Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alice C, Newman"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Macroautophagy can regulate cell signalling and tumorigenesis but the molecular mechanisms are unclear. Here the authors show selective degradation of the signalling scaffold TRAF3 by autophagy and consequent activation of the NF-κB family member RE
Externí odkaz:
https://doaj.org/article/517692c5851844229fcf533d939a706e
Autor:
Mattia Falcone, Alejandro Huerta Uribe, Vasileios Papalazarou, Alice C. Newman, Dimitris Athineos, Katrina Stevenson, Charles-Etienne Gabriel Sauvé, Yajing Gao, Jin K. Kim, Michael Del Latto, Maria Kierstead, Chao Wu, J. Joshua Smith, Paul B. Romesser, Anthony J. Chalmers, Karen Blyth, Oliver D. K. Maddocks
Publikováno v:
British Journal of Cancer. 127:1773-1786
Background Cellular metabolism is an integral component of cellular adaptation to stress, playing a pivotal role in the resistance of cancer cells to various treatment modalities, including radiotherapy. In response to radiotherapy, cancer cells enga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1385c6eef7b39544a8e10a2a4128d740
https://doi.org/10.1038/s41416-022-01965-6
https://doi.org/10.1038/s41416-022-01965-6
Autor:
Tong, Zhang, Christin, Bauer, Alice C, Newman, Alejandro Huerta, Uribe, Dimitris, Athineos, Karen, Blyth, Oliver D K, Maddocks
Publikováno v:
Nature metabolism. 2(10)
Cancer cells have high demands for non-essential amino acids (NEAAs), which are precursors for anabolic and antioxidant pathways that support cell survival and proliferation. It is well-established that cancer cells consume the NEAA cysteine, and tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bda1549cc2619a7fa8247d45ac98e398
https://pubmed.ncbi.nlm.nih.gov/32747794
https://pubmed.ncbi.nlm.nih.gov/32747794
Autor:
Dimitris Athineos, Oliver D. K. Maddocks, Tong Zhang, Karen Blyth, Alice C Newman, Mattia Falcone, Matthias Pietzke, Alexei Vazquez, Alejandro Huerta Uribe
Publikováno v:
Molecular Cell
Summary Cancer cells adapt their metabolism to support elevated energetic and anabolic demands of proliferation. Folate-dependent one-carbon metabolism is a critical metabolic process underpinning cellular proliferation supplying carbons for the synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f5ec6918eade7592e7491459e0ebaf
https://pubmed.ncbi.nlm.nih.gov/33831358
https://pubmed.ncbi.nlm.nih.gov/33831358
Autor:
Alice C Newman, Caroline L Scholefield, Alain J Kemp, Michelle Newman, Edward G McIver, Ahmad Kamal, Simon Wilkinson
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50672 (2012)
K-Ras dependent non-small cell lung cancer (NSCLC) cells are 'addicted' to basal autophagy that reprograms cellular metabolism in a lysosomal-sensitive manner. Here we demonstrate that the xenophagy-associated kinase TBK1 drives basal autophagy, cons
Externí odkaz:
https://doaj.org/article/98c61e704c564ad7bd714b425a344b0d
Autor:
Oliver D. K. Maddocks, Alice C Newman
Publikováno v:
Trends in Cell Biology. 27:645-657
Folate metabolism functions to supply one-carbon units that are vital for a range of biochemical reactions. Cancer cells can utilise serine as a major source of one-carbon units, rendering them dependent upon extracellular serine uptake or de novo se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1189f33451e80349d6a34886bcc8e917
https://doi.org/10.1016/j.tcb.2017.05.001
https://doi.org/10.1016/j.tcb.2017.05.001
Publikováno v:
Methods in Molecular Biology ISBN: 9781493990269
Tracing the fate of carbon-13 (13C) labeled metabolites within cells by liquid chromatography mass spectrometry (LCMS) is a powerful analytical technique used for many years in the study of cell metabolism. Conventional experiments using LCMS and lab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e30bb5b0b892c5415f35b2e8cb8a6328
https://doi.org/10.1007/978-1-4939-9027-6_4
https://doi.org/10.1007/978-1-4939-9027-6_4
Autor:
Oliver D. K. Maddocks, Alice C Newman
Publikováno v:
British Journal of Cancer
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells. As such, anti-folates, drugs that target one-carbon metabolism, have long been used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbadf98bbfb73f34b4096b583a700f1
https://eprints.gla.ac.uk/141034/7/141034.pdf
https://eprints.gla.ac.uk/141034/7/141034.pdf
Publikováno v:
Geological Society of America Abstracts with Programs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43416b0ed71a37d323c0cef05f82b230
https://doi.org/10.1130/abs/2016am-286419
https://doi.org/10.1130/abs/2016am-286419
Autor:
Jérôme Nicod, Pippa A. Thomson, David J. Porteous, Helen S. Torrance, Kathryn L. Evans, Susan Anderson, Pelagia Derizioti, Alison E. Hill, Rosie M. Walker, Alice C. Newman, Simon E. Fisher, Sonja C. Vernes, Fumiaki Ogawa, Gillian Hamilton
Publikováno v:
Human Molecular Genetics
Disrupted in schizophrenia 1 (DISC1) is a leading candidate susceptibility gene for schizophrenia, bipolar disorder and recurrent major depression, which has been implicated in other psychiatric illnesses of neurodevelopmental origin, including autis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783ccf68df01098a007a01d46e832db0
https://hdl.handle.net/11858/00-001M-0000-000F-51B9-E21.11116/0000-0003-8A10-F
https://hdl.handle.net/11858/00-001M-0000-000F-51B9-E21.11116/0000-0003-8A10-F