Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aliakbar Khalili Yazdi"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract The 5′-mRNA-cap formation is a conserved process in protection of mRNA in eukaryotic cells, resulting in mRNA stability and efficient translation. In humans, two methyltransferases, RNA cap guanine-N7 methyltransferase (hRNMT) and cap-spec
Externí odkaz:
https://doaj.org/article/f2a59a48a16a44dd9a3e57e9add01eed
Autor:
Dominic D.G Owens, Matthew E.R Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Martin P. Schwalm, Raquel A.C Machado, Nicolas Bauer, Xu Wang, Magdalena M. Szewczyk, Cheng Dong, Aiping Dong, Peter Loppnau, Matthew F. Calabrese, Matthew S. Dowling, Jisun Lee, Justin I. Montgomery, Thomas N. O’Connell, Chakrapani Subramanyam, Feng Wang, Matthieu Schapira, Stefan Knapp, Masoud Vedadi, Jinrong Min, Gilles A. Lajoie, Dalia Barsyte-Lovejoy, Dafydd R. Owen, Caroline Schild-Poulter, Cheryl H. Arrowsmith
The CTLH complex is a multi-subunit ubiquitin ligase complex that recognizes substrates with Pro/N-degrons via the substrate receptor GID4. Recently, focus has turned to this complex as a potential mediator of targeted protein degradation, but the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::756b8bd8412abe2d17623cbc6ce6d79d
https://doi.org/10.1101/2023.01.17.524225
https://doi.org/10.1101/2023.01.17.524225
Autor:
Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi
Publikováno v:
Nat Chem Biol
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29b52d0f1e30e6d3bd73de3c2a5989b
https://doi.org/10.1038/s41589-021-00898-0
https://doi.org/10.1038/s41589-021-00898-0
Autor:
Peter Loppnau, Minkui Luo, Pegah Ghiabi, Albina Bolotokova, Irene Chau, Fengling Li, Jing Liu, Matthieu Schapira, Karla J. F. Satchell, Sumera Perveen, Ke Wang, Aliakbar Khalili Yazdi, Paul V. Fish, Jian Jin, Peter Brown, Deyao Li, Masoud Vedadi, David Smil, Kanchan Devkota, Taraneh Hajian
Publikováno v:
Slas Discovery
bioRxiv
bioRxiv
The COVID-19 pandemic has clearly brought the healthcare systems world-wide to a breaking point along with devastating socioeconomic consequences. The SARS-CoV-2 virus which causes the disease uses RNA capping to evade the human immune system. Non-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55059fd32681033cafc1474270f7838
http://europepmc.org/articles/PMC8458670
http://europepmc.org/articles/PMC8458670
Autor:
Aliakbar Khalili Yazdi, Paknoosh Pakarian, Sumera Perveen, Taraneh Hajian, Vijayaratnam Santhakumar, Albina Bolotokova, Fengling Li, Masoud Vedadi
Publikováno v:
ACS infectious diseases. 8(8)
SARS-CoV-2 non-structural protein 13 (nsp13) is a highly conserved helicase and RNA 5'-triphosphatase. It uses the energy derived from the hydrolysis of nucleoside triphosphates for directional movement along the nucleic acids and promotes the unwind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb71ddc35b33be23cdc9be8fd08051a3
https://pubmed.ncbi.nlm.nih.gov/35822715
https://pubmed.ncbi.nlm.nih.gov/35822715
Autor:
Martin Klima, Aliakbar Khalili Yazdi, Fengling Li, Irene Chau, Taraneh Hajian, Albina Bolotokova, H. Ümit Kaniskan, Yulin Han, Ke Wang, Deyao Li, Minkui Luo, Jian Jin, Evzen Boura, Masoud Vedadi
Publikováno v:
Protein science : a publication of the Protein Society. 31(9)
SARS-CoV-2 nsp10-nsp16 complex is a 2'-O-methyltransferase (MTase) involved in viral RNA capping, enabling the virus to evade the immune system in humans. It has been considered a valuable target in the discovery of antiviral therapeutics, as the RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaae3fa1c77c290935cd178f0207afc6
https://pubmed.ncbi.nlm.nih.gov/36040262
https://pubmed.ncbi.nlm.nih.gov/36040262
Autor:
Masoud Vedadi, Pegah Ghiabi, Sumera Perveen, Kanchan Devkota, Fengling Li, Aliakbar Khalili Yazdi, Albina Bolotokova, Taraneh Hajian
Publikováno v:
Slas Discovery
Frequent outbreaks of novel coronaviruses (CoVs), highlighted by the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, necessitate the development of therapeutics that could be easily and effectively administered worldwid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2410bc0c6949f8d83d29fd205ab244f
http://europepmc.org/articles/PMC8216315
http://europepmc.org/articles/PMC8216315
Autor:
Fengling Li, Pegah Ghiabi, Taraneh Hajian, Martin Klima, Alice Shi Ming Li, Aliakbar Khalili Yazdi, Irene Chau, Peter Loppnau, Maria Kutera, Almagul Seitova, Albina Bolotokova, Ashley Hutchinson, Sumera Perveen, Evzen Boura, Masoud Vedadi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1867:130319
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::155268939d5a7ee4c9d6f14f538baaea
https://doi.org/10.1016/j.bbagen.2023.130319
https://doi.org/10.1016/j.bbagen.2023.130319
Autor:
Masoud Vedadi, Aliakbar Khalili Yazdi, Sumera Perveen, Taraneh Hajian, Pegah Ghiabi, Fengling Li, Kanchan Devkota, Peter Loppnau, Albina Bolotokova
Publikováno v:
Slas Discovery
SARS-CoV-2, the coronavirus that causes COVID-19, evades the human immune system by capping its RNA. This process protects the viral RNA and is essential for its replication. Multiple viral proteins are involved in this RNA capping process, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5b5b327560c38c66fa9ae761cb6def
http://europepmc.org/articles/PMC7803792
http://europepmc.org/articles/PMC7803792
Autor:
Sumera Perveen, Aliakbar Khalili Yazdi, Devkota, Kanchan, Fengling Li, Ghiabi, Pegah, Taraneh Hajian, Loppnau, Peter, Bolotokova, Albina, Vedadi, Masoud
Supplemental material, sj-pdf-1-jbx-10.1177_2472555220985040 for A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19 by Sumera Perveen, Aliakbar Khalili Yazdi, Kanchan Devk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223ca589cc038057c3b2d35a0b006f2b