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Autor:
Nabil G. Seidah, Janice Mayne, Fred Elisma, Nicholas J. Denis, Maroun Bou Khalil, Annik Prat, Michel Chrétien, Alia Busuttil, Heather Palmer-Smith, Daniel Figeys, Theodore G. Wright
Publikováno v:
Journal of proteome research. 10(4)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in cholesterol homeostasis, mediating degradation of the liver low-density lipoprotein receptor (LDLR). In fact, gain- and loss-of-function PCSK9 variations in human popula