Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Ali Khoshnan"'
Autor:
Anjalika Chongtham, Jung Hyun Yoo, Theodore M. Chin, Ngozi D. Akingbesote, Ainul Huda, J. Lawrence Marsh, Ali Khoshnan
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/c6bcdb4a1ddb44878b66ea04652d0e36
Autor:
Anjalika Chongtham, Jung Hyun Yoo, Theodore M. Chin, Ngozi D. Akingbesote, Ainul Huda, J. Lawrence Marsh, Ali Khoshnan
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Changes in the composition of gut microbiota are implicated in the pathogenesis of several neurodegenerative disorders. Here, we investigated whether gut bacteria affect the progression of Huntington’s disease (HD) in transgenic Drosophila melanoga
Externí odkaz:
https://doaj.org/article/f4cf075b3b0a451f98fb0f28d30fa251
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103771- (2022)
Summary: Huntington disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Metabolic changes are associated with HD progression, but underlying mechanisms are not fully known. As the IKKβ/NF-κB p
Externí odkaz:
https://doaj.org/article/0e2914dd1fd24046b864679ec4736f8b
Autor:
Anjalika Chongtham, J. Mario Isas, Nitin K. Pandey, Anoop Rawat, Jung Hyun Yoo, Tara Mastro, Mary B. Kennedy, Ralf Langen, Ali Khoshnan
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105517- (2021)
Huntington’s disease (HD) is a genetically inherited neurodegenerative disorder caused by expansion of a polyglutamine (polyQ) repeat in the exon-1 of huntingtin protein (HTT). The expanded polyQ enhances the amyloidogenic propensity of HTT exon 1
Externí odkaz:
https://doaj.org/article/b14f1f67bf2e4d5bac793d3277f76d60
Autor:
Franziska Schindler, Nicole Praedel, Nancy Neuendorf, Severine Kunz, Sigrid Schnoegl, Michael A. Mason, Bridget A. Taxy, Gillian P. Bates, Ali Khoshnan, Josef Priller, Jan Grimm, Marcel Maier, Annett Boeddrich, Erich E. Wanker
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The deposition of mutant huntingtin (mHTT) protein aggregates in neurons of patients is a pathological hallmark of Huntington’s disease (HD). Previous investigations in cell-free and cell-based disease models showed mHTT exon-1 (mHTTex1) fragments
Externí odkaz:
https://doaj.org/article/39b7832b713b418b99c771d5d66fad70
Autor:
Ali Khoshnan, Paul H. Patterson
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 2, Pp 305-311 (2011)
The IκB kinase β (IKKβ) is a prominent regulator of neuroinflammation, which is implicated in the pathogenesis of Huntington's disease (HD). Inflammatory mediators accumulate in the serum and CNS of premanifest and manifest HD patients, and cytoki
Externí odkaz:
https://doaj.org/article/ac98a0eec6e941dcb75d9dc2ee662195
Autor:
Ali Khoshnan, Paul H Patterson
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41794 (2012)
The IκB kinase α (IKKα) is implicated in the differentiation of epithelial and immune cells. We examined whether IKKα also plays a role in the differentiation and maturation of embryonic human neuronal progenitor cells (NPCs). We find that expres
Externí odkaz:
https://doaj.org/article/239d4280c75145b9bfcbd677ba2c45d8
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5768 (2009)
BACKGROUND:Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD). However, the environmental cues and signaling pathways that regulate Htt proteolysis are poorly understood. One stimulus may be the DNA dama
Externí odkaz:
https://doaj.org/article/745e25ba8b2745289a4c9d20d8c8913b
Autor:
Anoop Rawat, J. Mario Isas, Ali Khoshnan, Jung Hyun Yoo, Tara L Mastro, Nitin K. Pandey, Mary B. Kennedy, Anjalika Chongtham, Ralf Langen
Publikováno v:
Neurobiology of Disease, Vol 159, Iss, Pp 105517-(2021)
Neurobiol Dis
Neurobiol Dis
Huntington's disease (HD) is a genetically inherited neurodegenerative disorder caused by expansion of a polyglutamine (polyQ) repeat in the exon-1 of huntingtin protein (HTT). The expanded polyQ enhances the amyloidogenic propensity of HTT exon 1 (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96340cf87bf4c13192f26cbe7d5b0753
http://www.sciencedirect.com/science/article/pii/S0969996121002667
http://www.sciencedirect.com/science/article/pii/S0969996121002667
Autor:
Ngozi D. Akingbesote, Ali Khoshnan, Jung Hyun Yoo, Ainul Huda, Theodore M Chin, Anjalika Chongtham
Changes in the composition of gut microbiota are implicated in the pathogenesis of several neurodegenerative disorders. Here, we investigated whether gut bacteria affect the progression of Huntington’s disease (HD) in transgenic Drosophila melanoga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b16b4b73774ef7c71270d7a404c42523
https://doi.org/10.1101/2021.08.12.456124
https://doi.org/10.1101/2021.08.12.456124
