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Dietary fiber metabolites regulate innate lymphoid cell responses

Autor: Qingyang Liu, Chang H. Kim, Leon Friesen, Ali Sepahi

Publikováno v: Mucosal immunology

Summary Innate lymphoid cells (ILCs) rapidly undergo expansion in population size and functional maturation in response to cytokines that signal infection, tissue damage or changes in physiology. Optimal ILC responses are shaped, in part, by the micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f611cec532b80cb72c7d1ee9bc3fcc57
https://doi.org/10.1038/s41385-020-0312-8

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First-in-Human Phase I/II ICONIC Trial of the ICOS Agonist Vopratelimab Alone and with Nivolumab: ICOS-High CD4 T-Cell Populations and Predictors of Response

Publikováno v: Clin Cancer Res

Purpose: The first-in-human phase I/II ICONIC trial evaluated an investigational inducible costimulator (ICOS) agonist, vopratelimab, alone and in combination with nivolumab in patients with advanced solid tumors. Patients and Methods: In phase I, pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed38ce215255493942ef71d231ae66c
https://pubmed.ncbi.nlm.nih.gov/35792807

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Long-term efficacy of nasal vaccination against enteric red mouth (ERM) disease and infectious hematopoietic necrosis (IHN) in juvenile rainbow trout (Oncorhynchus mykiss)

Autor: Jie Ma, Elisa Casadei, Timothy J. Bruce, Ali Sepahi, Kenneth D. Cain, Irene Salinas

Publikováno v: Vaccine. 40(2)

Previous research demonstrated that bacterial and viral vaccines delivered via the nasal route in rainbow trout (Oncorhynchus mykiss) at 7 and 28 days post-vaccination are highly protective (95% protection). Long-term protection following nasal vacci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c884fb3be4e9be081f27183575c13cb
https://pubmed.ncbi.nlm.nih.gov/34893343

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Symbiont-derived sphingolipids regulate inflammatory responses in rainbow trout (Oncorhynchus mykiss)

Autor: Mariah Sanchez, Ali Sepahi, Irene Salinas, Elisa Casadei

Publikováno v: Aquaculture. 495:932-939

Farmed fish live in association with diverse bacterial communities that produce wide arrays of metabolites. In rainbow trout, the skin and the gills are colonized by Flectobacillus major, a bacterium known to produce sphingolipids (SLs). The goal of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd925a2059273ced3efd03397650fc0
https://doi.org/10.1016/j.aquaculture.2018.05.051

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CK12a, a CCL19-like Chemokine That Orchestrates both Nasal and Systemic Antiviral Immune Responses in Rainbow Trout

Autor: Fumio Takizawa, Scott E. LaPatra, Irene Salinas, Ali Sepahi, Luca Tacchi, Elisa Casadei

Publikováno v: The Journal of Immunology. 199:3900-3913

Chemokines and chemokine receptors have rapidly diversified in teleost fish but their immune functions remain unclear. We report in this study that CCL19, a chemokine known to control lymphocyte migration and compartmentalization of lymphoid tissues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de372ed755a2e0601ba635c61dce5ea
https://doi.org/10.4049/jimmunol.1700757

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Olfactory sensory neurons mediate ultrarapid antiviral immune responses in a TrkA-dependent manner

Autor: Christopher A. Johnston, Mar Huertas, Victoriano Mulero, Jorge Galindo-Villegas, Aurora Kraus, Irene Salinas, Elisa Casadei, Ali Sepahi, Pilar Muñoz, Diana García-Moreno, Cecelia Kelly

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 116(25)

The nervous system regulates host immunity in complex ways. Vertebrate olfactory sensory neurons (OSNs) are located in direct contact with pathogens; however, OSNs’ ability to detect danger and initiate immune responses is unclear. We report that n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510b46dbeb7bf119a4981d426939486f
https://pubmed.ncbi.nlm.nih.gov/31160464

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Olfactory sensory neurons mediate ultra-rapid antiviral immune responses in teleosts in a TrkA-dependent manner

Autor: Cecelia Kelly, Ali Sepahi, Diana García-Moreno, Mulero, Aurora Kraus, Mar Huertas, Irene Salinas, Pilar Muñoz, Christopher A. Johnston, Jorge Galindo-Villegas

SummaryThe nervous system is known to regulate host immune responses. However, the ability of neurons to detect danger and initiate immune responses at barrier tissues is unclear. Vertebrate olfactory sensory neurons (OSNs) are located in direct cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000abd4acbe97fe7b208073819c98c5b

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Rainbow trout as a model for the study of neuroimmune interactions in the nasal mucosa

Autor: Irene Salinas, Ali Sepahi, Aurora Kraus, Pankoj Das

Publikováno v: The Journal of Immunology. 202:73.5-73.5

Many pathogens exploit the olfactory route to infect the lower respiratory tract or the central nervous system. Understanding the mechanisms by which the nasal mucosa halts pathogen progression is vital for the control of many human diseases. We have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d25d04e796b3126c48c859e53105b4e4
https://doi.org/10.4049/jimmunol.202.supp.73.5

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