Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Alice J. Adler"'
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:1967-1976
The xanthophylls—lutein, zeaxanthin, and meso-zeaxanthin (L&Z)—are found in the central region of the primate retina, which is called the macula lutea (yellow spot). How they are anchored there and what their function is has been debated for over
Autor:
Ross B. Edwards, Alice J. Adler
Publikováno v:
Experimental Eye Research. 70:227-234
It is usually assumed that IRBP (interphotoreceptor retinoid-binding protein) is the only protein present in the interphotoreceptor matrix (IPM) capable of shuttling visual-cycle retinoids between photoreceptors and the retinal pigment epithelium. Ho
Autor:
Alice J. Adler, Ross B. Edwards
Publikováno v:
Experimental Eye Research. 59:161-170
During a bleach, all-trans-retinol passes from the photoreceptor outer segments to the retinal pigment epithelium (RPE), where retinol is found associated with cellular retinol-binding protein (CRBP). Interphotoreceptor retinoid-binding protein (IRBP
Publikováno v:
Brain Research. 632:325-328
Tissues of adult rabbit brain were shown to enzymatically oxidize retinol and retinaldehyde to retinoic acid, a potent stimulator of gene expression. Rates of retinoic acid synthesis by the cerebrum, cerebellum, and meninges were comparable to, or ex
Publikováno v:
Experimental Eye Research. 54:481-490
Previous observations have shown that Müller glial cells of the vertebrate retina contain cellular retinoid-binding proteins, that the retina contains retinoic acid, and that cellular retinoic acid-binding protein is present in amacrine neurons (and
Autor:
Alice J. Adler, Romma E. Southwick
Publikováno v:
Ophthalmic Research. 24:243-252
The photoreceptor cells of the retina derive their nourishment from the choroidal blood supply behind the retina. If the extracellular interphotoreceptor matrix (IPM) mediates this retinal nutrition, then gradients in concentrations of nutrients such
Publikováno v:
Experimental Eye Research. 52:51-57
Previous work from these laboratories showed that the retention of retinyl ester synthetase activity by cultured human retinal pigment epithelium is up to tenfold greater with PM medium (Medium 199 plus insulin, other added defined components, 1% ser
Autor:
Donald V. Crabtree, Alice J. Adler
Publikováno v:
Journal of Chromatography A. 543:405-411
Analysis by supercritical fluid chromatograhy, in conjuction with chemical ionization mass spectrometry shows that methyl-5-pentafluorobenzoyl eicosatetraenoate is the stable product of the derivatization of methyl 5-hydroxyeicosatetraenoate with pen
Publikováno v:
Experimental eye research. 64(3)
Retinyl palmitate (RP) and retinyl stearate (RS) are of central importance in the visual cycle because they are the major storage molecules for retinol. In some tissues (e.g. liver) the amount of vitamin A (mostly in the form of retinyl ester) is pos
Publikováno v:
Experimental eye research. 50(5)
The presence of neural cell adhesion molecule (NCAM) was examined in the neural retina, interphotoreceptor matrix (IPM), and retinal pigment epithelium (RPE) of adult bovine and frog eyes. Using polyclonal antibodies raised against adult isoforms of