Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alice A. Holazo"'
Publikováno v:
Journal of Pharmaceutical Sciences. 65:822-827
The physiological basis for the reduced levodopa bioavailability following oral administration was investigated. Four dogs received single 25-mg/kg doses of 14 C-levodopa on three separate occasions in a crossover fashion via hepatoportal catheter, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d14964190962891b218f158b16de3b
https://doi.org/10.1002/jps.2600650607
https://doi.org/10.1002/jps.2600650607
Autor:
Alice A. Holazo, M.L. Jack, R.L. Young, Robert E. Weinfeld, A. Liebman, S. A. Kaplan, W.R. Dixon, K. Alexander
Publikováno v:
Journal of Pharmaceutical Sciences. 65:701-704
A simple, specific, and sensitive radioimmunoassay was developed for the determination of the diuretic bumetanide in plasma and urine. Antiserum to bumetanide was obtained from rabbits immunized with an immunogen prepared by covalently coupling the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1136d6209f85015f5c7d069161d9893f
https://doi.org/10.1002/jps.2600650518
https://doi.org/10.1002/jps.2600650518
Publikováno v:
Journal of Pharmaceutical Sciences. 73:1108-1113
The pharmacokinetics of bumetanide was studied in 12 normal subjects after 1-mg intravenous, intramuscular, oral solution, and tablet administrations in a random four-treatment crossover design. Plasma and urine concentrations of intact bumetanide we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4dd477e3ceed2148aa914f7ebb3c2c9
https://doi.org/10.1002/jps.2600730821
https://doi.org/10.1002/jps.2600730821
Publikováno v:
The Journal of Clinical Pharmacology. 26:336-345
The plasma concentration and antiarrhythmic effect data following multiple, ascending oral doses of cibenzoline in four patients with frequent premature ventricular contractions (PVCs) were analyzed using pharmacokinetic and pharmacodynamic modeling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601ebe70d5010e32a5a1cfaee27e2336
https://doi.org/10.1002/j.1552-4604.1986.tb03535.x
https://doi.org/10.1002/j.1552-4604.1986.tb03535.x
Autor:
R.L. Young, Alice A. Holazo, S. A. Kaplan, Ross Dixon, Mia Parsonnet, David H. Malarek, James D. Moore, Erno Mohacsi, H. G. Boxenbaum
Publikováno v:
Clinical Pharmacology & Therapeutics. 24:622-627
The pharmacokinetic profile of (-)-2-hydroxy-N-cyclopropylmethylmorphinan (HCMM), a narcotic antagonist and analgesic, has been evaluated in man following administration of 25 to 50 mg of the drug orally and 10 to 15 mg intramuscularly. A specific ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa8987fbbd7dbace5e78b8614bc6dc6
https://doi.org/10.1002/cpt1978245622
https://doi.org/10.1002/cpt1978245622
Publikováno v:
Journal of Pharmaceutical Sciences. 65:1827-1831
A specific method was developed for the determination of l-2-hydroxy-N-cyclopropylmethylmorphinan in plasma and urine by GLC, using flame-ionization detection. The method involves the extraction of the compound into ether from plasma or urine at pH 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350fb0565cb9a0b5d41bdaa7fa6b11aa
https://doi.org/10.1002/jps.2600651232
https://doi.org/10.1002/jps.2600651232
Publikováno v:
The Journal of Clinical Pharmacology. 28:1040-1045
The effects of age, gender and low-dose (50 mcg or less) oral contraceptive steroids (OCS) on the pharmacokinetics of midazolam were evaluated following a single 7.5 mg intramuscular dose to five groups (8/group) of healthy volunteers consisting of y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebefbc242703928a2916c729825705f0
https://doi.org/10.1002/j.1552-4604.1988.tb03127.x
https://doi.org/10.1002/j.1552-4604.1988.tb03127.x
Publikováno v:
The Journal of Clinical Pharmacology. 26:71-73
Differences in the potency of intravenous (IV) and oral verapamil have recently been reported with the concentration-response curve for PR-interval prolongation being shifted further to the right following oral administration relative to IV administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d63d12fc326064878b1e7dfc9345d40
https://doi.org/10.1002/j.1552-4604.1986.tb02906.x
https://doi.org/10.1002/j.1552-4604.1986.tb02906.x
Autor:
Alice A. Holazo, Wayne A. Colburn
Publikováno v:
Drug metabolism reviews. 13(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66d7716e301f112bcfa79e3506d81cc
https://pubmed.ncbi.nlm.nih.gov/7128457
https://pubmed.ncbi.nlm.nih.gov/7128457
Autor:
F. Gilbert McMahon, John J. Konikoff, Susan S. Chen, Jerome R. Ryan, Alice A. Holazo, Romulus K. Brazzell
Publikováno v:
Journal of clinical pharmacology. 25(2)
The pharmacokinetics of the investigational agent carprofen were examined in 12 patients with liver dysfunction (hepatic cirrhosis) and in six normal volunteers following single 100-mg oral administration of carprofen. In addition, three patients wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a3bb6864c668716744bdffac105c46
https://pubmed.ncbi.nlm.nih.gov/3886707
https://pubmed.ncbi.nlm.nih.gov/3886707