Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alice Ghidini"'
Autor:
François Halloy, Annabelle Biscans, Katherine E. Bujold, Alexandre Debacker, Alyssa C. Hill, Aurélie Lacroix, Olivia Luige, Roger Strömberg, Linda Sundstrom, Jörg Vogel, Alice Ghidini
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 313-332 (2022)
RNA-based therapeutics are emerging as a powerful platform for the treatment of multiple diseases. Currently, the two main categories of nucleic acid therapeutics, antisense oligonucleotides and small interfering RNAs (siRNAs), achieve their therapeu
Externí odkaz:
https://doaj.org/article/cd8fb0a6285b407a8a63465d0c07a69f
Autor:
Evangelia Lekka, Aleksandra Kokanovic, Simone Mosole, Gianluca Civenni, Sandro Schmidli, Artur Laski, Alice Ghidini, Pavithra Iyer, Christian Berk, Alok Behera, Carlo V. Catapano, Jonathan Hall
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The Lin28/let-7 axis regulates metabolic pathways in normal and pathological contexts. Here the authors show that pharmacological inhibition of Lin28 protects against lipid accumulation in multiple preclinical models of nonalcoholic fatty liver disea
Externí odkaz:
https://doaj.org/article/4eb77299f3fe4991b4cc526dc0ff726c
Autor:
Friederike Danneberg, Alice Ghidini, Plamena Dogandzhiyski, Elisabeth Kalden, Roger Strömberg, Michael W. Göbel
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 493-498 (2015)
Tris(2-aminobenzimidazole) conjugates with antisense oligonucleotides are effective site-specific RNA cleavers. Their mechanism of action is independent of metal ions. Here we investigate conjugates with peptide nucleic acids (PNA). RNA degradation o
Externí odkaz:
https://doaj.org/article/648a2b47cf334c29ad8f95501f7e9834
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1495-1503 (2014)
Pyrene derivatives can be incorporated into nucleic acid analogs in order to obtain switchable probes or supramolecular architectures. In this paper, peptide nucleic acids (PNAs) containing 1 to 3 1-pyreneacetic acid units (PNA1–6) with a sequence
Externí odkaz:
https://doaj.org/article/ba4fe6ae593943418d88b6b064c9f556
Publikováno v:
Molecules, Vol 19, Iss 3, Pp 3135-3148 (2014)
Several different approaches have been explored for conjugation of oligoethers to PNA with internally or N-terminal placed diaminopropionic acid residues. Single and double conjugation of 2-(2-(2-aminoethoxy)ethoxy)ethanol was obtained using carbonyl
Externí odkaz:
https://doaj.org/article/5f4a52430a7141368cf953f9655115b9
Publikováno v:
Molecules, Vol 24, Iss 4, p 672 (2019)
Peptide nucleic acid (PNA)-neocuproine conjugates have been shown to efficiently catalyse the cleavage of RNA target sequences in the presence of Cu2+ ions in a site-specific manner. These artificial enzymes are designed to force the formation of a b
Externí odkaz:
https://doaj.org/article/5e4f03eefed544b6bbabe6de9ac1487a
Publikováno v:
Molecules, Vol 22, Iss 11, p 1856 (2017)
In this report, we investigate the efficiency and selectivity of a Zn2+-dependent peptide nucleic acid-based artificial ribonuclease (PNAzyme) that cleaves RNA target sequences. The target RNAs are varied to form different sizes (3 and 4 nucleotides,
Externí odkaz:
https://doaj.org/article/a8f568cf96474db38ac580fbbf4ce536
Autor:
Jonathan Hall, Daniel Schümperli, Alexandre Theocharides, Anna Elisabeth Minder, Nicole Wildner-Verhey van Wijk, Veronika Lysenko, Jessica Jucker, Elisabeth I. Minder, Xiaoye Schneider-Yin, Jasmin Barman-Aksözen, François Halloy, Alice Ghidini, Chia Pei Grubenmann, Marc-David Ruepp, Pavithra S. Iyer
Publikováno v:
Cell chemical biology. 28(8)
Erythropoietic protoporphyria (EPP) is a rare disease in which patients experience severe light sensitivity. It is caused by a deficiency of ferrochelatase (FECH), the last enzyme in heme biosynthesis (HBS). The lack of FECH causes accumulation of it
Autor:
Alexandre Theocharides, Alice Ghidini, Paulina Ćwiek, Nicole Wildner-Verhey van Wijk, Jonathan Hall, Elisabeth I. Minder, Jasmin Barman-Aksözen, François Halloy, Pavithra S. Iyer, Xiaoye Schneider-Yin, Daniel Schümperli
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 48 (9)
Nucleic Acids Research, 48 (9)
Erythropoietic protoporphyria (EPP) is a rare genetic disease in which patients experience acute phototoxic reactions after sunlight exposure. It is caused by a deficiency in ferrochelatase (FECH) in the heme biosynthesis pathway. Most patients exhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d611b75c366a2bbd66ec0a4ddeaee46
Publikováno v:
Organic & Biomolecular Chemistry. 14:2768-2773
We have previously shown that PNA-neocuproine conjugates can act as artificial RNA restriction enzymes. In the present study we have additionally conjugated the PNA with different entities, such as oligoethers, peptides etc. and also constructed syst