Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Ali Motazedian"'
1
Akademický článek
Efficient generation of human NOTCH ligand-expressing haemogenic endothelial cells as infrastructure for in vitro haematopoiesis and lymphopoiesis
Autor: Shicheng Sun, Ali Motazedian, Jacky Y. Li, Kevin Wijanarko, Joe Jiang Zhu, Kothila Tharmarajah, Kathleen A. Strumila, Anton Shkaruta, L. Rayburn Nigos, Jacqueline V. Schiesser, Yi Yu, Paul J. Neeson, Elizabeth S. Ng, Andrew G. Elefanty, Edouard G. Stanley
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Arterial endothelial cells (AECs) are the founder cells for intraembryonic haematopoiesis. Here, we report a method for the efficient generation of human haemogenic DLL4+ AECs from pluripotent stem cells (PSC). Time-series single-cell RNA-se
Externí odkaz: https://doaj.org/article/6b789ce0af934d5d87158dc872de5c71
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2
Akademický článek
The use of simultaneous reprogramming and gene correction to generate an osteogenesis imperfecta patient COL1A1 c. 3936 G>T iPSC line and an isogenic control iPSC line
Autor: Sara Howden, Hani Hosseini Far, Ali Motazedian, Andrew G. Elefanty, Edouard G. Stanley, Shireen R. Lamandé, John F. Bateman
Publikováno v: Stem Cell Research, Vol 38, Iss , Pp - (2019)
To develop a disease model for the human ‘brittle bone’ disease, osteogenesis imperfecta, we used a simultaneous reprogramming and CRISPR-Cas9 genome editing method to produce an iPSC line with the heterozygous patient mutation (COL1A1 c. 3936 G>
Externí odkaz: https://doaj.org/article/0d567e03d9414b8b8b904885b2d2730e
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3
Akademický článek
Generation of a heterozygous COL1A1 (c.3969_3970insT) osteogenesis imperfecta mutation human iPSC line, MCRIi001-A-1, using CRISPR/Cas9 editing
Autor: Hani Hosseini Far, Yudha Nur Patria, Ali Motazedian, Andrew G. Elefanty, Edouard G. Stanley, Shireen R. Lamandé, John F. Bateman
Publikováno v: Stem Cell Research, Vol 37, Iss , Pp - (2019)
To develop a disease model for the human ‘brittle bone’ disease, osteogenesis imperfecta, we have used gene editing to produce a facsimile of the patient heterozygous COL1A1 mutation in an established control iPSC line. The gene-edited line had a
Externí odkaz: https://doaj.org/article/5e21f1734ebc46d6ac699a5b50796a7b
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9
Akademický článek
GAPTrap: A Simple Expression System for Pluripotent Stem Cells and Their Derivatives
Autor: Tim Kao, Tanya Labonne, Jonathan C. Niclis, Ritu Chaurasia, Zerina Lokmic, Elizabeth Qian, Freya F. Bruveris, Sara E. Howden, Ali Motazedian, Jacqueline V. Schiesser, Magdaline Costa, Koula Sourris, Elizabeth Ng, David Anderson, Antonietta Giudice, Peter Farlie, Michael Cheung, Shireen R. Lamande, Anthony J. Penington, Clare L. Parish, Lachlan H. Thomson, Arash Rafii, David A. Elliott, Andrew G. Elefanty, Edouard G. Stanley
Publikováno v: Stem Cell Reports, Vol 7, Iss 3, Pp 518-526 (2016)
The ability to reliably express fluorescent reporters or other genes of interest is important for using human pluripotent stem cells (hPSCs) as a platform for investigating cell fates and gene function. We describe a simple expression system, designa
Externí odkaz: https://doaj.org/article/84991faa8f614fe795274f0c6fa6e99b
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