SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Autor: David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inf

Externí odkaz: https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35

Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Autor: David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://doaj.org/article/7a767ab0a50943a0a5a6e85eaa10ccfe

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Autor: Christian K. Holm, Anne L. Thielke, Rasmus Ottosen, Thomas B. Poulsen, Jinrong Huang, Alice Knudsen, Lydia Bartsch, Siddharth Balachandran, Marie B. Iversen, Camilla G. Nielsen, Victoria H. Gilchrist, Trine H. Mogensen, Huy-Dung Hoang, Alon Schneider Hait, Sofie E. Jørgensen, Line S. Reinert, Suraj Peri, Jan Rehwinkel, Michael Lappe, Charlotte Möller, Michelle M. Thomsen, John Hiscott, Demi van der Horst, Esben B. Svenningsen, Anne Louise Hansen, Yonglun Luo, Jacob Thyrsted, Manja Idorn, Antonio Alcami, Ensieh Farahani, Julia Blay-Cadanet, Martin R. Jakobsen, Bruno Hernáez, Mirjam Schilling, David Olagnier, Søren R. Paludan, Angela Herengt, Tommy Alain

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Olagnier, D, Farahani, E, Thyrsted, J, Blay-Cadanet, J, Herengt, A, Idorn, M, Hait, A, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M, Reinert, L S, Lappe, M, Hoang, H-D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, no. 1, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Olagnier, D P C, Farahani, E, Jensen, J T, Blay Cadanet, J, Herengt, A A P V, Idorn, M, Schneider Hait, A I, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M M, Reinert, L S, Lappe, M, Hoang, H D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications

Versiones preprint disponibles en: http://hdl.handle.net/10261/216920 y http://hdl.handle.net/10261/217161
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c770a0f99e983608245ee2ef5c88b25
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35

mi RNA profiling identifies deregulated mi RNA s associated with osteosarcoma development and time to metastasis in two large cohorts

Autor: Alice Knudsen, Lise Lotte Hansen, Gitte Brinch Andersen, Jörg Tost, Henrik Hager

Publikováno v: Molecular Oncology
Andersen, G B, Knudsen, A, Hager, H, Hansen, L L & Tost, J 2018, ' miRNA profiling identifies deregulated miRNAs associated with osteosarcoma development and time to metastasis in two large cohorts ', Molecular Oncology, vol. 12, no. 1, pp. 114-131 . https://doi.org/10.1002/1878-0261.12154
Andersen, G B, Knudsen, A, Hager, H, Hansen, L L & Tost, J 2018, ' miRNA profiling identifies deregulated miRNAs associated with osteosarcoma development and time to metastasis in two large cohorts ', Molecular Oncology . https://doi.org/10.1002/1878-0261.12154
Molecular Oncology, Vol 12, Iss 1, Pp 114-131 (2018)

Osteosarcoma (OS) is an aggressive bone tumor primarily affecting children and adolescents. The etiology of OS is not fully understood. Thus, there is a great need to obtain a better understanding of OS development and progression. Alterations in miR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e95fbc85908aef056568f946b6338f5
https://doi.org/10.1002/1878-0261.12154

STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice

Autor: Eric Perouzel, Cedric Boularan, Søren R. Paludan, Alice Knudsen, Thierry Lioux, Morten K Skouboe, Line S. Reinert, Martin K. Thomsen

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 4, p e1006976 (2018)
Skouboe, M K, Knudsen, A, Reinert, L S, Boularan, C, Lioux, T, Perouzel, E, Thomsen, M K & Paludan, S R 2018, ' STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice ', P L o S Pathogens, vol. 14, no. 4, e1006976 . https://doi.org/10.1371/journal.ppat.1006976

In recent years, there has been an increasing interest in immunomodulatory therapy as a means to treat various conditions, including infectious diseases. For instance, Toll-like receptor (TLR) agonists have been evaluated for treatment of genital her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cebb44bbcd6c3d0f0768e7dee1b6a5
http://europepmc.org/articles/PMC5897032