Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Ali Rana Atilgan"'
Autor:
Isik Kantarcioglu, Ilona K. Gaszek, Tandac F. Guclu, M. Sadik Yildiz, Ali Rana Atilgan, Erdal Toprak, Canan Atilgan
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Efflux-mediated β-lactam resistance is a major public health concern, reducing the effectiveness of β-lactam antibiotics against many bacteria. Structural analyses show the efflux protein TolC in Gram-negative bacteria acts as a channel fo
Externí odkaz:
https://doaj.org/article/71075e17eac44e9d81e5283f7576a9b9
Autor:
Madhu Sudan Manna, Yusuf Talha Tamer, Ilona Gaszek, Nicole Poulides, Ayesha Ahmed, Xiaoyu Wang, Furkan C. R. Toprak, DaNae R. Woodard, Andrew Y. Koh, Noelle S. Williams, Dominika Borek, Ali Rana Atilgan, John D. Hulleman, Canan Atilgan, Uttam Tambar, Erdal Toprak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The efficacy of the antibiotic trimethoprim, which inhibits bacterial dihydrofolate reductase (DHFR), is limited by the rapid emergence of resistant bacteria. Here, Manna et al. show that 4’-desmethyltrimethoprim inhibits DHFR and a common TMP-resi
Externí odkaz:
https://doaj.org/article/0c5515c73c4846e48b35aa04d428f118
Autor:
Melih Papila, Ali Rana Atilgan
Publikováno v:
Forces in Mechanics, Vol 6, Iss , Pp 100066- (2022)
Composite-walled hexagonal honeycomb core is considered for stiffness-based design. It is shown that the torsional and flexural stiffnesses of its all-composite sandwich may be 3- and 8-times higher, respectively, compared to structural foam core san
Externí odkaz:
https://doaj.org/article/2b947e39d5e94bcaacff59c06bafba4d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
We address the problem of triggering dissociation events between proteins that have formed a complex. We have collected a set of 25 non-redundant, functionally diverse protein complexes having high-resolution three-dimensional structures in both the
Externí odkaz:
https://doaj.org/article/8fea60f5320749289b8674b35937b9d3
Publikováno v:
Journal of Chemical Information and Modeling. 62:6715-6726
Antibiotic resistance is a global health problem in which mutations occurring in functional proteins render drugs ineffective. The working mechanisms of the arising mutants are seldom apparent; a methodology to decipher these mechanisms systematicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea16ab6b5fcdc2d407033ae0f4a69e2
https://doi.org/10.1021/acs.jcim.2c00507
https://doi.org/10.1021/acs.jcim.2c00507
Autor:
Canan Atilgan, Goksin Liu, Farzaneh Jalalypour, Erhan Ekmen, Melike Berksoz, Ali Rana Atilgan, Zehra Sayers
Publikováno v:
Biophysical Journal. 122:444a-445a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d174dd9075be414347ccfc49b3ff7e68
https://doi.org/10.1016/j.bpj.2022.11.2399
https://doi.org/10.1016/j.bpj.2022.11.2399
Publikováno v:
The Journal of Physical Chemistry B. 125:2266-2276
The third domain of PSD-95 (PDZ3) is a model for investigating allosteric communication in protein and ligand interactions. While motifs contributing to its binding specificity have been scrutinized, a conformational dynamical basis is yet to be esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94d510771df51d35937e260c11cedd8
https://doi.org/10.1021/acs.jpcb.0c11604
https://doi.org/10.1021/acs.jpcb.0c11604
Autor:
Goksin Liu, Erhan Ekmen, Farzaneh Jalalypour, Haydyn D. T. Mertens, Cy M. Jeffries, Dmitri Svergun, Ali Rana Atilgan, Canan Atilgan, Zehra Sayers
Publikováno v:
The journal of chemical physics 158(8), 085101 (2023). doi:10.1063/5.0136558
The journal of chemical physics 158(8), 085101 (2023). doi:10.1063/5.0136558
This study combines molecular dynamics (MD) simulations with small angle x-ray scattering (SAXS) measurements to investigate the range of conformations that can be adop
This study combines molecular dynamics (MD) simulations with small angle x-ray scattering (SAXS) measurements to investigate the range of conformations that can be adop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089c41919da9d0525ad38e76cbc521fd
https://doi.org/10.1063/5.0136558
https://doi.org/10.1063/5.0136558
Publikováno v:
Biophysical Journal. 122:59a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b38f37e9f164b7bffb247f37e8019fdc
https://doi.org/10.1016/j.bpj.2022.11.527
https://doi.org/10.1016/j.bpj.2022.11.527
Publikováno v:
Journal of Complex Networks. 10
A direct way to spot structural features that are universally shared among proteins is to find proper analogues from simpler condensed matter systems. In most cases, sphere-packing arguments provide a straightforward route for structural comparison,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde3c406622236f426c5f23009c2c14f
https://doi.org/10.1093/comnet/cnab048
https://doi.org/10.1093/comnet/cnab048