Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alice J. Szuna"'
Autor:
Roger W. Blain, Alice J. Szuna
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 620:211-216
Analysis of a new antibacterial agent, Ro 23-9424 (I), in plasma has been complicated by the fact that its metabolite, fleroxacin (II), is formed not only in vivo, but also nonenzymatically by the hydrolysis of the ester bond of I. In order to minimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9795ad5537c6a531505994c4764fc56a
https://doi.org/10.1016/0378-4347(93)80006-p
https://doi.org/10.1016/0378-4347(93)80006-p
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 616:297-303
Ro 23-7637 (I) is a new drug under development for the treatment of metabolic diseases. A high-performance liquid chromatographic-ultraviolet detection (HPLC-UV) analytical procedure for its analysis in dog plasma was developed and is reported here.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e3a05dd123804ec7b77153fdb26b53
https://doi.org/10.1016/0378-4347(93)80398-n
https://doi.org/10.1016/0378-4347(93)80398-n
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 12(1)
A highly sensitive LC method has been developed and validated for quantitation of Ro 24-0238 in human plasma using Ro 24-2446 as an internal standard. With 1 ml of plasma, the limit of quantitation of the method was 50 pg ml−1 of Ro 24-0238. After
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1684ffd23c4f53bf27221f8023cfc8
https://pubmed.ncbi.nlm.nih.gov/8161596
https://pubmed.ncbi.nlm.nih.gov/8161596
Autor:
Deborah A. Sandor, Ko-Chin Khoo, J. Hannigan, Romulus K. Brazzell, Alice J. Szuna, M. M. C. Rees
Publikováno v:
Clinical Pharmacology and Therapeutics. 36:613-619
Oral cibenzoline kinetics were followed in 36 healthy subjects aged from 22 to 78 yr divided into groups of six subjects per decade between 20 and 80 yr. Each received a single, oral, 160-mg dose of cibenzoline. Blood and urine samples were collected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea66b5669e3f50dcbf888a95503b94d
https://doi.org/10.1038/clpt.1984.230
https://doi.org/10.1038/clpt.1984.230
Autor:
John C. Somberg, Paul J. Block, Alice J. Szuna, Nathan H. Carliner, Roger A. Winkle, Romulus K. Brazzell, Keiko Aogaichi, James J. Heger, Joel Morganroth, Wayne A. Colburn
Publikováno v:
Clinical pharmacokinetics. 10(2)
The pharmacokinetics of oral cibenzoline were studied in 30 arrhythmia patients as part of an ascending multiple-dose efficacy study. The elimination half-life of the drug following repetitive dosing ranged from 7.6 to 22.3 hours, with a harmonic mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692b5a337c32aeb345cf1e2cddad8c5a
https://pubmed.ncbi.nlm.nih.gov/3995859
https://pubmed.ncbi.nlm.nih.gov/3995859
Autor:
Wayne A. Colburn, Romulus K. Brazzell, Keiko Aogaichi, Alice J. Szuna, J. Morganroth, Ko-Chin Khoo
Publikováno v:
Journal of clinical pharmacology. 24(7)
The pharmacokinetics of cibenzoline were evaluated in four young healthy volunteers who received ascending oral doses of 65, 97.5, 130, 162.5, 195, 227.5, and 260 mg separated by one week. Cibenzoline plasma concentrations exhibited an apparent biexp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fbfea806a6086caf895d4cc5f69d11
https://pubmed.ncbi.nlm.nih.gov/6480874
https://pubmed.ncbi.nlm.nih.gov/6480874
Autor:
Deborah A. Sandor, Ko-Chin Khoo, Joseph W. Massarella, Joel Morganroth, Alice J. Szuna, Keiko Aogaichi
Publikováno v:
Journal of clinical pharmacology. 26(2)
Twenty-five healthy, adult male volunteers entered two open-label parallel studies, each designed to define the pharmacokinetics of single and multiple oral doses of cibenzoline. Each volunteer received a single 160-mg oral dose of cibenzoline follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d717cda18cde69fb2229c0866e4e3f39
https://pubmed.ncbi.nlm.nih.gov/3950056
https://pubmed.ncbi.nlm.nih.gov/3950056
Autor:
Karen Carter, Arthur C. Loh, Alice J. Szuna, Franz-Josef Leinweber, Morton A. Schwartz, Jerry Sepinwall
Publikováno v:
Biochemical pharmacology. 31(4)
Analgesia and brain and plasma concentrations of (−)-3-phenoxy- N -methylmorphinan (PMM) and its metabolites were determined in rats administered 50 mg/kg of 3 H-labeled PMM p.o., an approximate ED 50 . Unchanged PMM and two active metabolites, lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d65d80a6db70eb0a1fdafa4bb8535e7
https://pubmed.ncbi.nlm.nih.gov/6895995
https://pubmed.ncbi.nlm.nih.gov/6895995