Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alice C L, Len"'
Publikováno v:
Clinical & Experimental Ophthalmology. 43:180-187
Background Diabetic macular oedema (DMO) is the commonest cause of vision loss in people with diabetes. Laser photocoagulation can be effective in the treatment of DMO; however, its mechanism of action is still poorly understood. A better understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca2c3179d3ceb9b7f15e31c5a8895455
https://doi.org/10.1111/ceo.12372
https://doi.org/10.1111/ceo.12372
Autor:
Gregory S. Hageman, Marcus Fruttiger, Michael B. Powner, Mark C Gillies, Ling Zhu, Xiaomin Song, Alice C. L. Len
Publikováno v:
Journal of Proteome Research. 11:537-553
We used the comparative proteomic technique iTRAQ coupled with offline 2DLC-MS/MS to analyze a rare specimen of the poorly understood, potentially blinding ophthalmic condition Macular Telangiectasia type 2 (MacTel type 2). We refined the technique u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd57d8a9ae33c1cdafa7a63c3c311404
https://doi.org/10.1021/pr200889t
https://doi.org/10.1021/pr200889t
Autor:
Alice C. L. Len, Paul A. Haynes, Mark S. Baker, Bengt Bjellqvist, Mark P. Molloy, Joel M. Chick
Publikováno v:
Journal of Proteome Research. 7:1036-1045
Membrane proteins are of particular interest in proteomics because of their potential therapeutic utility. Past proteomic approaches used to investigate membrane proteins have only been partially successful at providing a comprehensive analysis due t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fe400c54d496e84aff01da6083f2d7
https://doi.org/10.1021/pr700611w
https://doi.org/10.1021/pr700611w
Publikováno v:
Microbiology. 150:1353-1366
Two-dimensional gel electrophoretic analysis of the proteome ofStreptococcus mutansgrown at a steady state in a glucose-limited anaerobic continuous culture revealed a number of proteins that were differentially expressed when the growth pH was lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0fa663afa605626f4205f13fce558d
https://doi.org/10.1099/mic.0.26888-0
https://doi.org/10.1099/mic.0.26888-0
Publikováno v:
Microbiology. 150:1339-1351
Streptococcus mutansis an important pathogen in the initiation of dental caries as the bacterium remains metabolically active when the environment becomes acidic. The mechanisms underlying this ability to survive and proliferate at low pH remain an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3d6e45340ba6d3f07f19dc08625064
https://doi.org/10.1099/mic.0.27008-0
https://doi.org/10.1099/mic.0.27008-0
Publikováno v:
PROTEOMICS. 3:627-646
The oral pathogen, Streptococcus mutans, was grown under glucose limitation in a chemostat at pH 7.0 and a dilution rate of 0.1 h(-1) to mimic the conditions prevailing in a healthy human oral cavity in between meal times. Solubilized cellular and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b67e3c62bfa3f53fe5331a403c63b3e
https://doi.org/10.1002/pmic.200300391
https://doi.org/10.1002/pmic.200300391
Publikováno v:
Clinicalexperimental ophthalmology. 43(2)
Diabetic macular oedema (DMO) is the commonest cause of vision loss in people with diabetes. Laser photocoagulation can be effective in the treatment of DMO; however, its mechanism of action is still poorly understood. A better understanding of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29429b3a2188aaeb9f91c92bfd60e339
https://pubmed.ncbi.nlm.nih.gov/24978816
https://pubmed.ncbi.nlm.nih.gov/24978816
Publikováno v:
Retrovirology
Background Human Immunodeficiency Virus Type-1 (HIV-1), the main causative agent of Acquired Immunodeficiency Syndrome (AIDS) is a major global health problem. Cell-cell spread of HIV-1 between CD4 T cells confers many advantages including more rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0229d352228e472ff8cde8f7f62f193a
https://doi.org/10.1186/1742-4690-10-s1-p86
https://doi.org/10.1186/1742-4690-10-s1-p86
Autor:
Maxey C.M. Chung, Terence C.W. Poon, Pisana Rawson, Richard J. Simpson, Sai Ming Ngai, Yu-Ju Chen, Alice C. L. Len, Songfeng Wu, Ravi Sirdeshmukh, Jisnuson Svasti, Fuchu He, Phan Van Chi, Young-Ki Paik, Mark S. Baker, Florian S. Dreyer, T. William Jordan, Zongwei Cai, Min Seok Kwon, Eugene A. Kapp, Pu Jiang, Lifeng Peng, Chantragan Srisomsap, Yu-Chang Tyan, Nikhat Ahmed, David Fenyö, Kazuyuki Nakamura, Pao Chi Liao, Ying Jiang, Marie Isabel Aguilar, Tai-Long Pan, Danyl McLauchlan, Ghasem Hosseini Salekdeh
The Asia Oceania Human Proteome Organisation (AOHUPO) has embarked on a Membrane Proteomics Initiative with goals of systematic comparison of strategies for analysis of membrane proteomes and discovery of membrane proteins. This multilaboratory proje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11c85863b111f761adba1a5f20bf55f
https://europepmc.org/articles/PMC3891941/
https://europepmc.org/articles/PMC3891941/
Autor:
David A. Jones, Stuart J. Cordwell, Steven P. Djordjevic, Rachel G. Touma, Alice C. L. Len, Ben Crossett, Nichollas E. Scott, Angela Connolly, Linda Falconer
Publikováno v:
Proteomics. 8(1)
Campylobacter jejuni is the leading cause of food- and water-borne illness world-wide. The membrane-associated proteome of a recent C. jejuni gastrointestinal isolate (JHH1) was generated by sodium carbonate precipitation and ultracentrifugation foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f73eca53293056bb8fc78ecde45af5
https://pubmed.ncbi.nlm.nih.gov/18095373
https://pubmed.ncbi.nlm.nih.gov/18095373