Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Alice H. Cavanaugh"'
Autor:
Alice H. Cavanaugh, Heinric Williams, Brielle R. Schreiter, Brendon Juengst, Thomas Prince, Mitch Chernin, Chaylen Andolino, Andrew Ackerman, John Danella
Publikováno v:
Oncotarget
Muscle invasive bladder cancer (MIBC) is a common malignancy and major cause of morbidity worldwide. Over the last decade mortality rates for MIBC have not decreased as compared to other cancers indicating a need for novel strategies. The molecular c
Publikováno v:
Journal of Biological Chemistry. 285:19854-19864
Metabolic labeling with [(35)S]cysteine was used to characterize early events in CaSR biosynthesis. [(35)S]CaSR is relatively stable (half-life approximately 8 h), but maturation to the final glycosylated form is slow and incomplete. Incorporation of
Publikováno v:
Oncotarget
Heat shock protein 90 (HSP90) plays a critical role in the survival of cancer cells including muscle invasive bladder cancer (MIBC). The addiction of tumor cells to HSP90 has promoted the development of numerous HSP90 inhibitors and their use in clin
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136702 (2015)
PLoS ONE
PLoS ONE
Calcium sensing receptors (CaSR) interact with 14-3-3 binding proteins at a carboxyl terminal arginine-rich motif. Mutations identified in patients with familial hypocalciuric hypercalcemia, autosomal dominant hypocalcemia, pancreatitis or idiopathic
Autor:
Alice H. Cavanaugh, Anna Jenkins, Yves Brandenburger, Gretchen Poortinga, Lawrence I. Rothblum, Tom Moss, Katherine M. Hannan, Grant A. McArthur, Ross D. Hannan, Richard B. Pearson, Kerith Sharkey
Publikováno v:
Molecular and Cellular Biology. 23:8862-8877
Mammalian target of rapamycin (mTOR) is a key regulator of cell growth acting via two independent targets, ribosomal protein S6 kinase 1 (S6K1) and 4EBP1. While each is known to regulate translational efficiency, the mechanism by which they control c
Autor:
Tom Smink, Lawrence I. Rothblum, Mingyue Lun, Alice H. Cavanaugh, Iwona Hirschler-Laszkiewicz, Qiyue Hu, Ayoub Mirza
Publikováno v:
Journal of Biological Chemistry. 278:18953-18959
The human homologue of yeast Rrn3, a 72-kDa protein, is essential for ribosomal DNA (rDNA) transcription. Although the importance of Rrn3 function in rDNA transcription is well established, its mechanism of action has not been determined. It has been
Publikováno v:
Gene. 556(1)
Mammalian PAF49 and PAF53 form a heterodimer and are essential for transcription. However their roles in transcription have not been specifically defined. While the yeast homologues are “not essential” proteins, yeast cells deficient in the homol
Publikováno v:
Journal of Urology. 191
Autor:
Alice H. Cavanaugh, Marc Poirot, S. Stoney Simons, Sergei Y. Plisov, Dean P. Edwards, Kevin J. Modarress
Publikováno v:
Journal of Steroid Biochemistry and Molecular Biology
Journal of Steroid Biochemistry and Molecular Biology, Elsevier, 1998, 67, pp.251-66
Journal of Steroid Biochemistry and Molecular Biology, Elsevier, 1998, 67, pp.251-66
We previously reported evidence for two subpopulations of several classes of steroid receptors that could be distinguished by their requirement of a low molecular weight factor (Mr=700-3000 Da) for binding to nonspecific, calf thymus DNA-cellulose [C
Autor:
Ross D. Hannan, William M. Hempel, Alice H. Cavanaugh, Toru Arino, Stefan I. Dimitrov, Lawrence I. Rothblum, Tom Moss
Publikováno v:
Journal of Biological Chemistry. 273:1257-1267
Overlapping cDNA clones encoding the two largest subunits of rat RNA polymerase I, designated A194 and A127, were isolated from a Reuber hepatoma cDNA library. Analyses of the deduced amino acid sequences revealed that A194 and A127 are the homologue