Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alice Ban Ke"'
Autor:
Peter J. Kilford, Kuan‐Fu Chen, Kim Crewe, Iain Gardner, Oliver Hatley, Alice Ban Ke, Sibylle Neuhoff, Mian Zhang, Karen Rowland Yeo
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 7, Pp 822-832 (2022)
Abstract Physiologically‐based pharmacokinetic (PBPK) modeling is being increasingly used in drug development to avoid unnecessary clinical drug–drug interaction (DDI) studies and inform drug labels. Thus, regulatory agencies are recommending, or
Externí odkaz:
https://doaj.org/article/5516ed2a72b542b39b08ffd22bd4d60c
Autor:
Laura Oggianu, Giorgio Di Dato, Giorgina Mangano, Maria Teresa Rosignoli, Savannah McFeely, Alice Ban Ke, Hannah M. Jones, Alessandro Comandini
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 6, Pp 1417-1429 (2022)
Abstract Trazodone is approved for the treatment of major depressive disorders, marketed as immediate release (IR), prolonged release, and once a day (OAD) formulation. The different formulations allow different administration schedules and may be us
Externí odkaz:
https://doaj.org/article/d9d926ebb4ce4587b933ee559be1a693
Autor:
Mark A. Milad, Alice Ban Ke
Publikováno v:
Clinical Pharmacology & Therapeutics. 106:164-173
Betamethasone and dexamethasone are the most widely studied antenatal corticosteroids (ACS) administered to pregnant women, just prior to the birth of a preterm neonate, to accelerate fetal lung maturation. Although betamethasone, predominantly used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f13d81b6eda2d6c977ea552566ec72
https://doi.org/10.1002/cpt.1438
https://doi.org/10.1002/cpt.1438
Autor:
Alice Ban Ke, Lisa Almond, Hannah M. Jones, David Wesche, Mian Zhang, Xian Pan, Karen Rowland Yeo
Publikováno v:
Clinical Pharmacology & Therapeutics
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
We use a mechanistic lung model to demonstrate that accumulation of chloroquine (CQ), hydroxychloroquine (HCQ), and azithromycin (AZ) in the lungs is sensitive to changes in lung pH, a parameter that can be affected in patients with coronavirus disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3b5d67c52ccebe9bf961f567c33efd
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 7:103-110
The unmet medical need of providing evidence-based pharmacotherapy for pregnant women is recognized by the regulatory bodies. Physiologically based pharmacokinetic (PBPK) modeling offers an attractive platform to quantify anticipated changes in the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6ae64c657cea5cd9a272d01ac4f6e4
https://doi.org/10.1002/psp4.12274
https://doi.org/10.1002/psp4.12274
Publikováno v:
European Journal of Pharmaceutical Sciences. 150:105355
Paclitaxel is the backbone of standard chemotherapeutic regimens used in a number of malignancies and is frequently given with concomitant medications. Newly developed oncolytic agents, including tyrosine kinase inhibitors are often shown to be CYP3A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78564d4683b7c5fc17091757153f40f6
https://doi.org/10.1016/j.ejps.2020.105355
https://doi.org/10.1016/j.ejps.2020.105355
Autor:
Nathan Bryan Mantlo, Stephen D. Hall, Stuart Friedrich, Matthew Rotelli, Alice Ban Ke, David S. Small
Publikováno v:
The Journal of Clinical Pharmacology. 55:757-767
Anacetrapib, a cholesterol ester transfer protein (CETP) inhibitor, has been reported to have longer elimination half-life after longer treatment. Two pharmacokinetic model-based approaches were used to assess whether evacetrapib, another CETP inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de10d9a7ddf9d57b1ec1982284c5681f
https://doi.org/10.1002/jcph.472
https://doi.org/10.1002/jcph.472
Publikováno v:
British Journal of Clinical Pharmacology. 77:554-570
Aim Conducting PK studies in pregnant women is challenging. Therefore, we asked if a physiologically-based pharmacokinetic (PBPK) model could be used to predict the disposition in pregnant women of drugs cleared by multiple CYP enzymes. Methods We ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::343f90dbc0d6df3910d22b4fea42ffe3
https://doi.org/10.1111/bcp.12207
https://doi.org/10.1111/bcp.12207
Autor:
David S, Small, Alice Ban, Ke, Stephen D, Hall, Nathan, Mantlo, Matthew, Rotelli, Stuart, Friedrich
Publikováno v:
Journal of clinical pharmacology. 55(7)
Anacetrapib, a cholesterol ester transfer protein (CETP) inhibitor, has been reported to have longer elimination half-life after longer treatment. Two pharmacokinetic model-based approaches were used to assess whether evacetrapib, another CETP inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::329199cc53f04f1550a071f0a1dadd57
https://pubmed.ncbi.nlm.nih.gov/25651523
https://pubmed.ncbi.nlm.nih.gov/25651523
Publikováno v:
Annual review of pharmacology and toxicology. 54
Pregnant women and their fetuses are orphan populations with respect to the safety and efficacy of drugs. Physiological and absorption, distribution, metabolism, and excretion (ADME) changes during pregnancy can significantly affect drug pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3804a56822ed9f2452799f7513098b
https://pubmed.ncbi.nlm.nih.gov/24392692
https://pubmed.ncbi.nlm.nih.gov/24392692