Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Aliaa Abdelrahman"'
Autor:
Christa E. Müller, Aliaa Abdelrahman, Solenne Rivière, Carina Lemke, Dirk Menche, Michael Gütschow, Christin Vielmuth, Christiane Ennenbach
Publikováno v:
Chemmedchem
The archazolids are potent antiproliferative compounds that have recently emerged as a novel class of promising anticancer agents. Their complex macrolide structures and scarce natural supply make the development of more readily available analogues h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7988f2b0f1c0ef9c098d4a9ff0ea00b6
http://europepmc.org/articles/PMC7496434
http://europepmc.org/articles/PMC7496434
Autor:
Sabrina Densborn, Sonja Hinz, Ralf Schmid, Aliaa Abdelrahman, Claudia Spanier, Christa E. Müller, Younis Baqi, Djamil Azazna, Eduardo Fuentes, Maoqun Tian
Publikováno v:
Journal of Medicinal Chemistry. 63:6164-6178
Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dfd5a60d260af345c15b2d83e98659
https://doi.org/10.1021/acs.jmedchem.0c00435
https://doi.org/10.1021/acs.jmedchem.0c00435
Autor:
Sanjay Bhattarai, Norbert Sträter, Georg Rolshoven, Riham M. Idris, Herbert Zimmermann, Marianne Freundlieb, Aliaa Abdelrahman, Sang-Yong Lee, Christian Renn, Jan Pippel, Emma Scaletti, Christa E. Müller, Ali El-Tayeb
Publikováno v:
Journal of Medicinal Chemistry. 63:2941-2957
CD73 inhibitors are promising drugs for the (immuno)therapy of cancer. Here, we present the synthesis, structure-activity relationships, and cocrystal structures of novel derivatives of the competitive CD73 inhibitor α,β-methylene-ADP (AOPCP) subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff664fdb753878f65638b76d65c05265
https://doi.org/10.1021/acs.jmedchem.9b01611
https://doi.org/10.1021/acs.jmedchem.9b01611
Autor:
Raphael Reher, Michael Gütschow, Gabriele M. König, Jim Küppers, Bernd K. Fleischmann, Vigneshwaran Namasivayam, Markus Kuschak, Asuka Inoue, Daniela Wenzel, Christa E. Müller, Aliaa Abdelrahman, Michaela Matthey, Alexander Pfeifer, Sonja Hinz, Jaspal Garg, Stefan Kehraus, Katharina Sylvester, Jan H. Voss, Jonathan G. Schlegel, Muhammad Rafehi
Publikováno v:
British Journal of Pharmacology
Background and purpose G proteins are intracellular switches that transduce and amplify extracellular signals from GPCRs. The Gq protein subtypes, which are coupled to PLC activation, can act as oncogenes, and their expression was reported to be up-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972632909116a4047b4e40a57cd3895d
http://europepmc.org/articles/PMC7070167
http://europepmc.org/articles/PMC7070167
Autor:
Stephanie Weinhausen, Jessica Nagel, Vigneshwaran Namasivayam, Claudia Spanier, Aliaa Abdelrahman, Theodor Hanck, Ralf Hausmann, Christa E. Müller
Publikováno v:
SSRN Electronic Journal.
P2X receptors are ATP-gated ion channels which play a role in many pathophysiological conditions. They are considered as novel drug targets, particularly in the fields of pain, (neuro) inflammation, and cancer. Due to difficulties in developing drug-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1470d27f264b302e3851c50847dc8db
https://doi.org/10.2139/ssrn.4181415
https://doi.org/10.2139/ssrn.4181415
Autor:
Marjorie A. Carnero Corrales, Aliaa Abdelrahman, Yao-Wen Wu, Luca Laraia, Herbert Waldmann, Christa E. Müller, Sarah Zinken, Petra Janning, Muhammad Rafehi, Georgios Konstantinidis
Publikováno v:
Cell Chemical Biology
Carnero Corrales, M A, Zinken, S, Konstantinidis, G, Rafehi, M, Abdelrahman, A, Wu, Y-W, Janning, P, Müller, C E, Laraia, L & Waldmann, H 2021, ' Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin ', Cell Chemical Biology, vol. 28, no. 12, pp. 1750-1757 . https://doi.org/10.1016/j.chembiol.2021.02.017
Carnero Corrales, M A, Zinken, S, Konstantinidis, G, Rafehi, M, Abdelrahman, A, Wu, Y-W, Janning, P, Müller, C E, Laraia, L & Waldmann, H 2021, ' Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin ', Cell Chemical Biology, vol. 28, no. 12, pp. 1750-1757 . https://doi.org/10.1016/j.chembiol.2021.02.017
Signaling pathways are frequently activated through signal-receiving membrane proteins, and the discovery of small molecules targeting these receptors may yield insights into their biology. However, due to their intrinsic properties, membrane protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1601e5df05cc170862fb2b77c73079dd
Autor:
Helmut Wieczorek, Felix Tiburcy, Anna-Christina Schulz-Fincke, Meryem Köse, Johal Ruiz, Stephan Scheeff, Christa E. Müller, Dirk Menche, Michael Gütschow, Solenne Rivière, Aliaa Abdelrahman
Publikováno v:
Journal of medicinal chemistry. 63(4)
Vacuolar type ATPase (V-ATPase) has recently emerged as a promising novel anticancer target based on extensive in vitro and in vivo studies with archazolids, complex polyketide macrolides, which present the most potent V-ATPase inhibitors known to da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5a6118fbe71b40ede0344def29dfc7
https://pubmed.ncbi.nlm.nih.gov/31990540
https://pubmed.ncbi.nlm.nih.gov/31990540
Autor:
Younis Baqi, Aliaa Abdelrahman, Vigneshwaran Namasivayam, Muhammad Rafehi, Christa E. Müller, Alexander Neumann, Theodor Hanck, Enas M. Malik
Publikováno v:
Journal of Medicinal Chemistry. 60:3020-3038
P2Y4 is a Gq protein-coupled receptor activated by uridine-5′-triphosphate (UTP), which is widely expressed in the body, e.g., in intestine, heart, and brain. No selective P2Y4 receptor antagonist has been described so far. Therefore, we developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b130c5556c6814162e2dd205f463bca7
https://doi.org/10.1021/acs.jmedchem.7b00030
https://doi.org/10.1021/acs.jmedchem.7b00030
Autor:
Vigneshwaran Namasivayam, Michel Gillard, Ali El-Tayeb, Jürgen Bajorath, Meryem Köse, Sonja Hinz, Aliaa Abdelrahman, Maggi Burton, Anke C. Schiedel, Christa E. Müller, Marc Roger De Ryck
Publikováno v:
Biochemical Pharmacology. 125:41-54
Antagonists for ATP-activated P2X4 ion channel receptors are currently in the focus as novel drug targets, in particular for the treatment of neuropathic and inflammatory pain. We stably expressed the human, rat and mouse P2X4 receptors in 1321N1 ast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd42028426aa8505efc9ced0e45cf6a
https://doi.org/10.1016/j.bcp.2016.11.016
https://doi.org/10.1016/j.bcp.2016.11.016
Autor:
Aliaa, Abdelrahman, Swapnil G, Yerande, Vigneshwaran, Namasivayam, Tim A, Klapschinski, Mohamad Wessam, Alnouri, Ali, El-Tayeb, Christa E, Müller
Publikováno v:
European journal of medicinal chemistry. 186
Adenosine acts as a powerful signaling molecule via four distinct G protein-coupled receptors, designated A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb0ae0a1e289bd5dba290ea7fde1f636
https://pubmed.ncbi.nlm.nih.gov/31780082
https://pubmed.ncbi.nlm.nih.gov/31780082