Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals.

Autor: Joel D A Tyndall, Manya Sabherwal, Alia A Sagatova, Mikhail V Keniya, Jacopo Negroni, Rajni K Wilson, Matthew A Woods, Klaus Tietjen, Brian C Monk

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167485 (2016)

Azole antifungals, known as demethylase inhibitors (DMIs), target sterol 14α-demethylase (CYP51) in the ergosterol biosynthetic pathway of fungal pathogens of both plants and humans. DMIs remain the treatment of choice in crop protection against a w

Externí odkaz: https://doaj.org/article/ecc5305817ae4a19aa6dae4d47d44614

Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery

Autor: Mikhail V. Keniya, Brian C. Monk, Manya Sabherwal, Joel D. A. Tyndall, Rajni K. Wilson, Alia A. Sagatova, Matthew A. Woods

Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are not optimal for immunocompromised patients and individuals with comorbidities. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ffb49ea97e4543c1a09084e4be2874
https://europepmc.org/articles/PMC6201081/

Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase

Autor: Mikhail V. Keniya, Joel D. A. Tyndall, Brian C. Monk, Alia A. Sagatova

Publikováno v: Antimicrobial Agents and Chemotherapy. 62

Fungal infections frequently affect immunodeficient individuals and are estimated to kill 1.35 million people per annum. Azole antifungals target the membrane-bound cytochrome P450 monooxygenase lanosterol 14α-demethylase (CYP51; Erg11p). Mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c67ec9be2488630c78b407ad65ebce
https://doi.org/10.1128/aac.02242-17

Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals

Autor: Matthew A. Woods, Klaus Tietjen, Mikhail V. Keniya, Jacopo Negroni, Brian C. Monk, Manya Sabherwal, Joel D. A. Tyndall, Alia A. Sagatova, Rajni K. Wilson

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167485 (2016)
PLoS ONE

Azole antifungals, known as demethylase inhibitors (DMIs), target sterol 14α-demethylase (CYP51) in the ergosterol biosynthetic pathway of fungal pathogens of both plants and humans. DMIs remain the treatment of choice in crop protection against a w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb78bb10a52c1abe893e5f58337a2086
http://europepmc.org/articles/PMC5132298?pdf=render

The new epoch of structural insights into radical SAM enzymology.

Autor: Lachowicz J; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Lee J; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Sagatova A; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Jew K; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Grove TL; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: tyler.grove@einsteinmed.edu.

Publikováno v: Current opinion in structural biology [Curr Opin Struct Biol] 2023 Dec; Vol. 83, pp. 102720. Date of Electronic Publication: 2023 Oct 18.