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Akademický článek

Poly(2-alkyl-2-oxazoline)s: A polymer platform to sustain the release from tablets with a high drug loading

Autor: Aseel Samaro, Maarten Vergaelen, Martin Purino, Ali Tigrine, Victor R. de la Rosa, Niloofar Moazami Goudarzi, Matthieu N. Boone, Valérie Vanhoorne, Richard Hoogenboom, Chris Vervaet

Publikováno v: Materials Today Bio, Vol 16, Iss , Pp 100414- (2022)

Sustaining the release of highly dosed APIs from a matrix tablet is challenging. To address this challenge, this study evaluated the performance of thermoplastic poly (2-alkyl-2-oxazoline)s (PAOx) as matrix excipient to produce sustained-release tabl

Externí odkaz: https://doaj.org/article/3f95825cf65946ae88e09622ff78bc85

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Akademický článek

Nanofibers with a tunable wettability by electrospinning and physical crosslinking of poly(2-n-propyl-2-oxazoline)

Autor: Ella Schoolaert, Luisa Cossu, Jana Becelaere, Joachim F.R. Van Guyse, Ali Tigrine, Maarten Vergaelen, Richard Hoogenboom, Karen De Clerck

Publikováno v: Materials & Design, Vol 192, Iss , Pp 108747- (2020)

This work shows the design of highly porous membranes with tunable wettability based on poly(2-n-propyl-2-oxazoline) (PnPrOx) nanofibers. Wicking and advanced contact angle experiments demonstrate the high potential for applications requiring specifi

Externí odkaz: https://doaj.org/article/006fcb1868c9463d9bbef5d7d7286ec7

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Akademický článek

Unravelling the Miscibility of Poly(2-oxazoline)s: A Novel Polymer Class for the Formulation of Amorphous Solid Dispersions

Autor: Melissa Everaerts, Ali Tigrine, Victor R. de la Rosa, Richard Hoogenboom, Peter Adriaensens, Christian Clasen, Guy Van den Mooter

Publikováno v: Molecules, Vol 25, Iss 16, p 3587 (2020)

Water-soluble polymers are still the most popular carrier for the preparation of amorphous solid dispersions (ASDs). The advantage of this type of carrier is the fast drug release upon dissolution of the water-soluble polymer and thus the initial hig

Externí odkaz: https://doaj.org/article/385e901c986741a2b1c24fa14f380bae

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Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline)

Autor: Bart Verbraeken, Maarten Vergaelen, Joachim F. R. Van Guyse, Richard Hoogenboom, Ali Tigrine, Bryn D. Monnery, Annelore Podevyn, Victor Retamero De La Rosa

Publikováno v: Green Chemistry. 22:1747-1753

Poly(2-ethyl-2-oxazoline) (PEtOx) is the most common poly(2-oxazoline) for biomedical applications resulting from its high water-solubility, good commercial availability and well-controlled polymerization. In this article, we report the polymerizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42ec2e27caa7b5c059fd77d9b5356927
https://doi.org/10.1039/c9gc03872h

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Correction to 'Judging Enzyme Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks'

Autor: Gadi Slor, Alis R. Olea, Sílvia Pujals, Ali Tigrine, Victor R. De La Rosa, Richard Hoogenboom, Lorenzo Albertazzi, Roey J. Amir

Publikováno v: Biomacromolecules. 23:4957-4957

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e92b3ff45a6875a40439dc185c57588
https://doi.org/10.1021/acs.biomac.2c01107

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Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks

Autor: Alis R. Olea, Lorenzo Albertazzi, Roey J. Amir, Victor Retamero De La Rosa, Silvia Pujals, Richard Hoogenboom, Ali Tigrine, Gadi Slor

Publikováno v: Biomacromolecules, 22(3), 1197-1210. American Chemical Society
Biomacromolecules
BIOMACROMOLECULES

Enzymatically degradable polymeric micelles have great potential as drug delivery systems, allowing the selective release of their active cargo at the site of disease. Furthermore, enzymatic degradation of the polymeric nanocarriers facilitates clear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6d4b6fc7a0a9dda534f57de90aae99
https://research.tue.nl/nl/publications/63a8913c-cd75-440a-9e77-9d92c5e3d854