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Akademický článek

Identification and targeting of selective vulnerability rendered by tamoxifen resistance

Autor: Madhurendra Singh, Xiaolei Zhou, Xinsong Chen, Gema Sanz Santos, Sylvain Peuget, Qing Cheng, Ali Rihani, Elias S. J. Arnér, Johan Hartman, Galina Selivanova

Publikováno v: Breast Cancer Research, Vol 22, Iss 1, Pp 1-16 (2020)

Abstract Background The estrogen receptor (ER)-positive breast cancer represents over 80% of all breast cancer cases. Even though adjuvant hormone therapy with tamoxifen (TMX) is saving lives of patients with ER-positive breast cancer, the acquired r

Externí odkaz: https://doaj.org/article/f5121b8f3c484ea1840e8f42cfd9a407

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Akademický článek

Expressed repeat elements improve RT-qPCR normalization across a wide range of zebrafish gene expression studies.

Autor: Suzanne Vanhauwaert, Gert Van Peer, Ali Rihani, Els Janssens, Pieter Rondou, Steve Lefever, Anne De Paepe, Paul J Coucke, Frank Speleman, Jo Vandesompele, Andy Willaert

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109091 (2014)

The selection and validation of stably expressed reference genes is a critical issue for proper RT-qPCR data normalization. In zebrafish expression studies, many commonly used reference genes are not generally applicable given their variability in ex

Externí odkaz: https://doaj.org/article/a6382c55a7bf4b94ac25bc9646255510

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Akademický článek

CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients.

Autor: Ali Rihani, Bram De Wilde, Fjoralba Zeka, Geneviève Laureys, Nadine Francotte, Gian Paolo Tonini, Simona Coco, Rogier Versteeg, Rosa Noguera, Johannes H Schulte, Angelika Eggert, Raymond L Stallings, Frank Speleman, Jo Vandesompele, Tom Van Maerken

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114696 (2014)

BACKGROUND:Neuroblastoma is a pediatric cancer that exhibits a wide clinical spectrum ranging from spontaneous regression in low-risk patients to fatal disease in high-risk patients. The identification of single nucleotide polymorphisms (SNPs) may he

Externí odkaz: https://doaj.org/article/641bb4ff30014f52b5b4b937801eff16

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Akademický článek

Effective Alu repeat based RT-Qpcr normalization in cancer cell perturbation experiments.

Autor: Ali Rihani, Tom Van Maerken, Filip Pattyn, Gert Van Peer, Anneleen Beckers, Sara De Brouwer, Candy Kumps, Evelien Mets, Joni Van der Meulen, Pieter Rondou, Carina Leonelli, Pieter Mestdagh, Frank Speleman, Jo Vandesompele

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71776 (2013)

BACKGROUND: Measuring messenger RNA (mRNA) levels using the reverse transcription quantitative polymerase chain reaction (RT-qPCR) is common practice in many laboratories. A specific set of mRNAs as internal control reference genes is considered as t

Externí odkaz: https://doaj.org/article/bb6c9114c6fd4232a701296f6f2866ff

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