Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Alice E. Wiedeman"'
Autor:
Sarah Alice Long, Virginia S. Muir, Britta E. Jones, Valerie Z. Wall, Alyssa Ylescupidez, Anne M. Hocking, Stephan Pribitzer, Jerill Thorpe, Bryce Fuchs, Alice E. Wiedeman, Megan Tatum, Katharina Lambert, Hannes Uchtenhagen, Cate Speake, Bernard Ng, Alexander T. Heubeck, Troy R. Torgerson, Adam K. Savage, Michael A. Maldonado, Neelanjana Ray, Vadim Khaychuk, Jinqi Liu, Peter S. Linsley, Jane H. Buckner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Exhausted CD8 T cells (TEX) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT+KLRG1+ TEX with teplizumab therapy in type 1 diabetes (T1D), in the absence of treatment we f
Externí odkaz:
https://doaj.org/article/848afa4859044e9fb280078686f378e7
Autor:
Hamid Bolouri, Rhonda E. Ries, Alice E. Wiedeman, Tiffany Hylkema, Sheila Scheiding, Vivian H. Gersuk, Kimberly O’Brien, Quynh-Anh Nguyen, Jenny L. Smith, S. Alice Long, Soheil Meshinchi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
IL6 expression in the bone marrow is associated with reduced survival in paediatric AML. Here, the authors used RNA-seq to identify treatment resistance-associated co-occurring inflammatory signalling in leukemic cells.
Externí odkaz:
https://doaj.org/article/135f6f6b486a456e8346955a1b0198e3
Autor:
Megan E. Smithmyer, Alice E. Wiedeman, David A. G. Skibinski, Adam K. Savage, Carolina Acosta‐Vega, Sheila Scheiding, Vivian H. Gersuk, Colin O'Rourke, S. Alice Long, Jane H. Buckner, Cate Speake
Publikováno v:
Cytometry Part A. 101:351-360
Mislabeling samples or data with the wrong participant information can affect study integrity and lead investigators to draw inaccurate conclusions. Quality control to prevent these types of errors is commonly embedded into the analysis of genomic da
Publikováno v:
Immunology and Cell Biology
Immune monitoring enables a better understanding of disease processes and response to therapy, but has been challenging in the setting of chronic autoimmunity because of unknown etiology, variable and protracted kinetics of the disease process, heter
Autor:
Katharina Lambert, Keagan G. Moo, Azlann Arnett, Gautam Goel, Alex Hu, Kaitlin J. Flynn, Cate Speake, Alice E. Wiedeman, Vivian H. Gersuk, Peter S. Linsley, Carla J. Greenbaum, S. Alice Long, Rebecca Partridge, Jane H. Buckner, Bernard Khor
Publikováno v:
Sci Transl Med
Individuals with Down syndrome show cellular and clinical features of dysregulated aging of the immune system, including a shift from naïve to memory T cells and increased incidence of autoimmunity. However, a quantitative understanding of how vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e77669817b9a186f6f588776631627
https://europepmc.org/articles/PMC9312285/
https://europepmc.org/articles/PMC9312285/
Autor:
Gabriele Blahnik, Elisavet Serti, Matthew J. Dufort, Cate Speake, Peter S. Linsley, Hannah A. DeBerg, Anna Kus, Eddie A. James, Bertrand Haas, Scott R. Presnell, Virginia S. Muir, Gerald T. Nepom, Mario G. Rosasco, S. Alice Long, Alice E. Wiedeman, Carla J. Greenbaum
Publikováno v:
Journal of Clinical Investigation. 130:480-490
Although most patients with type 1 diabetes (T1D) retain some functional insulin-producing islet β cells at the time of diagnosis, the rate of further β cell loss varies across individuals. It is not clear what drives this differential progression
Autor:
Adam K. Savage, Carolina Acosta-Vega, Vivian H. Gersuk, Cate Speake, S. Alice Long, Megan E Smithmyer, Sheila Scheiding, David A. G. Skibinski, Jane H. Buckner, Alice E. Wiedeman
Mislabeling samples or data with the wrong participant information can impact study integrity and lead investigators to draw inaccurate conclusions. Quality control to prevent these types of errors is commonly embedded into the analysis of genomic da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e12dd2179b2e1f9cd8afb4daf0ef8981
https://doi.org/10.1101/2021.10.26.465993
https://doi.org/10.1101/2021.10.26.465993
Autor:
Bernard Khor, Rebecca Partridge, S. Alice Long, Katharina Lambert, Azlann Arnett, Carla J. Greenbaum, Keagan G. Moo, Kaitlin J. Flynn, Cate Speake, Gautam Goel, Jane H. Buckner, Alice E. Wiedeman
People with Down syndrome show cellular and clinical features of dysregulated aging of the immune system, including naïve-memory shift in the T cell compartment and increased incidence of autoimmunity. However, a quantitative understanding of how va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::365e0d9f839586202e1a059c8f5cb231
https://doi.org/10.1101/2021.09.13.460115
https://doi.org/10.1101/2021.09.13.460115
Autor:
Sharon K. Sahi, Elizabeth A. Barnes, J. Lawson, Susan L. Fink, Sudhakar Pipavath, G. Cromer, Mark M. Wurfel, Eric D. Morrell, Xin-Ya Chai, S. Sakr, N. Koetje, D. Lum, T. Liu, Pavan K. Bhatraju, A. Sader, Laura Evans, M. Orlov, Neha A. Sathe, A. Long, C. Brager, C. Acosta Vega, A. Garay, T.E. West, Alice E. Wiedeman, Carmen Mikacenic, M. Bray
Publikováno v:
TP3. TP003 COVID-19 INFECTIONS, MECHANISMS, AND CLINICAL IMPLICATIONS.
RATIONALE: Several studies have identified host immune signatures that are associated with COVID-19. However, it is unclear whether these immune signatures are specific to COVID-19 or are merely reflective of illness severity. In vitro studies have d
Publikováno v:
The Journal of Immunology. 208:108.23-108.23
Islet-specific CD8 T cell exhaustion (TEX) is linked to slower progression of type 1 diabetes (T1D). However, in the therapeutic setting, only global TEX has been studied. Here we address whether TEX among autoreactive cells in clinical trials relate