Characterization of polarization states of canine monocyte derived macrophages.

Autor: Qingkang Lyu, Edwin J A Veldhuizen, Irene S Ludwig, Victor P M G Rutten, Willem van Eden, Alice J A M Sijts, Femke Broere

Publikováno v: PLoS ONE, Vol 18, Iss 11, p e0292757 (2023)

Macrophages can reversibly polarize into multiple functional subsets depending on their micro-environment. Identification and understanding the functionality of these subsets is relevant for the study of immune‑related diseases. However, knowledge

Externí odkaz: https://doaj.org/article/55841ebcdbeb4b8caad922416e3ff8cd

CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice.

Autor: Mary J G van Helden, Dietmar M W Zaiss, Alice J A M Sijts

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52027 (2012)

Natural killer (NK) cells are innate lymphocytes that play an important role in control of viral infections. We recently showed that intranasal infection of mice with influenza virus induced the accumulation of NK cells in the airways. NK cells howev

Externí odkaz: https://doaj.org/article/c513371f9dbf4a7c9c0be958a5ce1c72

Conjugation of Cell-Penetrating Peptides to Parathyroid Hormone Affects Its Structure, Potency, and Transepithelial Permeation

Autor: Jens Berthelsen, Alice J. A. M. Sijts, Hanne Mørck Nielsen, Mie Kristensen, Henrik Franzyk, Anne Marit de Groot

Publikováno v: Bioconjugate Chemistry. 26:477-488

Delivery of therapeutic peptides and proteins by the use of cell-penetrating peptides (CPPs) as carriers has been suggested as a feasible strategy. The aim of the present study was to investigate the effect of conjugating a series of well-known CPPs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a529b9c0e046d689dc0ff06e12df90e
https://doi.org/10.1021/bc5005763

Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8+ T Cells during Bacterial Infection

Autor: Peter M. Kloetzel, Michele Mishto, Alice J. A. M. Sijts, Kathrin Textoris-Taube, Hanna H. Schalkwijk, Juliane Liepe, Anouk C.M. Platteel, Rebeca Cardoso, Petra Henklein, Christin Keller

Publikováno v: Cell Reports, Vol 20, Iss 5, Pp 1242-1253 (2017)
Platteel, A C M, Liepe, J, Textoris-Taube, K, Keller, C, Henklein, P, Schalkwijk, H H, Cardoso, R, Kloetzel, P M, Mishto, M & Sijts, A J A M 2017, ' Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8+ T Cells during Bacterial Infection ', Cell Reports, vol. 20, no. 5, pp. 1242-1253 . https://doi.org/10.1016/j.celrep.2017.07.026
Cell Reports
Cell Reports, 20(5), 1242. Elsevier Saunders

Summary: Proteasome-catalyzed peptide splicing (PCPS) generates peptides that are presented by MHC class I molecules, but because their identification is challenging, the immunological relevance of spliced peptides remains unclear. Here, we developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78882a1652debb3b238119168406beaf
https://doi.org/10.1016/j.celrep.2017.07.026

Pre-existing virus-specific CD8+ T-cells provide protection against pneumovirus-induced disease in mice

Autor: Claire J. P. Boog, Peter J.S. van Kooten, Andrew J. Easton, Alice J. A. M. Sijts, Andrea Gröne, Dietmar M. W. Zaiss, Cornelis P. J. Bekker, Mary J. van Helden, David J. Topham, Dirk H. Busch

Publikováno v: Vaccine

Highlights ► NK cells and CD8+ T-cells expand relatively late following pneumovirus infection. ► Memory CD8+ T-cells support type 1 skewing of pneumovirus-specific responses. ► Memory CD8+ T-cells prevent pneumovirus-induced immunopathology. �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311e907b99aca78801e3f29a319fdea7
https://doi.org/10.1016/j.vaccine.2012.08.027