Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alice B. Ke"'
Autor:
Laura Oggianu, Alice B. Ke, Manoranjenni Chetty, Rossella Picollo, Vanessa Petrucci, Fabrizio Calisti, Fabio Garofolo, Serena Tongiani
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 2, Pp 77-86 (2020)
There is a paucity of clinical trials for the treatment of pediatric insomnia. This study was designed to predict the doses of trazodone to guide dosing in a clinical trial for pediatric insomnia using physiologically‐based pharmacokinetic (PBPK) m
Externí odkaz:
https://doaj.org/article/3a09e59d97bc467f9ba4516cc214b313
Autor:
Fabio Garofolo, Serena Tongiani, Vanessa Petrucci, Fabrizio Calisti, Alice B Ke, Laura Oggianu, Rossella Picollo, Manoranjenni Chetty
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 2, Pp 77-86 (2020)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
There is a paucity of clinical trials for the treatment of pediatric insomnia. This study was designed to predict the doses of trazodone to guide dosing in a clinical trial for pediatric insomnia using physiologically-based pharmacokinetic (PBPK) mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7309e5ef45a4ccab0cc7a5878a21f5
https://doaj.org/article/3a09e59d97bc467f9ba4516cc214b313
https://doaj.org/article/3a09e59d97bc467f9ba4516cc214b313
Autor:
Alice B. Ke, Trevor N. Johnson
Publikováno v:
The Journal of Clinical Pharmacology. 61
Developing medicines for children is now established in legislation in both the United States and Europe; new drugs require pediatric study or investigation plans as part of their development. Particularly in early age groups, many developmental proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26fefc1d115f78d9fbdbc14f450c636
https://doi.org/10.1002/jcph.1834
https://doi.org/10.1002/jcph.1834
Publikováno v:
Clinical Pharmacology & Therapeutics. 95:473-476
High-dose ketoconazole (400 mg q.d. for ≥5 days) has been the gold-standard strong cytochrome P450 3A (CYP3A) inhibitor in drug development drug–drug interaction (DDI) studies. In 2013, the US Food and Drug Administration (FDA) and the European M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1366a6395ab32dca1d80f74df8a834
https://doi.org/10.1038/clpt.2014.41
https://doi.org/10.1038/clpt.2014.41
Autor:
J. William Higgins, Philip C. Smith, John K. Fallon, Jason Manro, Jing Q. Bao, Alice B. Ke, Maciej J. Zamek-Gliszczynski
Publikováno v:
Drug Metabolism and Disposition. 42:182-192
Although organic anion transporting polypeptide (OATP)-mediated hepatic uptake is generally conserved between rodents and humans at a gross pharmacokinetic level, the presence of three major hepatic OATPs with broad overlap in substrate and inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c981f551ffd4c1897884592bb618d8d
https://doi.org/10.1124/dmd.113.054783
https://doi.org/10.1124/dmd.113.054783
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 354(2)
Blood cells are considered an important distributional compartment for metformin based on the high blood-to-plasma partition ratio (B/P) in humans (>10 at Cmin). However, literature reports of metformin's intrinsic in vitro B/P values are lacking. At
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1a3c516ca78408df93f2f8d4257530
https://pubmed.ncbi.nlm.nih.gov/26062557
https://pubmed.ncbi.nlm.nih.gov/26062557
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 42(11)
Ketoconazole is no longer available for clinical determination of worst-case victim drug-drug interaction (DDI) potential for cytochrome P450 3A (CYP3A)-substrate drugs; clarithromycin and itraconazole are the proposed replacements. Ketoconazole DDIs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ea24d15ff8451b12c5d58e66d536e4
https://pubmed.ncbi.nlm.nih.gov/25106415
https://pubmed.ncbi.nlm.nih.gov/25106415
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 42(6)
The glycogen synthase kinase-3 inhibitor LY2090314 specifically impaired CYP2B6 activity during in vitro evaluation of cytochrome P450 (P450) enzyme induction in human hepatocytes. CYP2B6 catalytic activity was significantly decreased following 3-day
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91406a06d1583cfe4eeeddd410b082e9
https://pubmed.ncbi.nlm.nih.gov/24658455
https://pubmed.ncbi.nlm.nih.gov/24658455
Autor:
Anjali Pandey, John T. Curnutte, Glenn C. Michelson, Pam B. Conley, Alice B. Ke, Janet M. Leeds, Karen Rowland Yeo, Greg Coffey
Publikováno v:
Cancer Research. 76:CT144-CT144
Background. Subsets of B cell lymphomas appear to rely on B-cell receptor (BCR) and/or cytokine JAK/STAT signaling for survival. SYK is upstream of BTK, PI3Kδ, and PLCγ2 on the BCR signaling pathway, and thus a potential therapeutic target. Additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96fa6b7f0d3c41ab2830646f110d0e57
https://doi.org/10.1158/1538-7445.am2016-ct144
https://doi.org/10.1158/1538-7445.am2016-ct144
Autor:
Alice B. Kelly, Nina Maggi Kelly
Publikováno v:
Remote Sensing, Vol 6, Iss 12, Pp 12723-12751 (2014)
This paper explores the existing literature on the active detection of crimes using remote sensing technologies. The paper reviews sixty-one studies that use remote sensing to actively detect crime. Considering the serious consequences of misidentify
Externí odkaz:
https://doaj.org/article/6881d509f9624a859a8d62103fe6214a