Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Alice Lepelley"'
Autor:
Maximilian Hirschenberger, Alice Lepelley, Ulrich Rupp, Susanne Klute, Victoria Hunszinger, Lennart Koepke, Veronika Merold, Blaise Didry-Barca, Fanny Wondany, Tim Bergner, Tatiana Moreau, Mathieu P. Rodero, Reinhild Rösler, Sebastian Wiese, Stefano Volpi, Marco Gattorno, Riccardo Papa, Sally-Ann Lynch, Marte G. Haug, Gunnar Houge, Kristen M. Wigby, Jessica Sprague, Jerica Lenberg, Clarissa Read, Paul Walther, Jens Michaelis, Frank Kirchhoff, Carina C. de Oliveira Mann, Yanick J. Crow, Konstantin M. J. Sparrer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the endoplasmic reticulum (ER)-Golgi axis to induce IFN signalling
Externí odkaz:
https://doaj.org/article/b099f69003f848078aba66c1696bcd67
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The immune response to viral infection involves the recognition of pathogen-derived nucleic acids by intracellular sensors, leading to type I interferon (IFN), and downstream IFN-stimulated gene, induction. Ineffective discrimination of self from non
Externí odkaz:
https://doaj.org/article/5325358eabfe44d9bf283545de62b8cd
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2654-2666 (2018)
Summary: ECSIT is a mitochondrial complex I (CI)-associated protein that has been shown to regulate the production of mitochondrial reactive oxygen species (mROS) following engagement of Toll-like receptors (TLRs). We have generated an Ecsit conditio
Externí odkaz:
https://doaj.org/article/ea448e806bfb4bd9b5305cc2fb220827
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148987 (2016)
Toll-like receptors (TLRs) are innate immune receptors that sense a variety of pathogen-associated molecular patterns (PAMPs) by interacting with them and subsequently initiating signal transduction cascades that elicit immune responses. TLR11 has be
Externí odkaz:
https://doaj.org/article/4bfbb5f151354d81a7c2d424e245eca8
Autor:
Xiaoming Zhang, Alice Lepelley, Elie Azria, Pierre Lebon, Gwenaelle Roguet, Olivier Schwartz, Odile Launay, Claude Leclerc, Richard Lo-Man
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52003 (2013)
Neonates are highly susceptible to infectious diseases and defective antiviral pDC immune responses have been proposed to contribute to this phenomenon. Isolated cord blood pDCs innately responded to a variety of TLR7 and TLR9 dependent viruses, incl
Externí odkaz:
https://doaj.org/article/0b6e95b8d708454ba04232b5bbb330ea
Autor:
Alice Lepelley, Stéphanie Louis, Marion Sourisseau, Helen K W Law, Julien Pothlichet, Clémentine Schilte, Laurence Chaperot, Joël Plumas, Richard E Randall, Mustapha Si-Tahar, Fabrizio Mammano, Matthew L Albert, Olivier Schwartz
Publikováno v:
PLoS Pathogens, Vol 7, Iss 2, p e1001284 (2011)
Cell-free HIV-1 virions are poor stimulators of type I interferon (IFN) production. We examined here how HIV-infected cells are recognized by plasmacytoid dendritic cells (pDCs) and by other cells. We show that infected lymphocytes are more potent in
Externí odkaz:
https://doaj.org/article/cde2846b4a194f389796090e8dd7f10e
Autor:
Marie-Louise Frémond, Marie Hully, Benjamin Fournier, Rémi Barrois, Romain Lévy, Mélodie Aubart, Martin Castelle, Delphine Chabalier, Clarisse Gins, Eugénie Sarda, Buthaina Al Adba, Sophie Couderc, Céline D’ Almeida, Claire-Marine Berat, Chloé Durrleman, Caroline Espil, Laetitia Lambert, Cécile Méni, Maximilien Périvier, Pascal Pillet, Laura Polivka, Manuel Schiff, Calina Todosi, Florence Uettwiller, Alice Lepelley, Gillian I. Rice, Luis Seabra, Sylvia Sanquer, Anne Hulin, Claire Pressiat, Lauriane Goldwirt, Vincent Bondet, Darragh Duffy, Despina Moshous, Brigitte Bader-Meunier, Christine Bodemer, Florence Robin-Renaldo, Nathalie Boddaert, Stéphane Blanche, Isabelle Desguerre, Yanick J. Crow, Bénédicte Neven
Publikováno v:
Frémond, M-L, Hully, M, Fournier, B, Barrois, R, Lévy, R, Aubart, M, Castelle, M, Chabalier, D, Gins, C, Sarda, E, Al Adba, B, Couderc, S, D'Almeida, C, Berat, C-M, Durrleman, C, Espil, C, Lambert, L, Meni, C, Perivier, M, Pillet, P, Polivka, L, Schiff, M, Todosi, C, Uettwiller, F, Lepelley, A, Rice, G I, Seabra, L, Sanquer, S, Hulin, A, Pressiat, C, Goldwirt, L, Bondet, V, Duffy, D, Moshous, D, Bader-Meunier, B, Bodemer, C, Robin-Renaldo, F, Boddaert, N, Blanche, S, Desguerre, I, Crow, Y J & Neven, B 2023, ' JAK inhibition in Aicardi-Goutières syndrome: a monocentric multidisciplinary real-world approach study ', Journal of Clinical Immunology . https://doi.org/10.1007/s10875-023-01500-z
Journal of Clinical Immunology
Journal of Clinical Immunology, 2023, ⟨10.1007/s10875-023-01500-z⟩
Journal of Clinical Immunology
Journal of Clinical Immunology, 2023, ⟨10.1007/s10875-023-01500-z⟩
The paradigm type I interferonopathy Aicardi-Goutières syndrome (AGS) is most typically characterized by severe neurological involvement. AGS is considered an immune-mediated disease, poorly responsive to conventional immunosuppression. Premised on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d11f3ba2d92b02045d598c8be04f08
https://www.pure.ed.ac.uk/ws/files/342033048/Cohort_MAIN_R1_vDEF_Unmarked.docx
https://www.pure.ed.ac.uk/ws/files/342033048/Cohort_MAIN_R1_vDEF_Unmarked.docx
Autor:
Maxime Batignes, Marine Luka, Surabhi Jagtap, Camille de Cevins, Ivan Nemazanyy, Tinhinane Fali, Víctor García-Paredes, Francesco Carbone, Brieuc P. Pérot, Bénédicte Neven, Brigitte Bader-Meunier, Pierre Quartier dit Maire, Marie Hully, Alexandre Belot, Alice Lepelley, Marie-Louise Frémond, Yanick J. Crow, Alain Fischer, Mickaël M. Ménager
SummaryAicardi-Goutières syndrome (AGS) is a genetic type I interferon (IFN)-mediated disease characterised by neurological involvement with onset in childhood. Chronic inflammation in response to uncontrolled type I IFN production is, among other t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4e75e2787bda53e074ce2ce22a41de
https://doi.org/10.2139/ssrn.4402126
https://doi.org/10.2139/ssrn.4402126
Autor:
Mathilde Labouret, Stefania Costi, Vincent Bondet, Vincent Trebossen, Enora Le Roux, Alexandra Ntorkou, Sophie Bartoli, Stéphane Auvin, Brigitte Bader-Meunier, Véronique Baudouin, Olivier Corseri, Glory Dingulu, Camille Ducrocq, Cécile Dumaine, Monique Elmaleh, Nicole Fabien, Albert Faye, Isabelle Hau, Véronique Hentgen, Théresa Kwon, Ulrich Meinzer, Naim Ouldali, Cyrielle Parmentier, Marie Pouletty, Florence Renaldo, Isabelle Savioz, Flore Rozenberg, Marie-Louise Frémond, Alice Lepelley, Gillian I. Rice, Luis Seabra, Jean-François Benoist, Darragh Duffy, Yanick J. Crow, Pierre Ellul, Isabelle Melki
Publikováno v:
Journal of Clinical Immunology
Journal of Clinical Immunology, 2022, ⟨10.1007/s10875-022-01407-1⟩
Labouret, M, Costi, S, Bondet, V, Trebossen, V, Le Roux, E, Ntorkou, A, Bartoli, S, Stephane, A, Bader-Meunier, B, Baudouin, V, Corseri, O, Dingulu, G, Hentgen, V, Kwon, T, Meinzer, U, Ouldali, N, Parmentier, C, Pouletty, M, Renaldo, F, Renaldo, F, Savioz, I, Rozenberg, F, Frémond, M-L, Lepelley, A, Rice, G I, Seabra, L, Benoist, J-F, Duffy, D, Crow, Y J, Ellul, P & Melki, I 2022, ' Juvenile neuropsychiatric systemic lupus erythematosus: identification of novel central neuroinflammation biomarkers ', Journal of Clinical Immunology . https://doi.org/10.1007/s10875-022-01407-1
Journal of Clinical Immunology, 2022, ⟨10.1007/s10875-022-01407-1⟩
Labouret, M, Costi, S, Bondet, V, Trebossen, V, Le Roux, E, Ntorkou, A, Bartoli, S, Stephane, A, Bader-Meunier, B, Baudouin, V, Corseri, O, Dingulu, G, Hentgen, V, Kwon, T, Meinzer, U, Ouldali, N, Parmentier, C, Pouletty, M, Renaldo, F, Renaldo, F, Savioz, I, Rozenberg, F, Frémond, M-L, Lepelley, A, Rice, G I, Seabra, L, Benoist, J-F, Duffy, D, Crow, Y J, Ellul, P & Melki, I 2022, ' Juvenile neuropsychiatric systemic lupus erythematosus: identification of novel central neuroinflammation biomarkers ', Journal of Clinical Immunology . https://doi.org/10.1007/s10875-022-01407-1
Introduction Juvenile systemic lupus erythematosus (j-SLE) is a rare chronic autoimmune disease affecting multiple organs. Ranging from minor features, such as headache or mild cognitive impairment, to serious and life-threatening presentations, j-ne
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, 2021, 12, pp.729763. ⟨10.3389/fimmu.2021.729763⟩
Frontiers in Immunology, Frontiers, 2021, 12, pp.729763. ⟨10.3389/fimmu.2021.729763⟩
Frontiers in Immunology, Vol 12 (2021)
Lepelley, A, Wai, T & Crow, Y J 2021, ' Mitochondrial nucleic acid as a driver of pathogenic type I interferon induction in Mendelian disease ', Frontiers in Immunology . https://doi.org/10.3389%2Ffimmu.2021.729763
Frontiers in Immunology, 2021, 12, pp.729763. ⟨10.3389/fimmu.2021.729763⟩
Frontiers in Immunology, Frontiers, 2021, 12, pp.729763. ⟨10.3389/fimmu.2021.729763⟩
Frontiers in Immunology, Vol 12 (2021)
Lepelley, A, Wai, T & Crow, Y J 2021, ' Mitochondrial nucleic acid as a driver of pathogenic type I interferon induction in Mendelian disease ', Frontiers in Immunology . https://doi.org/10.3389%2Ffimmu.2021.729763
International audience; The immune response to viral infection involves the recognition of pathogen-derived nucleic acids by intracellular sensors, leading to type I interferon (IFN), and downstream IFN-stimulated gene, induction. Ineffective discrim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9458279f215523bb96c7cb740a07385
https://hal-pasteur.archives-ouvertes.fr/pasteur-03382218/file/fimmu-12-729763.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-03382218/file/fimmu-12-729763.pdf