Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Alice Giustacchini"'
Autor:
Tiago C. Luis, Nikolaos Barkas, Joana Carrelha, Alice Giustacchini, Stefania Mazzi, Ruggiero Norfo, Bishan Wu, Affaf Aliouat, Jose A. Guerrero, Alba Rodriguez-Meira, Tiphaine Bouriez-Jones, Iain C. Macaulay, Maria Jasztal, Guangheng Zhu, Heyu Ni, Matthew J. Robson, Randy D. Blakely, Adam J. Mead, Claus Nerlov, Cedric Ghevaert, Sten Eirik W. Jacobsen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Hematopoietic stem cells (HSCs) residing in specialized niches in the bone marrow are responsible for the balanced output of multiple short-lived blood cell lineages in steady-state and in response to different challenges. However, feedback
Externí odkaz:
https://doaj.org/article/45c592524cf44d3ebb3a8722a44142e6
Autor:
Ilaria M. Michelozzi, Jahangir Sufi, Thomas A. Adejumo, Persis J. Amrolia, Christopher J. Tape, Alice Giustacchini
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101174- (2022)
Summary: Here, we present a comprehensive protocol for the generation and functional characterization of chimeric antigen receptor (CAR) T cells and their products by mass cytometry in a reproducible and scalable manner. We describe the production of
Externí odkaz:
https://doaj.org/article/01cf7f21fdd3460fb2113d0a586616ae
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Acute Myeloid Leukaemia (AML) is a phenotypically and genetically heterogenous blood cancer characterised by very poor prognosis, with disease relapse being the primary cause of treatment failure. AML heterogeneity arise from different genetic and no
Externí odkaz:
https://doaj.org/article/99f4e8c47ed04a738691e1948cb88a41
Publikováno v:
Cancers, Vol 13, Iss 11, p 2816 (2021)
Current treatment outcome for acute myeloid leukemia (AML) patients is unsatisfactory and characterized by high rates of relapse and poor overall survival. Increasing evidence points to a crucial role of leukemic stem cells (LSC) and the bone marrow
Externí odkaz:
https://doaj.org/article/60a1b86b5af0442f855e2cab4076fb1d
Autor:
Amit Grover, Alejandra Sanjuan-Pla, Supat Thongjuea, Joana Carrelha, Alice Giustacchini, Adriana Gambardella, Iain Macaulay, Elena Mancini, Tiago C. Luis, Adam Mead, Sten Eirik W. Jacobsen, Claus Nerlov
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in o
Externí odkaz:
https://doaj.org/article/81c978c8b4c243cab74583942727f9f7
Autor:
Ilaria M. Michelozzi, Eduardo Gomez-Castaneda, Ruben V. C. Pohle, Ferran Cardoso Rodriguez, Jahangir Sufi, Pau Puigdevall Costa, Meera Subramaniyam, Efstratios Kirtsios, Ayad Eddaoudi, Si Wei Wu, Aleks Guvenel, Jonathan Fisher, Sara Ghorashian, Martin A. Pule, Christopher J. Tape, Sergi Castellano, Persis J. Amrolia, Alice Giustacchini
Publikováno v:
Blood advances.
We recently described a low-affinity second-generation CD19 chimeric antigen receptor (CAR) CAT that showed enhanced expansion, cytotoxicity, and antitumor efficacy compared with the high-affinity (FMC63-based) CAR used in tisagenlecleucel, in precli
Publikováno v:
Cancers, Vol 13, Iss 2816, p 2816 (2021)
Cancers
Cancers
Simple Summary Chimeric antigen receptor (CAR) T-cells are powerful therapeutic tools that have revolutionized the treatment of several hematological malignancies. However, their therapeutic application in acute myeloid leukemia (AML) remains challen
Autor:
Ilaria M. Michelozzi, Eduardo Gomez Castaneda, Ruben V.C. Pohle, Ferran Cardoso Rodriguez, Jahangir Sufi, Pau Puigdevall Costa, Meera Subramaniyam, Efstratios Kirtsios, Ayad Eddaoudi, Si Wei Wu, Aleks Guvenel, Jonathan Fisher, Sara Ghorashian, Martin A. Pule, Christopher J. Tape, Sergi Castellano, Persis J. Amrolia, Alice Giustacchini
We recently described a low-affinity second-generation CD19 chimeric antigen receptor (CAR) CAT that showed enhanced expansion, cytotoxicity, and anti-tumour efficacy compared to the high-affinity (FMC63 based) CAR used in Tisagenlecleucel, in pre-cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b79f0bbfa6bbb39f2b825d5e9d2ba484
https://doi.org/10.1101/2020.09.22.291831
https://doi.org/10.1101/2020.09.22.291831
Autor:
Delfim Duarte, Maria J. Rodriguez Colman, Shruti Naik, Mariaceleste Aragona, Elphège P. Nora, Alice Giustacchini
Publikováno v:
Cell Stem Cell
COVID-19 has unfortunately halted lab work, conferences, and in-person networking, which is especially detrimental to researchers just starting their labs. Through social media and our reviewer networks, we met some early-career stem cell investigato
Autor:
Ruben V.C. Pohle, Meera Subramaniyam, Sara Ghorashian, Jahangir Sufi, Martin Pule, Sergi Castellano, Ilaria M. Michelozzi, Persis Amrolia, Pau Puigdevall, Eduardo Gomez-Castaneda, Christopher J. Tape, Alice Giustacchini, Aleks Guvenel, Si Wei Wu, Ferran Cardoso Rodriguez
Publikováno v:
Blood. 136:52-53
We have recently described a low-affinity second-generation anti-CD19 Chimeric Antigen Receptor (CAR) (CAT), characterized by faster antigen dissociation rate which showed enhanced expansion, cytotoxicity and anti-tumour efficacy compared with the hi