Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Alibhai, James"'
Autor:
Alibhai, James David
Chronic neurodegenerative diseases, such as Alzheimer’s disease, prion diseases and many others are unified by the aberrant folding of a host encoded protein to a disease-associated isoform and the predictable cell-to-cell spread of disease-associa
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685776
Publikováno v:
Prion
Alibhai, J, Diack, A & Manson, J 2017, ' Disease-associated protein seeding suggests a dissociation between misfolded protein accumulation and neurodegeneration in prion disease ', Prion, vol. 11, no. 6, pp. 381-387 . https://doi.org/10.1080/19336896.2017.1378289
Alibhai, J, Diack, A & Manson, J 2017, ' Disease-associated protein seeding suggests a dissociation between misfolded protein accumulation and neurodegeneration in prion disease ', Prion, vol. 11, no. 6, pp. 381-387 . https://doi.org/10.1080/19336896.2017.1378289
Chronic neurodegenerative diseases, such as prion diseases or Alzheimer's disease, are associated with progressive accumulation of host proteins which misfold and aggregate. Neurodegeneration is restricted to specific neuronal populations which show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::25607093b765277d6d884724f522f2c9
http://europepmc.org/articles/PMC5786362
http://europepmc.org/articles/PMC5786362
Autor:
Alibhai, James1, Blanco, Richard A.1, Barria, Marcelo A.2, Piccardo, Pedro1, Caughey, Byron3, Perry, V. Hugh4, Freeman, Tom C.1, Manson, Jean C.1 jean.manson@roslin.ed.ac.uk
Publikováno v:
PLoS Biology. 11/23/2016, Vol. 14 Issue 11, p1-25. 25p. 3 Color Photographs, 1 Diagram, 4 Graphs.
Autor:
Diack, Abigail B.1 abigail.diack@roslin.ed.ac.uk, Alibhai, James D.2 james.alibhai@ed.ac.uk, Barron, Rona1 rona.barron@roslin.ed.ac.uk, Bradford, Barry1 barry.bradford@roslin.ed.ac.uk, Piccardo, Pedro1 pedro.piccardo@roslin.ed.ac.uk, Manson, Jean C.1 jean.manson@roslin.ed.ac.uk
Publikováno v:
International Journal of Molecular Sciences. 2016, Vol. 17 Issue 1, p82. 18p. 2 Color Photographs, 1 Black and White Photograph.
Publikováno v:
In Handbook of Clinical Neurology 2018 153:85-107
Publikováno v:
Alibhai, J, Diack, A & Manson, J 2018, ' Unravelling the glial response in the pathogenesis of Alzheimer's Disease ', The FASEB Journal, vol. 32, no. 11, pp. 5766-5777 . https://doi.org/10.1096/fj.201801360R
Alzheimer's disease is a progressive, incurable neurodegenerative disease targeting specific neuronal populations within the brain whilst neighbouring neurons appear unaffected. The focus for defining mechanisms has therefore been on the pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3094::bc409afad2ac63a67eb7c02987cd18e1
https://www.pure.ed.ac.uk/ws/files/77053636/fj.201801360r.pdf
https://www.pure.ed.ac.uk/ws/files/77053636/fj.201801360r.pdf
Publikováno v:
In Progress in Molecular Biology and Translational Science 2017 150:157-179
Autor:
Krejciova, Zuzana, Alibhai, James, Zhao, Chen, Krencik, Robert, Rzechorzek, Nina M., Ullian, Erik M, Manson, Jean, Ironside, James W, Head, Mark W, Chandran, Siddharthan
Publikováno v:
Krejciova, Z, Alibhai, J, Zhao, C, Krencik, R, Rzechorzek, N M, Ullian, E M, Manson, J, Ironside, J W, Head, M W & Chandran, S 2017, ' Human stem cell–derived astrocytes replicate human prions in a PRNP genotype–dependent manner ', Journal of Experimental Medicine, vol. 214, no. 12, pp. 3481-3495 . https://doi.org/10.1084/jem.20161547
Prions are infectious agents that cause neurodegenerative diseases such as Creutzfeldt–Jakob disease (CJD). The absence of a human cell culture model that replicates human prions has hampered prion disease research for decades. In this paper, we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3094::6635665afcb6b71d5cdb7e6be24a5986
https://hdl.handle.net/20.500.11820/078759ce-2f46-4e5c-a73a-650bbe1a52f2
https://hdl.handle.net/20.500.11820/078759ce-2f46-4e5c-a73a-650bbe1a52f2
Publikováno v:
Diack, A B, Alibhai, J D & Manson, J C 2017, ' Gene Targeted Transgenic Mouse Models in Prion Research ', Progress in molecular biology and translational science, vol. 150, pp. 157-179 . https://doi.org/10.1016/bs.pmbts.2017.06.008
The production of transgenic mice expressing different forms of the prion protein (PrP) or devoid of PrP has enabled researchers to study the role of PrP in the infectious process of a prion disease and its normal function in the healthy individual.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3094::8902b8c0a39873090165bc2401002797
https://hdl.handle.net/20.500.11820/c5918942-0d86-4e6d-9b19-51c218f9dfd8
https://hdl.handle.net/20.500.11820/c5918942-0d86-4e6d-9b19-51c218f9dfd8