Výsledky vyhledávání - "Alice Fletcher"

Akademický článek

A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation

Autor: Alice Fletcher, Dean Clift, Emma de Vries, Sergio Martinez Cuesta, Timothy Malcolm, Francesco Meghini, Raghothama Chaerkady, Junmin Wang, Abby Chiang, Shao Huan Samuel Weng, Jonathan Tart, Edmond Wong, Gerard Donohoe, Philip Rawlins, Euan Gordon, Jonathan D. Taylor, Leo James, James Hunt

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein, which functions as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor patient prognosis, implicating it as an attractive therapeutic targ

Externí odkaz: https://doaj.org/article/0a4a30a2a8bb41ef8d8998148778ebbb

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Akademický článek

Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity

Autor: Martin Potts, Alice Fletcher-Etherington, Katie Nightingale, Federica Mescia, Laura Bergamaschi, Fernando J. Calero-Nieto, Robin Antrobus, James Williamson, Harriet Parsons, Edward L. Huttlin, Nathalie Kingston, Berthold Göttgens, John R. Bradley, Paul J. Lehner, Nicholas J. Matheson, Kenneth G.C. Smith, Mark R. Wills, Paul A. Lyons, Michael P. Weekes

Publikováno v: Cell Reports, Vol 42, Iss 6, Pp 112613- (2023)

Summary: Certain serum proteins, including C-reactive protein (CRP) and D-dimer, have prognostic value in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nonetheless, these factors are non-specific, providing limited mecha

Externí odkaz: https://doaj.org/article/c7326025d3cb4f20b0a4a053867e6734

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Akademický článek

Identification of an interactome network between lncRNAs and miRNAs in thyroid cancer reveals SPTY2D1-AS1 as a new tumor suppressor

Autor: Julia Ramírez-Moya, León Wert-Lamas, Adrián Acuña-Ruíz, Alice Fletcher, Carlos Wert-Carvajal, Christopher J. McCabe, Pilar Santisteban, Garcilaso Riesco-Eizaguirre

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Thyroid cancer is the most common primary endocrine malignancy in adults and its incidence is rapidly increasing. Long non-coding RNAs (lncRNAs), generally defined as RNA molecules longer than 200 nucleotides with no protein-encoding capacit

Externí odkaz: https://doaj.org/article/c28b93dd23654d67a6e525026b10e771

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Akademický článek

Selective modulation of cell surface proteins during vaccinia infection: A resource for identifying viral immune evasion strategies.

Autor: Delphine M Depierreux, Arwen F Altenburg, Lior Soday, Alice Fletcher-Etherington, Robin Antrobus, Brian J Ferguson, Michael P Weekes, Geoffrey L Smith

Publikováno v: PLoS Pathogens, Vol 18, Iss 6, p e1010612 (2022)

The interaction between immune cells and virus-infected targets involves multiple plasma membrane (PM) proteins. A systematic study of PM protein modulation by vaccinia virus (VACV), the paradigm of host regulation, has the potential to reveal not on

Externí odkaz: https://doaj.org/article/259faa9585bf468b837ff3968ef6c20d

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