Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Alice E. Zemljic-Harpf"'
Statin Use in Relation to COVID-19 and Other Respiratory Infections: Muscle and Other Considerations
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 14, p 4659 (2023)
Statins have been widely advocated for use in COVID-19 based on large favorable observational associations buttressed by theoretical expected benefits. However, past favorable associations of statins to pre-COVID-19 infection outcomes (also buttresse
Externí odkaz:
https://doaj.org/article/001920195d2645f2a117274112404c6d
Autor:
Nina C. Weber, Jan M. Schilling, Moritz V. Warmbrunn, Mehul Dhanani, Raphaela Kerindongo, Jamila Siamwala, Young Song, Alice E. Zemljic-Harpf, McKenzie J. Fannon, Markus W. Hollmann, Benedikt Preckel, David M. Roth, Hemal H. Patel
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2640 (2019)
The noble gas helium (He) induces cardioprotection in vivo through unknown molecular mechanisms. He can interact with and modify cellular membranes. Caveolae are cholesterol and sphingolipid-enriched invaginations of the plasma-membrane-containing ca
Externí odkaz:
https://doaj.org/article/97fd7c8db8cc480fb17044fe98ab8bcb
Autor:
Leonardo Nogueira, Alice E. Zemljic-Harpf, Raihana Yusufi, Maryam Ranjbar, Christopher Susanto, Kechun Tang, Sushil K. Mahata, Patricia A. Jennings, Ellen C. Breen
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 323(6)
To date, there has been a lag between the rise in E-cigarette use and an understanding of the long-term health effects. Inhalation of E-cigarette aerosol delivers high doses of nicotine, raises systemic cytokine levels, and compromises cardiopulmonar
Publikováno v:
Clinical Science. 135:1311-1332
Anthracyclines are effective chemotherapeutic agents, commonly used in the treatment of a variety of hematologic malignancies and solid tumors. However, their use is associated with a significant risk of cardiovascular toxicities and may result in ca
Autor:
Sifat M. Alam, Kyle J. Gierden, Tengteng Zhao, Sun S. Lu, Mihir Dixit, Aleksandra Babicheva, Jason Yuan, Volker Vallon, Alice E. Zemljic‐Harpf
Publikováno v:
The FASEB Journal. 36
Autor:
Mehul Dhanani, So Yeon Kim, Kang Ho Kim, Brian P. Head, Jan M. Schilling, David M. Roth, Joseph Leem, Hemal H. Patel, Alice E. Zemljic-Harpf
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Cirrhotic cardiomyopathy is a clinical syndrome in patients with liver cirrhosis characterized by blunted cardiac contractile responses to stress and/or heart rate-corrected QT (QTc) interval prolongation. Caveolin-3 (Cav-3) plays a critical role in
Autor:
Yousin Suh, Rudi Micheletti, Tobias Wagner, Alice E. Zemljic-Harpf, Havilah Taylor, Michael G. Rosenfeld
Publikováno v:
Circulation Research. 129
Regulation of the geroprotective histone-deacetylase SIRT1 is an important physiological strategy to protect against cardiovascular disease. SIRT1 activity regulates the oxidative stress response, DNA damage pathways, cell death, and cardioprotective
Autor:
Jesse Wackerbarth, Martin Marsala, Oleksandr Platoshyn, David M. Roth, Atsushi Sawada, Piyush M. Patel, Joseph Leem, Hemal H. Patel, Junji Egawa, Brian P. Head, Alice E. Zemljic-Harpf, Shanshan Wang, Minyu Jian, Jan M. Schilling
Publikováno v:
The FASEB Journal. 33:7545-7554
Interventions that preserve motor neurons or restore functional motor neuroplasticity may extend longevity in amyotrophic lateral sclerosis (ALS). Delivery of neurotrophins may potentially revive degenerating motor neurons, yet this approach is depen
Autor:
Hemal H. Patel, Sili Fan, H. Kirk Hammond, Dinesh Kumar Barupal, M. Dan McKirnan, Alice E. Zemljic-Harpf, David M. Roth, Yasuhiro Ichikawa, Zheng Zhang
Publikováno v:
Life Sciences. 221:212-223
Aims To determine the metabolic adaptations to compensated heart failure using a reproducible model of myocardial infarction and an unbiased metabolic screen. To address the limitations in sample availability and model variability observed in preclin
Autor:
Anna Schwarz, Jan M. Schilling, Ingrid R. Niesman, Georgios Kararigas, Anna R. Busija, Nancy D. Dalton, Joseph C. Godoy, John C. Drummond, Alice E. Zemljic-Harpf, Erika A. Alvarez, Hemal H. Patel, David M. Roth, Adam Kassan
Publikováno v:
The FASEB Journal. 33:1209-1225
Statins, which reduce LDL-cholesterol by inhibition of 3-hydroxy-3-methylglutaryl–coenzyme A reductase, are among the most widely prescribed drugs. Skeletal myopathy is a known statin-induced adverse effect associated with mitochondrial changes. We