We h

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https://doi.org/10.1093/cercor/bhab090

High-copy bacterial plasmids diffuse in the nucleoid-free space, replicate stochastically and are randomly partitioned at cell division

Autor: Diane Meas, David J. Sherratt, Rodrigo Reyes-Lamothe, Marcelo E. Tolmasky, Tung Tran, Laura Lee, Alice M. Li

Publikováno v: Nucleic Acids Research

Bacterial plasmids play important roles in the metabolism, pathogenesis and bacterial evolution and are highly versatile biotechnological tools. Stable inheritance of plasmids depends on their autonomous replication and efficient partition to daughte

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http://europepmc.org/articles/PMC3902917

A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin combines superb potency and lipophilicity with low toxicity

Autor: David S. Warner, Ludmil Benov, Artak Tovmasyan, Edith Butler Gralla, Ines Batinic-Haberle, Zrinka Rajić, Alice M. Li, Ivan Spasojevic, Huaxin Sheng, Miaomiao Lu

The Mn porphyrins of k(cat)(O(2)(.-)) as high as that of a superoxide dismutase enzyme and of optimized lipophilicity have already been synthesized. Their exceptional in vivo potency is at least in part due to their ability to mimic the site and loca

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https://europepmc.org/articles/PMC3353805/

Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae

Autor: Jake Martins, Joan Selverstone Valentine, Edith Butler Gralla, Artak Tovmasyan, Ines Batinic-Haberle, Alice M. Li, Ivan Spasojevic

Publikováno v: Li, AM; Martins, J; Tovmasyan, A; Valentine, JS; Batinic-Haberle, I; Spasojevic, I; et al.(2014). Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae. REDOX BIOLOGY, 3, 1-6. doi: 10.1016/j.redox.2014.0.003. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5rp1h5h8
Redox Biology, Vol 3, Iss C, Pp 1-6 (2014)
Redox Biology

Cationic Mn(III) porphyrin complexes based on MnTM-2-PyP are among the most promising superoxide dismutase (SOD) mimicking compounds being considered as potential anti-inflammatory drugs. We studied four of these active compounds in the yeast Sacchar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa793b8cc317ed9c34c23e5ca57945d2