Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Alice, Biosa"'
Autor:
Isabella Russo, Alice Kaganovich, Jinhui Ding, Natalie Landeck, Adamantios Mamais, Tatiana Varanita, Alice Biosa, Isabella Tessari, Luigi Bubacco, Elisa Greggio, Mark R. Cookson
Publikováno v:
Neurobiology of Disease, Vol 129, Iss , Pp 67-78 (2019)
Several previous studies have linked the Parkinson's disease (PD) gene LRRK2 to the biology of microglia cells. However, the precise ways in which LRRK2 affects microglial function have not been fully resolved. Here, we used the RNA-Sequencing to obt
Externí odkaz:
https://doaj.org/article/6c52926ffb4e4d618de34aace75d741d
Autor:
Alice Biosa, Federica Sandrelli, Mariano Beltramini, Elisa Greggio, Luigi Bubacco, Marco Bisaglia
Publikováno v:
Neurobiology of Disease, Vol 108, Iss , Pp 65-72 (2017)
Several mutations in the gene coding for DJ-1 have been associated with early onset forms of parkinsonism. In spite of the massive effort spent by the scientific community in understanding the physiological role of DJ-1, a consensus on what DJ-1 actu
Externí odkaz:
https://doaj.org/article/f620ea986be1406489495b9907193569
Autor:
Lucia Iannotta, Alice Biosa, Jillian H. Kluss, Giulia Tombesi, Alice Kaganovich, Susanna Cogo, Nicoletta Plotegher, Laura Civiero, Evy Lobbestael, Veerle Baekelandt, Mark R. Cookson, Elisa Greggio
Publikováno v:
Cells, Vol 9, Iss 11, p 2344 (2020)
Mutations in LRRK2 cause familial Parkinson’s disease and common variants increase disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by phosphorylation of key residues, primarily Ser1292 and Ser935, which impacts d
Externí odkaz:
https://doaj.org/article/78911e6a062a4ca7b72b2e966e8e80cc
Autor:
Maria Perez Carrion, Francesca Pischedda, Alice Biosa, Isabella Russo, Letizia Straniero, Laura Civiero, Marianna Guida, Christian J. Gloeckner, Nicola Ticozzi, Cinzia Tiloca, Claudio Mariani, Gianni Pezzoli, Stefano Duga, Irene Pichler, Lifeng Pan, John E. Landers, Elisa Greggio, Michael W. Hess, Stefano Goldwurm, Giovanni Piccoli
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Mutations in leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and sporadic Parkinson’s disease (PD). LRRK2 is a complex protein that consists of multiple domains, including 13 putative armadillo-type repeats at the N-terminus.
Externí odkaz:
https://doaj.org/article/966cd6a9f2404d1fad07e6bf77e844ea
Autor:
Mauro Rassu, Maria Grazia Del Giudice, Simona Sanna, Jean Marc Taymans, Michele Morari, Alberto Brugnoli, Martina Frassineti, Alessandra Masala, Sonia Esposito, Manuela Galioto, Cristiana Valle, Maria Teresa Carri, Alice Biosa, Elisa Greggio, Claudia Crosio, Ciro Iaccarino
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179082 (2017)
Mutations in LRRK2 play a critical role in both familial and sporadic Parkinson's disease (PD). Up to date, the role of LRRK2 in PD onset and progression remains largely unknown. However, experimental evidence highlights a critical role of LRRK2 in t
Externí odkaz:
https://doaj.org/article/0a7431806839439092778c00ee0bc4a3
Autor:
Federica De Lazzari, Mariano Beltramini, Luigi Bubacco, Marco Bisaglia, Alice Biosa, Nicoletta Plotegher, Roberta Filograna, Anna Masato
Publikováno v:
Neurotoxicity Research. 36:746-755
The preferential loss of dopaminergic neurons in the substantia nigra pars compacta is one of the pathological hallmarks characterizing Parkinson's disease. Although the pathogenesis of this disorder is not fully understood, oxidative stress plays a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe05fdb750483484f498319025d3845
https://doi.org/10.1007/s12640-019-00078-y
https://doi.org/10.1007/s12640-019-00078-y
Autor:
Michele Sandre, Francesca Pischedda, Maria Perez Carrion, Maria Daniela Cirnaru, Alice Biosa, Lifeng Pan, Elisa Greggio, Rina Bandopadhyay, Luisa Ponzoni, Mariaelvina Sala, Oriano Marin, Michele Morari, Giovanni Piccoli
SummaryParkinson’s disease (PD) is characterized by the progressive degeneration of dopaminergic neurons within the substantia nigra pars compacta and the presence of protein aggregates in surviving neurons. LRRK2 G2019S mutation is one of the majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49034bca76cc4d86c084cea6aa1eccfb
https://hdl.handle.net/11392/2471966
https://hdl.handle.net/11392/2471966
Autor:
Rossana Migheli, Maria Grazia Del Giudice, Ylenia Spissu, Giovanna Sanna, Yulan Xiong, Ted M Dawson, Valina L Dawson, Manuela Galioto, Gaia Rocchitta, Alice Biosa, Pier Andrea Serra, Maria Teresa Carri, Claudia Crosio, Ciro Iaccarino
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77198 (2013)
The leucine-rich repeat kinase 2 (LRRK2) gene was found to play a role in the pathogenesis of both familial and sporadic Parkinson's disease (PD). LRRK2 encodes a large multi-domain protein that is expressed in different tissues. To date, the physiol
Externí odkaz:
https://doaj.org/article/656bc98dac474b0180d333ec207576ee
Autor:
Laura Civiero, Alice Kaganovich, Giulia Tombesi, Lucia Iannotta, Mark R. Cookson, Nicoletta Plotegher, Veerle Baekelandt, Evy Lobbestael, Susanna Cogo, Alice Biosa, Jillian H. Kluss, Elisa Greggio
Publikováno v:
Cells
Cells, Vol 9, Iss 2344, p 2344 (2020)
Volume 9
Issue 11
Cells, Vol 9, Iss 2344, p 2344 (2020)
Volume 9
Issue 11
Mutations in LRRK2 cause familial Parkinson&rsquo
s disease and common variants increase disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by phosphorylation of key residues, primarily Ser1292 and Ser935, which
s disease and common variants increase disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by phosphorylation of key residues, primarily Ser1292 and Ser935, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9753b174fffec26a43d0db5bc0b26585
https://lirias.kuleuven.be/handle/123456789/667732
https://lirias.kuleuven.be/handle/123456789/667732
Publikováno v:
Biochemical Society Transactions. 46:1653-1663
Leucine-rich repeat kinase 2 (LRRK2), a complex kinase/GTPase mutated in Parkinson's disease, has been shown to physically and functionally interact with cytoskeletal-related components in different brain cells. Neurons greatly rely on a functional c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90421047c649fd6297b19664f931ddd6
https://doi.org/10.1042/bst20180469
https://doi.org/10.1042/bst20180469