Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Aliaksei Shymanets"'
Autor:
Thorsten Brink, Veronika Leiss, Peter Siegert, Doris Jehle, Julia K Ebner, Carsten Schwan, Aliaksei Shymanets, Sebastian Wiese, Bernd Nürnberg, Michael Hensel, Klaus Aktories, Joachim H C Orth
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007248 (2018)
Salmonella enterica serotype Typhimurium (S. Typhimurium) is one of the most frequent causes of food-borne illness in humans and usually associated with acute self-limiting gastroenteritis. However, in immunocompromised patients, the pathogen can dis
Externí odkaz:
https://doaj.org/article/be888ebac94945eb9cad16e0415b180b
Autor:
Si-Cai Zhang, Lothar Gremer, Henrike Heise, Petra Janning, Aliaksei Shymanets, Ion C Cirstea, Eberhard Krause, Bernd Nürnberg, Mohammad Reza Ahmadian
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102425 (2014)
Small Rho GTPases are well known to regulate a variety of cellular processes by acting as molecular switches. The regulatory function of Rho GTPases is critically dependent on their posttranslational modification at the carboxyl terminus by isoprenyl
Externí odkaz:
https://doaj.org/article/fcd4875f56614d2eabdbcf0693029d43
Autor:
Hashem A Dbouk, Bassem D Khalil, Haiyan Wu, Aliaksei Shymanets, Bernd Nürnberg, Jonathan M Backer
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63833 (2013)
The PI3-kinase pathway is commonly activated in tumors, most often by loss of PTEN lipid phosphatase activity or the amplification or mutation of p110α. Oncogenic mutants have commonly been found in p110α, but rarely in any of the other catalytic s
Externí odkaz:
https://doaj.org/article/36bc4f447e434b27af60f34ee2a64750
Autor:
Gilbert Salloum, Anne R. Bresnick, Nili Greenberg, Aliaksei Shymanets, Samantha D. Heitz, David J. Hamelin, Jack U. Flanagan, Jonathan M. Backer, Elizabeth A. Steidle, Bassem D. Khalil, Zahra Erami, Bernd Nürnberg, Grace Qun Gong, Reece M. Hoffmann, John E. Burke
Phosphoinositide 3-kinase β (PI3Kβ) is regulated by receptor tyrosine kinases (RTKs), G protein–coupled receptors (GPCRs), and small GTPases such as Rac1 and Rab5. Our lab previously identified two residues (Gln(596) and Ile(597)) in the helical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47246c88179024103e52ae35de5a6e4
https://europepmc.org/articles/PMC6433078/
https://europepmc.org/articles/PMC6433078/
Autor:
Emilio Hirsch, Aliaksei Shymanets, Yu Huang, D. Tsvetkov, Bernd Nürnberg, Roland P. Piekorz, Sandra Beer-Hammer, C Harteneck, Kirsten Bucher, Maik Gollasch
Publikováno v:
Biochemistry (Moscow). 81:691-699
The intracellular PI3K-AKT-mTOR pathway is involved in regulation of numerous important cell processes including cell growth, differentiation, and metabolism. The PI3Kα isoform has received particular attention as a novel molecular target in gene th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73675f0c466fa37349ea6f6a2f493a9d
https://doi.org/10.1134/s0006297916070051
https://doi.org/10.1134/s0006297916070051
Autor:
John M. Asara, Barry Honig, Cindy Hodakoski, Douglas Barrows, Anthony D. Couvillon, Aliaksei Shymanets, Ramon Parsons, Bernd Nürnberg, Sarah M. Schoenfeld, Antonina Silkov
Publikováno v:
Journal of Biological Chemistry. 290:28915-28931
Phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase, facilitating the exchange of GDP for GTP on Rac1. GTP-bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0abaccaa1ef996479ae4b7eceda2c71
https://doi.org/10.1074/jbc.m115.668244
https://doi.org/10.1074/jbc.m115.668244
Autor:
Bernd Nürnberg, Yanhua Yao, Bassem D. Khalil, Jaclyn LoPiccolo, Aliaksei Shymanets, Anne R. Bresnick, Zahra Erami, Jonathan M. Backer, Gilbert Salloum
Phosphoinositide 3-kinases (PI 3-kinases) are regulated by a diverse range of upstream activators, including receptor tyrosine kinases (RTKs), G-protein-coupled receptors (GPCRs), and small GTPases from the Ras, Rho and Rab families. For the Class IA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0428f2494a8410be37185f139cb7b452
https://europepmc.org/articles/PMC5858185/
https://europepmc.org/articles/PMC5858185/
Autor:
Thomas E. Exner, Iounut Onila, Christian Harteneck, Christa E. Müller, Philip Lottmann, Kai Fredriksson, Christian Griesinger, Sonja Hinz, Aliaksei Shymanets
Publikováno v:
Angewandte Chemie International Edition
G-protein-coupled-receptors (GPCRs) are of fundamental importance for signal transduction through cell membranes. This makes them important drug targets, but structure-based drug design (SBDD) is still hampered by the limitations for structure determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57efcfcb097647c4b949c8794ea7dd9d
https://hdl.handle.net/11858/00-001M-0000-002D-4113-411858/00-001M-0000-002D-3026-E11858/00-001M-0000-002D-4114-2
https://hdl.handle.net/11858/00-001M-0000-002D-4113-411858/00-001M-0000-002D-3026-E11858/00-001M-0000-002D-4114-2
Autor:
Sandra Beer-Hammer, Aliaksei Shymanets, Prajwal, Bernd Nürnberg, Christian Harteneck, Kirsten Bucher
Publikováno v:
Journal of Biological Chemistry. 288:31059-31068
Class IB phosphoinositide 3-kinase γ (PI3Kγ) comprises a single catalytic p110γ subunit, which binds to two non-catalytic subunits, p87 or p101, and controls a plethora of fundamental cellular responses. The non-catalytic subunits are assumed to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a7f661dd0f8a49d2a687fe20c61068
https://doi.org/10.1074/jbc.m113.508234
https://doi.org/10.1074/jbc.m113.508234
Autor:
Aliaksei Shymanets, Christian Harteneck, Bernd Nürnberg, Reinhard Wetzker, Katja T. Kössmeier, Mohammad Reza Ahmadian
Publikováno v:
Biochemical Journal. 441:851-858
G-protein-regulated PI3Kγ (phosphoinositide 3-kinase γ) plays a crucial role in inflammatory and allergic processes. PI3Kγ, a dimeric protein formed by the non-catalytic p101 and catalytic p110γ subunits, is stimulated by receptor-released Gβγ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15920f13d1f4c9d5e5d4750c7fe035a
https://doi.org/10.1042/bj20111664
https://doi.org/10.1042/bj20111664