Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alice L. Baumann"'
Publikováno v:
CHIMIA, Vol 72, Iss 11 (2018)
Proteins and peptides are gaining increasing interest as tools and targets in fundamental research and drug discovery. Growing research applications have prompted the need for methodologies that produce homogenous peptide and protein material. The de
Externí odkaz:
https://doaj.org/article/89ad16218bac43da9db774939c4428cd
Autor:
Alice L. Baumann, Nils Trieloff, Kristin Kemnitz-Hassanin, Christian E. Stieger, Sergej Schwagerus, Christian P. R. Hackenberger, Kevin Broi, Peter Schmieder
Publikováno v:
Journal of the American Chemical Society. 142:9544-9552
Herein we introduce vinylphosphonothiolates as a new class of cysteine-selective electrophiles for protein labeling and the formation of stable protein-protein conjugates. We developed a straightforward synthetic route to convert nucleophilic thiols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74180b8e4ef44c56880cbd2e673e81b2
https://doi.org/10.1021/jacs.0c03426
https://doi.org/10.1021/jacs.0c03426
Publikováno v:
Current opinion in chemical biology. 52
Attaching a functional moiety to a protein is required for a wealth of applications, comprising targeted delivery, controlling of enzyme activity, and prodrug-based therapy. Targeting intracellular processes requires the cellular delivery of the prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45682c7b40034c1f3191912fd9760c0c
https://pubmed.ncbi.nlm.nih.gov/31158654
https://pubmed.ncbi.nlm.nih.gov/31158654