Zobrazeno 1 - 10
of 513
pro vyhledávání: '"Ali Mortazavi"'
Autor:
Nicole D. Schartz, Heidi Y. Liang, Klebea Carvalho, Shu-Hui Chu, Adrian Mendoza-Arvilla, Tiffany J. Petrisko, Angela Gomez-Arboledas, Ali Mortazavi, Andrea J. Tenner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Alzheimer’s disease (AD) is the leading cause of dementia in older adults, and the need for effective, sustainable therapeutic targets is imperative. The complement pathway has been proposed as a therapeutic target. C5aR1 inhibition reduce
Externí odkaz:
https://doaj.org/article/c5d13e6662b4496baed37120ad829da6
Autor:
Ali Mortazavi, Torekeldi Maratov
Publikováno v:
ACS Omega, Vol 9, Iss 30, Pp 32513-32524 (2024)
Externí odkaz:
https://doaj.org/article/ff38a1dab9cb4fb3a448122895063f8e
Autor:
Annabel K. Short, Ryan Weber, Noriko Kamei, Christina Wilcox Thai, Hina Arora, Ali Mortazavi, Hal S. Stern, Laura Glynn, Tallie Z. Baram
Publikováno v:
Neurobiology of Stress, Vol 31, Iss , Pp 100652- (2024)
Adverse early-life experiences (ELA) affect a majority of the world's children. Whereas the enduring impact of ELA on cognitive and emotional health is established, there are no tools to predict vulnerability to ELA consequences in an individual chil
Externí odkaz:
https://doaj.org/article/8c4ddf93e8574d83aedccd298453500f
Autor:
Xiangduo Kong, Nam Viet Nguyen, Yumeng Li, Jasmine Shaaban Sakr, Kate Williams, Sheila Sharifi, Jonathan Chau, Altay Bayrakci, Seiya Mizuno, Satoru Takahashi, Tohru Kiyono, Rabi Tawil, Ali Mortazavi, Kyoko Yokomori
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109357- (2024)
Summary: Facioscapulohumeral dystrophy (FSHD) is linked to contraction of D4Z4 repeats on chromosome 4q with SMCHD1 mutations acting as a disease modifier. D4Z4 heterochromatin disruption and abnormal upregulation of the transcription factor DUX4, en
Externí odkaz:
https://doaj.org/article/f69dcee0cc5f45588408be663a8a6bce
Autor:
Zhiheng Liu, Giovanni Quinones-Valdez, Ting Fu, Elaine Huang, Mudra Choudhury, Fairlie Reese, Ali Mortazavi, Xinshu Xiao
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Although long-read RNA-seq is increasingly applied to characterize full-length transcripts it can also enable detection of nucleotide variants, such as genetic mutations or RNA editing sites, which is significantly under-explored. Here, we p
Externí odkaz:
https://doaj.org/article/cb2b9ccedc6841eebe622d52e83422cf
Autor:
Reza Shahraki Shahdabadi, Ali Mortazavi, Pouria Lotfi, Seyyed Ehsan Shakib, Mohammad Mustafa Ghafurian
Publikováno v:
Case Studies in Thermal Engineering, Vol 52, Iss , Pp 103666- (2023)
In this study, we examined a solar still made of galvanized iron that was exposed to a solar simulator with a light intensity of 904 W/m2. We used iron ore, granite, and sponge as photoabsorbers on the surface of the stairs to enhance the interaction
Externí odkaz:
https://doaj.org/article/d37b0a48d2624172971a485f3cf2db40
Autor:
Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine S. Sakr, Angela Gomez-Arboledas, Miguel A. Arreola, Celia da Cunha, Jimmy Phan, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Jonathan Neumann, Ghassan Filimban, Zechuan Shi, Giedre Milinkeviciute, Dominic I. Javonillo, Katelynn Tran, Magdalena Gantuz, Stefania Forner, Vivek Swarup, Andrea J. Tenner, Frank M. LaFerla, Marcelo A. Wood, Ali Mortazavi, Grant R. MacGregor, Kim N. Green
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-26 (2023)
Abstract Background The TREM2 R47H variant is one of the strongest genetic risk factors for late-onset Alzheimer’s Disease (AD). Unfortunately, many current Trem2 R47H mouse models are associated with cryptic mRNA splicing of the mutant allele that
Externí odkaz:
https://doaj.org/article/7cc752a4e65d4dbe841fd116a51289c8
Autor:
Annabel K. Short, Christina W. Thai, Yuncai Chen, Noriko Kamei, Aidan L. Pham, Matthew T. Birnie, Jessica L. Bolton, Ali Mortazavi, Tallie Z. Baram
Publikováno v:
Biological Psychiatry Global Open Science, Vol 3, Iss 1, Pp 99-109 (2023)
Background: Mental health and vulnerabilities to neuropsychiatric disorders involve the interplay of genes and environment, particularly during sensitive developmental periods. Early-life adversity (ELA) and stress promote vulnerabilities to stress-r
Externí odkaz:
https://doaj.org/article/36084c5dad3d4921b7406a533444ff1b
Autor:
Angela Gomez-Arboledas, Klebea Carvalho, Gabriela Balderrama-Gutierrez, Shu-Hui Chu, Heidi Yahan Liang, Nicole D. Schartz, Purnika Selvan, Tiffany J. Petrisko, Miranda A. Pan, Ali Mortazavi, Andrea J. Tenner
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-21 (2022)
Abstract Multiple studies have recognized the involvement of the complement cascade during Alzheimer’s disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the progression of this neurodegenerative disease is still not clear.
Externí odkaz:
https://doaj.org/article/e8a2e8f8ffde448880a8e769c6b9d008
Autor:
Klebea Carvalho, Nicole D. Schartz, Gabriela Balderrama-Gutierrez, Heidi Y. Liang, Shu-Hui Chu, Purnika Selvan, Angela Gomez-Arboledas, Tiffany J. Petrisko, Maria I. Fonseca, Ali Mortazavi, Andrea J. Tenner
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-21 (2022)
Abstract Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, rec
Externí odkaz:
https://doaj.org/article/d254ddd8a4eb41ccbf2722299212173b