Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Alice H. Berger"'
Autor:
Siobhan O’Brien, Alice H. Berger
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 10, Pp 100618- (2023)
Publishing in Science, Girish and colleagues achieve chromosome-level genome editing to reveal a requirement for aneuploidy in breast and melanoma cancers. Authors developed and leveraged ReDACT (restoring disomy in aneuploid cells using CRISPR targe
Externí odkaz:
https://doaj.org/article/a5297b29c490486a9eea025f7902fe81
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Alternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently caused by somatic splice site mutations or somatic mutations of splicing factor genes. However
Externí odkaz:
https://doaj.org/article/37b055328bd444adb4bdac801f188e35
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sen
Externí odkaz:
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
Autor:
Amanda K. Riley, Alice H. Berger
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
In recent work, we performed CRISPR/Cas9 screening in RIT1 (Ras-like in all tissues)-mutant cancer cells. We found that RIT1-mutant cells are vulnerable to loss of mitotic regulators, and mutant RIT1 synergizes with YAP1 (yes-associated protein 1) in
Externí odkaz:
https://doaj.org/article/3488c6b845a04380a4140fe073232125
Autor:
Hannah Gelman, Jennifer N. Dines, Jonathan Berg, Alice H. Berger, Sarah Brnich, Fuki M. Hisama, Richard G. James, Alan F. Rubin, Jay Shendure, Brian Shirts, Douglas M. Fowler, Lea M. Starita, On behalf of the Brotman Baty Institute Mutational Scanning Working Group
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-11 (2019)
Abstract Variants of uncertain significance represent a massive challenge to medical genetics. Multiplexed functional assays, in which the functional effects of thousands of genomic variants are assessed simultaneously, are increasingly generating da
Externí odkaz:
https://doaj.org/article/3bfc5e57d58d4ef1bdcda6d327fe1aa3
Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway
Autor:
Jian Carrot-Zhang, Xiaotong Yao, Siddhartha Devarakonda, Aditya Deshpande, Jeffrey S. Damrauer, Tiago Chedraoui Silva, Christopher K. Wong, Hyo Young Choi, Ina Felau, A. Gordon Robertson, Mauro A.A. Castro, Lisui Bao, Esther Rheinbay, Eric Minwei Liu, Tuan Trieu, David Haan, Christina Yau, Toshinori Hinoue, Yuexin Liu, Ofer Shapira, Kiran Kumar, Karen L. Mungall, Hailei Zhang, Jake June-Koo Lee, Ashton Berger, Galen F. Gao, Binyamin Zhitomirsky, Wen-Wei Liang, Meng Zhou, Sitapriya Moorthi, Alice H. Berger, Eric A. Collisson, Michael C. Zody, Li Ding, Andrew D. Cherniack, Gad Getz, Olivier Elemento, Christopher C. Benz, Josh Stuart, J.C. Zenklusen, Rameen Beroukhim, Jason C. Chang, Joshua D. Campbell, D. Neil Hayes, Lixing Yang, Peter W. Laird, John N. Weinstein, David J. Kwiatkowski, Ming S. Tsao, William D. Travis, Ekta Khurana, Benjamin P. Berman, Katherine A. Hoadley, Nicolas Robine, Matthew Meyerson, Ramaswamy Govindan, Marcin Imielinski
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108784- (2021)
Externí odkaz:
https://doaj.org/article/4264da604a8b4596a7e8b99d914ad26d
Autor:
Haritha Mathsyaraja, Jonathen Catchpole, Brian Freie, Emily Eastwood, Ekaterina Babaeva, Michael Geuenich, Pei Feng Cheng, Jessica Ayers, Ming Yu, Nan Wu, Sitapriya Moorthi, Kumud R Poudel, Amanda Koehne, William Grady, A McGarry Houghton, Alice H Berger, Yuzuru Shiio, David MacPherson, Robert N Eisenman
Publikováno v:
eLife, Vol 10 (2021)
MGA, a transcription factor and member of the MYC network, is mutated or deleted in a broad spectrum of malignancies. As a critical test of a tumor suppressive role, we inactivated Mga in two mouse models of non-small cell lung cancer using a CRISPR-
Externí odkaz:
https://doaj.org/article/e444f5d17b9d4890b2bf40c9a7a0bd54
Autor:
Pier Paolo Pandolfi, Sabina Signoretti, Carlos Cordon-Cardo, Mireia Castillo-Martin, Rodolfo Montironi, Laura Poliseno, Caterina Nardella, Alice H. Berger, Christopher Ng, Valentina Quarantotti, Robin M. Hobbs, Brett S. Carver, Tomoki Ishikawa, Nina Seitzer, Ugo Ala, Jlenia Guarnerio, Riccardo Taulli, Ming Chen, Shohreh Varmeh, Andrea Lunardi
Supplementary Figure S3. ERG binding to CHK1 promoter.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b1315a816fc729cdef3101dd0afe68
https://doi.org/10.1158/2159-8290.22530336.v1
https://doi.org/10.1158/2159-8290.22530336.v1
Autor:
Pier Paolo Pandolfi, Sabina Signoretti, Carlos Cordon-Cardo, Mireia Castillo-Martin, Rodolfo Montironi, Laura Poliseno, Caterina Nardella, Alice H. Berger, Christopher Ng, Valentina Quarantotti, Robin M. Hobbs, Brett S. Carver, Tomoki Ishikawa, Nina Seitzer, Ugo Ala, Jlenia Guarnerio, Riccardo Taulli, Ming Chen, Shohreh Varmeh, Andrea Lunardi
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12dce6af5c612abe978f41898f85e1d2
https://doi.org/10.1158/2159-8290.22530345.v1
https://doi.org/10.1158/2159-8290.22530345.v1
Autor:
Eric A. Collisson, Matthew Meyerson, Angela Brooks, Byron Hann, Youngho Seo, Kuang-Yu Jen, Sergio Wong, Alice H. Berger, Peter Choi, Wei Wu, John Greer, Nir Peled, Xinyuan Lu
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d79f3379b9df801161909c501e6ee93
https://doi.org/10.1158/0008-5472.22415409
https://doi.org/10.1158/0008-5472.22415409