Modulating the HSP90 control over NFκB/NLRP3/Caspase-1 axis is a new therapeutic target in the management of liver fibrosis: Insights into the role of TAS-116 (Pimitespib).

Autor: Elmorsy EA; Department of Pharmacology and Therapeutics, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia; Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt. Electronic address: a.almarsa@qu.edu.sa., Saber S; Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt. Electronic address: sameh.saber@deltauniv.edu.eg., Hamad RS; Biological Sciences Department, College of Science, King Faisal University, Al Ahsa 31982, Saudi Arabia; Central Laboratory, Theodor Bilharz Research Institute, Giza 12411, Egypt. Electronic address: rhamad@kfu.edu.sa., Abdel-Reheim MA; Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni Suef 62521, Egypt. Electronic address: m.ahmed@su.edu.sa., Nadwa EH; Department of Pharmacology and Therapeutics, College of Medicine, Jouf University, Sakaka, Saudi Arabia; Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Cairo 11562, Egypt. Electronic address: ehnadwa@ju.edu.sa., Alibrahim AOE; Department of Internal Medicine, College of Medicine, Jouf University, Sakaka, Saudi Arabia. Electronic address: aoalbrahim@ju.edu.sa., Alkhamiss AS; Department of Pathology, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia. Electronic address: akhamiss@qumc.edu.sa., AlSalloom AA; Department of Pathology, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia. Electronic address: aaslom@qu.edu.sa., Mohamed EA; Department of Anatomy, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia; Department of Anatomy, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: e.abdelmeguid@qu.edu.sa., Nour-El-Din M; Department of Anatomy, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia. Electronic address: msaalh@qu.edu.sa., Amer MM; Department of Anatomy, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia; Department of Anatomy and Embryology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: m.amer@qu.edu.sa., Abdel-Hamed MR; Department of Anatomy, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia; Department of Anatomy and Embryology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: m.younes@qu.edu.sa., Mohamed NB; Department of Pathology, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia. Electronic address: nb.mohamed@qu.edu.sa., Abozaid L; Department of Pathology, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia. Electronic address: l.abozaid@qu.edu.sa., Mostafa-Hedeab G; Department of Pharmacology and Therapeutics, College of Medicine, Jouf University, Sakaka, Saudi Arabia; Pharmacology Department, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt. Electronic address: gomaa@ju.edu.sa., Ahmed SS; Department of Microbiology and Immunology, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia. Electronic address: ssahmd@qu.edu.sa., Taha HH; Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah 51452, Saudi Arabia. Electronic address: hag.ahmed@qu.edu.sa., Khalifa AK; Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Cairo 11562, Egypt; Department of Medical Pharmacology, Faculty of Medicine, Nahda University, New Beni Suef 62521, Egypt. Electronic address: amirakaramkhalifa@cu.edu.eg.

Publikováno v: Life sciences [Life Sci] 2024 Oct 01; Vol. 354, pp. 122966. Date of Electronic Publication: 2024 Aug 13.