Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Alice E. Jasper"'
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Akademický článek
Dysregulated Neutrophil Phenotype and Function in Hospitalised Non-ICU COVID-19 Pneumonia
Autor: Kylie B. R. Belchamber, Onn S. Thein, Jon Hazeldine, Frances S. Grudzinska, Aduragbemi A. Faniyi, Michael J. Hughes, Alice E. Jasper, Kay Por Yip, Louise E. Crowley, Sebastian T. Lugg, Elizabeth Sapey, Dhruv Parekh, David R. Thickett, Aaron Scott
Publikováno v: Cells, Vol 11, Iss 18, p 2901 (2022)
Rationale: Infection with the SARS-CoV2 virus is associated with elevated neutrophil counts. Evidence of neutrophil dysfunction in COVID-19 is based on transcriptomics or single functional assays. Cell functions are interwoven pathways, and understan
Externí odkaz: https://doaj.org/article/6e499c61195847cd87688b285c0e40fd
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2
Frailty Is Associated With Neutrophil Dysfunction Which Is Correctable With Phosphoinositol-3-Kinase Inhibitors
Autor: Alice E Jasper, Thomas A Jackson, Helena Crisford, Elizabeth Sapey, Paul Newby, Janet M. Lord, Daisy Wilson, Peter Nightingale, William Drew
Publikováno v: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Neutrophil dysfunction has been described with age, appears exaggerated in infection, with altered phosphoinositol signaling a potential mechanism. However, functional aging is heterogeneous. Frailty is a negative health status and is more common in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666e9f4f42abbcae3dd7e3ccd18f00b3
https://doi.org/10.1093/gerona/glaa216
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3
S54 Elevated NETosis and migration but impaired anti-microbial responses in neutrophils from non-ICU, hospitalized COVID-19 patients
Autor: Michael J. Hughes, Frances Grudzinska, K. P. Yip, S. Thein, Alice E Jasper, J. Hazeldine, David R Thickett, Elizabeth Sapey, Aaron Scott, Kylie B. R. Belchamber, Dhruv Parekh
Publikováno v: Understanding COVID-19 mechanisms.
RationalInfection with the SARS-CoV2 virus is associated with elevated neutrophil counts. Evidence of neutrophil dysfunction in COVID-19 is based predominantly on transcriptomics or single functional assays. Cell functions are interwoven pathways, an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::617cf39a9ddf7885fad50905070b02fc
https://doi.org/10.1136/thorax-2021-btsabstracts.60
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5
Altered neutrophil phenotype and function in non-ICU hospitalised COVID-19 patients correlated with disease severity
Autor: Jon Hazeldine, Onn Shaun Thein, Alice E Jasper, Dhruv Parekh, Kay Por Yip, Michael J. Hughes, Kylie B. R. Belchamber, David R Thickett, Elizabeth Sapey, Aaron Scott, Frances Grudzinska
RationalInfection with the SARS-CoV2 virus is associated with elevated neutrophil counts. Evidence of neutrophil dysfunction in COVID-19 is based predominantly on transcriptomics or single functional assays. Cell functions are interwoven pathways, an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a304a76d831f379326e5945088f24904
https://doi.org/10.1101/2021.06.08.21258535
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6
Understanding potential mechanisms of harm: the drivers of electronic cigarette-induced changes in alveolar macrophages, neutrophils, and lung epithelial cells
Autor: Elizabeth Sapey, Alice E Jasper, David R Thickett, Aaron Scott
Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 321(2)
Electronic (e-) cigarettes are growing in popularity despite uncertainties regarding their long-term health implications. The link between cigarette smoking and initiation of chronic lung disease took decades to unpick so in vitro studies mimicking e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5fdd78ebf61c6679dca63efb37e8b01
https://pubmed.ncbi.nlm.nih.gov/34009037
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7
Mitigating Health Risks to Reopen a Clinical Research Laboratory During the COVID-19 Pandemic: A Framework (Preprint)
Autor: Eloise M Walker, Alice E Jasper, Lauren Davis, Kay Por Yip, Aduragbemi A Faniyi, Michael J Hughes, Helena A Crisford, Daniella A Spittle, Elizabeth Sapey, Kylie B R Belchamber, Aaron Scott
BACKGROUND The COVID-19 pandemic has led to many countries implementing lockdown procedures, resulting in the suspension of laboratory research. With lockdown measures now easing in some areas, many laboratories are preparing to reopen. This is parti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a3a4d4cbea700760563f1e96b25617b
https://doi.org/10.2196/preprints.22570
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S3 Exposure to electronic cigarette vapour induces functional changes in neutrophils which are more exaggerated by 4th generation devices
Autor: Alice E Jasper, Thickett, Aaron Scott, Elizabeth Sapey
Publikováno v: Smoking cessation strategies for lung health.
Background Despite uncertainties in their long term impact on lung health, the use of electronic-cigarettes (EC) has increased rapidly in recent years. In spite of the essential role of the neutrophil in the innate immune system, little is known abou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cb332c5ddaabdee496777261913e3e0
https://doi.org/10.1136/thorax-2019-btsabstracts2019.9
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