Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Alice Chen‐Plotkin"'
Autor:
Anantharaman Shantaraman, Eric B. Dammer, Obiadada Ugochukwu, Duc M. Duong, Luming Yin, E. Kathleen Carter, Marla Gearing, Alice Chen-Plotkin, Edward B. Lee, John Q. Trojanowski, David A. Bennett, James J. Lah, Allan I. Levey, Nicholas T. Seyfried, Lenora Higginbotham
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-24 (2024)
Abstract Lewy body dementia (LBD), a class of disorders comprising Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), features substantial clinical and pathological overlap with Alzheimer’s disease (AD). The identification of
Externí odkaz:
https://doaj.org/article/7ae7acdfdb7b4c38ba5851ba50f50b73
Autor:
Marta del Campo, Lisa Vermunt, Carel F. W. Peeters, Anne Sieben, Yanaika S. Hok-A-Hin, Alberto Lleó, Daniel Alcolea, Mirrelijn van Nee, Sebastiaan Engelborghs, Juliette L. van Alphen, Sanaz Arezoumandan, Alice Chen-Plotkin, David J. Irwin, Wiesje M. van der Flier, Afina W. Lemstra, Charlotte E. Teunissen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Diagnosis of dementia with Lewy bodies (DLB) is challenging and specific biofluid biomarkers are highly needed. We employed proximity extension-based assays to measure 665 proteins in the cerebrospinal fluid (CSF) from patients with DLB (n =
Externí odkaz:
https://doaj.org/article/6cdb0c30f54f4ba3839a04a756e80080
Autor:
Katheryn A. Q. Cousins, David J. Irwin, Alice Chen‐Plotkin, Leslie M. Shaw, Sanaz Arezoumandan, Edward B. Lee, David A. Wolk, Daniel Weintraub, Meredith Spindler, Andres Deik, Murray Grossman, Thomas F. Tropea
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 5, Pp 802-813 (2023)
Abstract Objective Within Lewy body spectrum disorders (LBSD) with α‐synuclein pathology (αSyn), concomitant Alzheimer's disease (AD) pathology is common and is predictive of clinical outcomes, including cognitive impairment and decline. Plasma p
Externí odkaz:
https://doaj.org/article/be506e0f18724aafa19268390fc0a285
Autor:
Maria Diaz-Ortiz, Nimansha Jain, Michael Gallagher, Marijan Posavi, Travis Unger, Alice Chen-Plotkin
Publikováno v:
Bio-Protocol, Vol 13, Iss 19 (2023)
Many single nucleotide polymorphisms (SNPs) identified by genome-wide association studies exert their effects on disease risk as expression quantitative trait loci (eQTL) via allele-specific expression (ASE). While databases for probing eQTLs in tiss
Externí odkaz:
https://doaj.org/article/24acd592cf36444da1cc4c8dd2a122c9
Autor:
Lara Blömeke, Marlene Pils, Victoria Kraemer-Schulien, Alexandra Dybala, Anja Schaffrath, Andreas Kulawik, Fabian Rehn, Anneliese Cousin, Volker Nischwitz, Johannes Willbold, Rebecca Zack, Thomas F. Tropea, Tuyen Bujnicki, Gültekin Tamgüney, Daniel Weintraub, David Irwin, Murray Grossman, David A. Wolk, John Q. Trojanowski, Oliver Bannach, Alice Chen-Plotkin, Dieter Willbold
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract The pathological hallmark of neurodegenerative diseases is the formation of toxic oligomers by proteins such as alpha-synuclein (aSyn) or microtubule-associated protein tau (Tau). Consequently, such oligomers are promising biomarker candidat
Externí odkaz:
https://doaj.org/article/bd2ce9d958844ee69807863970f7aacc
Autor:
Alba Cervantes González, David J. Irwin, Daniel Alcolea, Corey T. McMillan, Alice Chen-Plotkin, David Wolk, Sònia Sirisi, Oriol Dols-Icardo, Marta Querol-Vilaseca, Ignacio Illán-Gala, Miguel Angel Santos-Santos, Juan Fortea, Edward B. Lee, John Q. Trojanowski, Murray Grossman, Alberto Lleó, Olivia Belbin
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-12 (2022)
Abstract Background Synapse degeneration is an early event in pathological frontotemporal lobar degeneration (FTLD). Consequently, a surrogate marker of synapse loss could be used to monitor early pathologic changes in patients with underlying FTLD.
Externí odkaz:
https://doaj.org/article/9e38617f0aad47289a4630d1dc7afd9a
Autor:
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Publikováno v:
EBioMedicine, Vol 82, Iss , Pp 104179- (2022)
Summary: Background: Immunosenescence (ISC) describes age-related changes in immune-system composition and function. Multiple sclerosis (MS) is a lifelong inflammatory condition involving effector and regulatory T-cell imbalance, yet little is known
Externí odkaz:
https://doaj.org/article/d040e2c82e574e79b0794515fb8b9cb4
Autor:
Chia-Yu Chung, Amit Berson, Jason R. Kennerdell, Ashley Sartoris, Travis Unger, Sílvia Porta, Hyung-Jun Kim, Edwin R. Smith, Ali Shilatifard, Vivianna Van Deerlin, Virginia M.-Y. Lee, Alice Chen-Plotkin, Nancy M. Bonini
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
TDP-43 is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTD-TDP). Here, the authors identify the transcriptional elongation factor Ell as a strong modifier of TDP-43-mediated
Externí odkaz:
https://doaj.org/article/b2c2979de7ba485791653b7eba03aec1
Autor:
John L Robinson, Sharon X Xie, Daniel R Baer, EunRan Suh, Vivianna M Van Deerlin, Nicholas J Loh, David J Irwin, Corey T McMillan, David A Wolk, Alice Chen-Plotkin, Daniel Weintraub, Theresa Schuck, Virginia M Y Lee, John Q Trojanowski, Edward B Lee
Publikováno v:
Brain. 146:2557-2569
Pathologies that are causative for neurodegenerative disease (ND) are also frequently present in unimpaired, older individuals. In this retrospective study of 1647 autopsied individuals, we report the incidence of 10 pathologies across ND and normal
Autor:
Marta del Campo, Carel F. W. Peeters, Erik C. B. Johnson, Lisa Vermunt, Yanaika S. Hok-A-Hin, Mirrelijn van Nee, Alice Chen-Plotkin, David J. Irwin, William T. Hu, James J. Lah, Nicholas T. Seyfried, Eric B. Dammer, Gonzalo Herradon, Lieke H. Meeter, John van Swieten, Daniel Alcolea, Alberto Lleó, Allan I. Levey, Afina W. Lemstra, Yolande A. L. Pijnenburg, Pieter J. Visser, Betty M. Tijms, Wiesje M. van der Flier, Charlotte E. Teunissen
Publikováno v:
Nature aging, 2(11), 1040-+. Nature Publishing Group
del Campo, M, Peeters, C F W, Johnson, E C B, Vermunt, L, Hok-A-Hin, Y S, van Nee, M, Chen-Plotkin, A, Irwin, D J, Hu, W T, Lah, J J, Seyfried, N T, Dammer, E B, Herradon, G, Meeter, L H, van Swieten, J, Alcolea, D, Lleó, A, Levey, A I, Lemstra, A W, Pijnenburg, Y A L, Visser, P J, Tijms, B M, van der Flier, W M & Teunissen, C E 2022, ' CSF proteome profiling across the Alzheimer’s disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels ', Nature Aging, vol. 2, no. 11, pp. 1040-1053 . https://doi.org/10.1038/s43587-022-00300-1
Nature Aging, 2(11), 1040-1053
Nature Aging, 2(11), 1040-1053. Springer
Nature Aging 2 (2022) 11
del Campo, M, Peeters, C F W, Johnson, E C B, Vermunt, L, Hok-A-Hin, Y S, van Nee, M, Chen-Plotkin, A, Irwin, D J, Hu, W T, Lah, J J, Seyfried, N T, Dammer, E B, Herradon, G, Meeter, L H, van Swieten, J, Alcolea, D, Lleó, A, Levey, A I, Lemstra, A W, Pijnenburg, Y A L, Visser, P J, Tijms, B M, van der Flier, W M & Teunissen, C E 2022, ' CSF proteome profiling across the Alzheimer’s disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels ', Nature Aging, vol. 2, no. 11, pp. 1040-1053 . https://doi.org/10.1038/s43587-022-00300-1
Nature Aging, 2(11), 1040-1053
Nature Aging, 2(11), 1040-1053. Springer
Nature Aging 2 (2022) 11
Development of disease-modifying therapies against Alzheimer's disease (AD) requires biomarkers reflecting the diverse pathological pathways specific for AD. We measured 665 proteins in 797 cerebrospinal fluid (CSF) samples from patients with mild co