Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alice L Herneisen"'
Publikováno v:
eLife, Vol 13 (2024)
Apicomplexan parasites balance proliferation, persistence, and spread in their metazoan hosts. AGC kinases, such as PKG, PKA, and the PDK1 ortholog SPARK, integrate environmental signals to toggle parasites between replicative and motile life stages.
Externí odkaz:
https://doaj.org/article/2182508398fe4b07b2214c97a4537246
Autor:
Alex W Chan, Malgorzata Broncel, Eden Yifrach, Nicole R Haseley, Sundeep Chakladar, Elena Andree, Alice L Herneisen, Emily Shortt, Moritz Treeck, Sebastian Lourido
Publikováno v:
eLife, Vol 12 (2023)
Apicomplexan parasites use Ca2+-regulated exocytosis to secrete essential virulence factors from specialized organelles called micronemes. Ca2+-dependent protein kinases (CDPKs) are required for microneme exocytosis; however, the molecular events tha
Externí odkaz:
https://doaj.org/article/cdceeb18a7dc4dd7aab8d093acc13d96
Publikováno v:
eLife, Vol 11 (2022)
Apicomplexan parasites cause persistent mortality and morbidity worldwide through diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca2+ signaling pathways have been repurposed in these eukaryotic pathogens to regulate parasite-specif
Externí odkaz:
https://doaj.org/article/9c5d36e593ce4f22a5f83f568d667b43
Autor:
Clare R. Harding, Saima M. Sidik, Boryana Petrova, Nina F. Gnädig, John Okombo, Alice L. Herneisen, Kurt E. Ward, Benedikt M. Markus, Elizabeth A. Boydston, David A. Fidock, Sebastian Lourido
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Artemisinin (ART) resistance poses a problem for malaria elimination. Here, the authors perform genome-wide CRISPR screens in Toxoplasma gondii and identify that the putative transporter Tmem14c and mitochondrial heme metabolism, through mitochondria
Externí odkaz:
https://doaj.org/article/b8df34776e6545b698c1d120fc0d277b
Autor:
Christopher J. Giuliano, Kenneth J. Wei, Faye M. Harling, Benjamin S. Waldman, Madeline A. Farringer, Elizabeth A. Boydston, Tammy C. T. Lan, Raina W. Thomas, Alice L. Herneisen, Allen G. Sanderlin, Isabelle Coppens, Jeffrey D. Dvorin, Sebastian Lourido
Publikováno v:
bioRxiv
SUMMARYWithin a host, pathogens encounter a diverse and changing landscape of cell types, nutrients, and immune responses. Examining host-pathogen interactions in animal models can therefore reveal aspects of infection absent from cell culture. We us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a822898638ec414ff0ec9e158c57b5
https://doi.org/10.1101/2023.03.05.531216
https://doi.org/10.1101/2023.03.05.531216
Autor:
Tyler A. Smith, Gabriella S. Lopez-Perez, Alice L. Herneisen, Emily Shortt, Sebastian Lourido
Publikováno v:
Nature Microbiology. 7:868-881
Autor:
Alex W Chan, Malgorzata Broncel, Nicole Haseley, Sundeep Chakladar, Elena Andree, Alice L Herneisen, Emily Shortt, Moritz Treeck, Sebastian Lourido
Apicomplexan parasites use Ca2+-regulated exocytosis to secrete essential virulence factors from specialized organelles called micronemes. Ca2+-dependent protein kinases (CDPKs) are required for microneme exocytosis; however, the molecular events tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b0d8e46c50890475390f1dec398b88
https://doi.org/10.1101/2023.01.11.523553
https://doi.org/10.1101/2023.01.11.523553
Apicomplexan parasites cause persistent mortality and morbidity worldwide through diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca2+ signaling pathways have been repurposed in these eukaryotic pathogens to regulate parasite-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02c622031030619e873912f094e827aa
https://doi.org/10.1101/2022.05.25.493445
https://doi.org/10.1101/2022.05.25.493445
Autor:
Alice L. Herneisen, Saima M. Sidik, David H. Drewry, Benedikt M. Markus, Sebastian Lourido, William J. Zuercher
Publikováno v:
ACS Chemical Biology. 15:1801-1807
Apicomplexan parasites include the causative agents of malaria and toxoplasmosis. Cell-based screens in Toxoplasma previously identified a chemical modulator of calcium signaling (ENH1) that blocked parasite egress from host cells and exhibited poten