Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Ali Rana Atilgan"'
Autor:
Isik Kantarcioglu, Ilona K. Gaszek, Tandac F. Guclu, M. Sadik Yildiz, Ali Rana Atilgan, Erdal Toprak, Canan Atilgan
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Efflux-mediated β-lactam resistance is a major public health concern, reducing the effectiveness of β-lactam antibiotics against many bacteria. Structural analyses show the efflux protein TolC in Gram-negative bacteria acts as a channel fo
Externí odkaz:
https://doaj.org/article/71075e17eac44e9d81e5283f7576a9b9
Autor:
Madhu Sudan Manna, Yusuf Talha Tamer, Ilona Gaszek, Nicole Poulides, Ayesha Ahmed, Xiaoyu Wang, Furkan C. R. Toprak, DaNae R. Woodard, Andrew Y. Koh, Noelle S. Williams, Dominika Borek, Ali Rana Atilgan, John D. Hulleman, Canan Atilgan, Uttam Tambar, Erdal Toprak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The efficacy of the antibiotic trimethoprim, which inhibits bacterial dihydrofolate reductase (DHFR), is limited by the rapid emergence of resistant bacteria. Here, Manna et al. show that 4’-desmethyltrimethoprim inhibits DHFR and a common TMP-resi
Externí odkaz:
https://doaj.org/article/0c5515c73c4846e48b35aa04d428f118
Autor:
Melih Papila, Ali Rana Atilgan
Publikováno v:
Forces in Mechanics, Vol 6, Iss , Pp 100066- (2022)
Composite-walled hexagonal honeycomb core is considered for stiffness-based design. It is shown that the torsional and flexural stiffnesses of its all-composite sandwich may be 3- and 8-times higher, respectively, compared to structural foam core san
Externí odkaz:
https://doaj.org/article/2b947e39d5e94bcaacff59c06bafba4d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
We address the problem of triggering dissociation events between proteins that have formed a complex. We have collected a set of 25 non-redundant, functionally diverse protein complexes having high-resolution three-dimensional structures in both the
Externí odkaz:
https://doaj.org/article/8fea60f5320749289b8674b35937b9d3
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 12, p e1003366 (2013)
We elucidate the mechanisms that lead to population shifts in the conformational states of calcium-loaded calmodulin (Ca(2+)-CaM). We design extensive molecular dynamics simulations to classify the effects that are responsible for adopting occupied c
Externí odkaz:
https://doaj.org/article/4cd037c83b854e2badcf1dcf6f9a172a
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15551 (2010)
BackgroundIn recent years, there is aroused interest in expressing complex systems as networks of interacting nodes. Using descriptors from graph theory, it has been possible to classify many diverse systems derived from social and physical sciences
Externí odkaz:
https://doaj.org/article/c52411f91b014eb7900e73c62359bbd8
Autor:
Canan Atilgan, Ali Rana Atilgan
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 10, p e1000544 (2009)
We study apo and holo forms of the bacterial ferric binding protein (FBP) which exhibits the so-called ferric transport dilemma: it uptakes iron from the host with remarkable affinity, yet releases it with ease in the cytoplasm for subsequent use. Th
Externí odkaz:
https://doaj.org/article/89afbcf78f7f4c6a93c39c80c15187dd
Publikováno v:
Journal of Chemical Information and Modeling. 62:6715-6726
Antibiotic resistance is a global health problem in which mutations occurring in functional proteins render drugs ineffective. The working mechanisms of the arising mutants are seldom apparent; a methodology to decipher these mechanisms systematicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea16ab6b5fcdc2d407033ae0f4a69e2
https://doi.org/10.1021/acs.jcim.2c00507
https://doi.org/10.1021/acs.jcim.2c00507
Autor:
Canan Atilgan, Goksin Liu, Farzaneh Jalalypour, Erhan Ekmen, Melike Berksoz, Ali Rana Atilgan, Zehra Sayers
Publikováno v:
Biophysical Journal. 122:444a-445a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d174dd9075be414347ccfc49b3ff7e68
https://doi.org/10.1016/j.bpj.2022.11.2399
https://doi.org/10.1016/j.bpj.2022.11.2399
Publikováno v:
The Journal of Physical Chemistry B. 125:2266-2276
The third domain of PSD-95 (PDZ3) is a model for investigating allosteric communication in protein and ligand interactions. While motifs contributing to its binding specificity have been scrutinized, a conformational dynamical basis is yet to be esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94d510771df51d35937e260c11cedd8
https://doi.org/10.1021/acs.jpcb.0c11604
https://doi.org/10.1021/acs.jpcb.0c11604