Region-specific blood–brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease

Autor: Gayathri Nair Sekhar, Alice L. Fleckney, Sevda Tomova Boyanova, Huzefa Rupawala, Rachel Lo, Hao Wang, Doaa B. Farag, Khondaker Miraz Rahman, Martin Broadstock, Suzanne Reeves, Sarah Ann Thomas

Publikováno v: Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-19 (2019)

Abstract Background Research into amisulpride use in Alzheimer’s disease (AD) implicates blood–brain barrier (BBB) dysfunction in antipsychotic sensitivity. Research into BBB transporters has been mainly directed towards the ABC superfamily, howe

Externí odkaz: https://doaj.org/article/e7a8b6edd6d8442e814522c660b25842

Interaction of amisulpride with GLUT1 at the blood-brain barrier. Relevance to Alzheimer’s disease

Autor: Sevda T. Boyanova, Ethlyn Lloyd-Morris, Christopher Corpe, K. Miraz Rahman, Doaa B. Farag, Lee K. Page, Hao Wang, Alice L. Fleckney, Ariana Gatt, Claire Troakes, Gema Vizcay- Barrena, Roland Fleck, Suzanne J. Reeves, Sarah A. Thomas

Blood-brain barrier (BBB) dysfunction may be involved in the increased sensitivity of Alzheimer’s disease (AD) patients to antipsychotics, including amisulpride. Studies indicate that antipsychotics interact with facilitated glucose transporters (G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd0cf121178726ba9009d5c125bea7cf
https://doi.org/10.1101/2023.05.15.540749

Region-specific blood-brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease

Autor: Khondaker M. Rahman, Doaa B. Farag, Rachel Lo, Martin Broadstock, Huzefa Rupawala, Sarah A. Thomas, Sevda Tomova Boyanova, Alice L. Fleckney, Suzanne Reeves, Gayathri N. Sekhar, Hao Wang

Publikováno v: Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-19 (2019)
Sekhar, G N, Fleckney, A L, Boyanova, S T, Rupawala, H J, Lo, R, Wang, H, Farag, D, Rahman, K M, Broadstock, M, Reeves, S & Thomas, S A 2019, ' Region-specific blood–brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease ', Fluids and Barriers of the CNS, vol. 16, no. 1, 38 . https://doi.org/10.1186/s12987-019-0158-1
Fluids and Barriers of the CNS

Background Research into amisulpride use in Alzheimer’s disease (AD) implicates blood–brain barrier (BBB) dysfunction in antipsychotic sensitivity. Research into BBB transporters has been mainly directed towards the ABC superfamily, however, solu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83da2df8c37fba523aecf82cc928c3b3
https://doi.org/10.1101/582387