Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Ali Maawy"'
Autor:
Yukihiko Hiroshima, Yong Zhang, Ming Zhao, Nan Zhang, Takashi Murakami, Ali Maawy, Sumiyuki Mii, Fuminari Uehara, Mako Yamamoto, Shinji Miwa, Shuya Yano, Masashi Momiyama, Ryutaro Mori, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Yasushi Ichikawa, Michael Bouvet, Itaru Endo, Robert M Hoffman
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0120358 (2015)
We have previously developed mouse models of HER-2-positive cervical cancer. Tumors in nude mice had histological structures similar to the original tumor and were stained by anti-HER-2 antibody in the same pattern as the patient's cancer. We have al
Externí odkaz:
https://doaj.org/article/18a88f34fb5d41cd84687f9f4224c51e
Autor:
Yukihiko Hiroshima, Yong Zhang, Nan Zhang, Ali Maawy, Sumiyuki Mii, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Takashi Murakami, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Yasushi Ichikawa, Michael Bouvet, Takuya Murata, Itaru Endo, Robert M Hoffman
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117417 (2015)
Squamous cell carcinoma of the cervix, highly prevalent in the developing world, is often metastatic and treatment resistant with no standard treatment protocol. Our laboratory pioneered the patient-derived orthotopic xenograft (PDOX) nude mouse mode
Externí odkaz:
https://doaj.org/article/3a244f243de14625bdd5a15f9e4e2b26
Autor:
Yukihiko Hiroshima, Ming Zhao, Yong Zhang, Nan Zhang, Ali Maawy, Takashi Murakami, Sumiyuki Mii, Fuminari Uehara, Mako Yamamoto, Shinji Miwa, Shuya Yano, Masashi Momiyama, Ryutaro Mori, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Yasushi Ichikawa, Michael Bouvet, Itaru Endo, Robert M Hoffman
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134324 (2015)
A patient-derived nude-mouse model of soft-tissue sarcoma has been established and treated in the following groups: (1) untreated controls; (2) gemcitabine (GEM) (80 mg/kg, ip, weekly, 3 weeks); (3) Pazopanib (100 mg/kg, orally, daily, 3 weeks) and (
Externí odkaz:
https://doaj.org/article/dd380bc9ca204f398e9696971cc6f411
Autor:
Yukihiko Hiroshima, Ali Maawy, Yong Zhang, Sho Sato, Takashi Murakami, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M Hoffman
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99977 (2014)
The aim of this study is to determine if ultraviolet light (UVC) irradiation in combination with fluorescence-guided surgery (FGS) can eradicate metastatic human pancreatic cancer in orthotopic nude-mouse models. Two weeks after orthotopic implantati
Externí odkaz:
https://doaj.org/article/761d9fc4a8474241bdc864877e185e13
Autor:
Yukihiko Hiroshima, Ali Maawy, Yong Zhang, Takashi Murakami, Masashi Momiyama, Ryutaro Mori, Ryusei Matsuyama, Matthew H G Katz, Jason B Fleming, Takashi Chishima, Kuniya Tanaka, Yasushi Ichikawa, Itaru Endo, Robert M Hoffman, Michael Bouvet
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114310 (2014)
The aim of this study is to determine the efficacy of neoadjuvant chemotherapy (NAC) with gemcitabine (GEM) in combination with fluorescence-guided surgery (FGS) on a pancreatic cancer patient derived orthotopic xenograft (PDOX) model. A PDOX model w
Externí odkaz:
https://doaj.org/article/8aea794b47094a889810edfc0c08a743
Autor:
Yukihiko Hiroshima, Ali Maawy, Mohamed K Hassanein, Rhiana Menen, Masashi Momiyama, Takashi Murakami, Shinji Miwa, Mako Yamamoto, Fuminari Uehara, Shuya Yano, Ryutaro Mori, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Yasushi Ichikawa, Michael Bouvet, Itaru Endo, Robert M Hoffman
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103382 (2014)
We previously defined macrophages harvested from the peritoneal cavity of nude mice with subcutaneous human pancreatic tumors as "tumor-educated-macrophages" (Edu) and macrophages harvested from mice without tumors as "naïve-macrophages" (Naïve), a
Externí odkaz:
https://doaj.org/article/ab71c97fab64491aaa690128a0e3a568
Publikováno v:
Oncology Reports
There are conflicted experimental results on the role of bone morphogenetic proteins (BMPs) in cancer. Some results suggest that BMPs act as tumor suppressors while other findings indicate that BMPs are oncogenic factors. In the present study, we aim
Autor:
Armen Gharibi, Jason B. Fleming, Malachia Hoover, Robert M. Hoffman, Alexander Chang, Mark A. Brown, Robert Doebler, Yvess Adamian, Matthew H.G. Katz, Michael Bouvet, Ali Maawy, Jacqueline Lee, Jonathan A. Kelber
Publikováno v:
Oncotarget
Oncotarget, vol 8, iss 4
Oncotarget, vol 8, iss 4
Next-generation sequencing (NGS) can identify and validate new biomarkers of cancer onset, progression and therapy resistance. Substantial archives of formalin-fixed, paraffin-embedded (FFPE) cancer samples from patients represent a rich resource for
Autor:
Yasushi Ichikawa, Takashi Chishima, Yukihiko Hiroshima, Michael Bouvet, Ali Maawy, Yong Zhang, Nan Zhang, Robert M. Hoffman, Takashi Murakami, Kuniya Tanaka, Itaru Endo
Publikováno v:
Oncotarget
Oncotarget, vol 7, iss 44
Oncotarget, vol 7, iss 44
Patient-derived xenograft (PDX) mouse models of cancer are emerging as an important component of personalized precision cancer therapy. However, most models currently offered to patients have their tumors subcutaneously-transplanted in immunodeficien
Publikováno v:
Current Colorectal Cancer Reports. 12:226-231
Approximately 20 % of patients diagnosed with colorectal cancer present with metastatic disease at the time of diagnosis, predominantly to the liver. Surgical resection is the only real chance at a cure for a majority of these patients. A subset of p