Výsledky vyhledávání - "Ali Motazedian"

Akademický článek

The use of simultaneous reprogramming and gene correction to generate an osteogenesis imperfecta patient COL1A1 c. 3936 G>T iPSC line and an isogenic control iPSC line

Autor: Sara Howden, Hani Hosseini Far, Ali Motazedian, Andrew G. Elefanty, Edouard G. Stanley, Shireen R. Lamandé, John F. Bateman

Publikováno v: Stem Cell Research, Vol 38, Iss , Pp - (2019)

To develop a disease model for the human ‘brittle bone’ disease, osteogenesis imperfecta, we used a simultaneous reprogramming and CRISPR-Cas9 genome editing method to produce an iPSC line with the heterozygous patient mutation (COL1A1 c. 3936 G>

Externí odkaz: https://doaj.org/article/0d567e03d9414b8b8b904885b2d2730e

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Akademický článek

Generation of a heterozygous COL1A1 (c.3969_3970insT) osteogenesis imperfecta mutation human iPSC line, MCRIi001-A-1, using CRISPR/Cas9 editing

Autor: Hani Hosseini Far, Yudha Nur Patria, Ali Motazedian, Andrew G. Elefanty, Edouard G. Stanley, Shireen R. Lamandé, John F. Bateman

Publikováno v: Stem Cell Research, Vol 37, Iss , Pp - (2019)

To develop a disease model for the human ‘brittle bone’ disease, osteogenesis imperfecta, we have used gene editing to produce a facsimile of the patient heterozygous COL1A1 mutation in an established control iPSC line. The gene-edited line had a

Externí odkaz: https://doaj.org/article/5e21f1734ebc46d6ac699a5b50796a7b

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Akademický článek

GAPTrap: A Simple Expression System for Pluripotent Stem Cells and Their Derivatives

Publikováno v: Stem Cell Reports, Vol 7, Iss 3, Pp 518-526 (2016)

The ability to reliably express fluorescent reporters or other genes of interest is important for using human pluripotent stem cells (hPSCs) as a platform for investigating cell fates and gene function. We describe a simple expression system, designa

Externí odkaz: https://doaj.org/article/84991faa8f614fe795274f0c6fa6e99b

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Akademický článek

An Engineered N-Cadherin Substrate for Differentiation, Survival, and Selection of Pluripotent Stem Cell-Derived Neural Progenitors.

Autor: Amranul Haque, Nihad Adnan, Ali Motazedian, Farhima Akter, Sharif Hossain, Koichi Kutsuzawa, Kakon Nag, Eiry Kobatake, Toshihiro Akaike

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0135170 (2015)

For stem cell-based treatment of neurodegenerative diseases a better understanding of key developmental signaling pathways and robust techniques for producing neurons with highest homogeneity are required. In this study, we demonstrate a method using

Externí odkaz: https://doaj.org/article/c140820deb24400aa2fcec42a6daa3af

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