Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Alican Gulsevin"'
Publikováno v:
Pharmacological Research, Vol 190, Iss , Pp 106736- (2023)
We discuss models for the activation and desensitization of α7 nicotinic acetylcholine receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators (PAMs) that destabilize α7 desensitized states. Type II PAMs such as PNU
Externí odkaz:
https://doaj.org/article/ff84c7fc09c649549e6b17ec2d68b6df
Autor:
Alican Gulsevin, Jens Meiler
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008818 (2021)
Amphipathic helices have hydrophobic and hydrophilic/charged residues situated on opposite faces of the helix. They can anchor peripheral membrane proteins to the membrane, be attached to integral membrane proteins, or exist as independent peptides.
Externí odkaz:
https://doaj.org/article/465934a3d0804820a4401e4346c360bc
Autor:
Alican Gulsevin, Andrew M. Glazer, Tiffany Shields, Brett M. Kroncke, Dan M. Roden, Jens Meiler
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2225 (2022)
The cardiac sodium ion channel (NaV1.5) is a protein with four domains (DI-DIV), each with six transmembrane segments. Its opening and subsequent inactivation results in the brief rapid influx of Na+ ions resulting in the depolarization of cardiomyoc
Externí odkaz:
https://doaj.org/article/847f3f6bac334da08828c78d359258f1
Autor:
Alican Gulsevin, Roger L. Papke, Clare Stokes, Hue N. T. Tran, Aihua H. Jin, Irina Vetter, Jens Meiler
Publikováno v:
Toxins, Vol 13, Iss 8, p 555 (2021)
α-conotoxins are 13–19 amino acid toxin peptides that bind various nicotinic acetylcholine receptor (nAChR) subtypes. α-conotoxin Mr1.7c (MrIC) is a 17 amino acid peptide that targets α7 nAChR. Although MrIC has no activating effect on α7 nAChR
Externí odkaz:
https://doaj.org/article/59b9fd8bde3d41f1acc5a78ea6fe96a6
Autor:
Alican Gulsevin, Jens Meiler
Publikováno v:
Toxins, Vol 12, Iss 9, p 598 (2020)
Three-finger toxins (3FTX) are a group of peptides that affect multiple receptor types. One group of proteins affected by 3FTX are nicotinic acetylcholine receptors (nAChR). Structural information on how neurotoxins interact with nAChR is limited and
Externí odkaz:
https://doaj.org/article/d51f04e433084452a1ec5b31a7db0c10
Autor:
Bing Han, Alican Gulsevin, Sarah Connolly, Ting Wang, Brigitte Meyer, Jason Porta, Ajit Tiwari, Angie Deng, Louise Chang, Yelena Peskova, Hassane S. Mchaourab, Erkan Karakas, Melanie D. Ohi, Jens Meiler, Anne K. Kenworthy
Publikováno v:
J Biol Chem
Caveolin-1 (CAV1) is a membrane-sculpting protein that oligomerizes to generate flask-shaped invaginations of the plasma membrane known as caveolae. Mutations in CAV1 have been linked to multiple diseases in humans. Such mutations often interfere wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3262e8a2bce0ab029daea8a71ff1d5f7
https://europepmc.org/articles/PMC10124911/
https://europepmc.org/articles/PMC10124911/
Caveolins are a unique family of membrane remodeling proteins essential for building flaskshaped nanoscale plasma membrane invaginations that regulate signaling and stress responses in vertebrates known as caveolae. Recent evidence suggests that to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3fb7037da904768291355bfe88b7a9f
https://doi.org/10.1101/2022.11.15.516482
https://doi.org/10.1101/2022.11.15.516482
Autor:
Alican Gulsevin, Bing Han, Jason C. Porta, Hassane S. Mchaourab, Jens Meiler, Anne K. Kenworthy
Publikováno v:
Biophysical Journal.
AlphaFold2 (AF2) has revolutionized the field of protein structural prediction. Here, we test its ability to predict the tertiary and quaternary structure of a previously undescribed scaffold with new folds and unusual architecture, the monotopic mem
Autor:
Bing Han, Alican Gulsevin, Sarah Connolly, Ting Wang, Jason Porta, Ajit Tiwari, Angie Deng, Louise Chang, Yelena Peskova, Hassane S. Mchaoraub, Erkan Karakas, Melanie D. Ohi, Jens Meiler, Anne K. Kenworthy
Caveolin-1 (CAV1) is a membrane sculpting protein that oligomerizes to generate flask-shaped invaginations of the plasma membrane known as caveolae. Mutations in CAV1 have been linked to multiple diseases in humans. Such mutations often interfere wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a42426e08b7edda734d500b5872ad5dd
https://doi.org/10.1101/2022.05.23.493104
https://doi.org/10.1101/2022.05.23.493104
Autor:
Jason C. Porta, Bing Han, Alican Gulsevin, Jeong Min Chung, Yelena Peskova, Sarah Connolly, Hassane S. Mchaourab, Jens Meiler, Erkan Karakas, Anne K. Kenworthy, Melanie D. Ohi
Publikováno v:
Science advances. 8(19)
Membrane sculpting proteins shape the morphology of cell membranes and facilitate remodeling in response to physiological and environmental cues. Complexes of the monotopic membrane protein caveolin function as essential curvature-generating componen