Výsledky vyhledávání - "Ali Kh. Khalil"

Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers

Autor: Abeer M. El-Naggar, Ibrahim H. Eissa, Ali Kh. Khalil, Eslam M. Abbass, Mohamed M. Mohamed

Publikováno v: Bioorganic chemistry. 104

As an extension for our earlier effort in the field of discovery of anticancer agents acting on DNA and Topo II, eighteen quinoxaline derivatives were designed and synthesized. Such members were designed to possess the main essential pharmacophoric f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e742222a8f369bd2df5488d2c0a9773
https://pubmed.ncbi.nlm.nih.gov/32927130

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Facile Synthesis of Chalcone Glycosides Isolated from Aerial Parts of Brassica rapa l. ‘hidabeni'

Autor: Galal A. Elsayed, Ali Kh. Khalil

Publikováno v: Current Organic Synthesis. 15:423-429

Background: The Cruciferous family of vegetables which includes Brassica Turnips showed antioxidant and hepatoprotective effects. The phytochemical investigations of the aerial parts of the traditional Japanese turnip vegetable (B. rapa L. 'hidabeni'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3e41898f9c9b704b22f340bc421d646
https://doi.org/10.2174/1570179414666170824161618

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Utility of chloroacetonitrile in construction of some hitherto novel pyrazole and thiazole derivatives

Autor: Hazem Ali Mohamed, Ali Kh. Khalil, Amany I. Raafat, Galal A. Elsayed

Publikováno v: Journal of the Iranian Chemical Society. 15:191-199

2-(-Piperidin-1-yl) acetamide (2) was easily prepared by reacting chloroacetonitrile with piperidine. Furthermore, (2) was allowed to react with different aromatic aldehydes to afford novel arylidene derivatives (3a,b). Unexpectedly, 2-oxo-4-hydroxy-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3b30576a7e2e7e0225fec41df9aa6ad
https://doi.org/10.1007/s13738-017-1223-9

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TD-DFT calculations, NBO analysis and electronic absorption spectra of some thiazolo[3,2-a]pyridine derivatives

Autor: Shimaa Abdel Halim, Ali Kh. Khalil

Publikováno v: Journal of Molecular Structure. 1147:651-667

The electronic structure of thiazolo[3,2- a ]pyridine and some of its derivatives are investigated theoretically using B3LYB/6-311G (d, p) method. The calculations show that all the studied compounds 1 – 5 are non-planar, as indicated from the dihe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59e0e06994e7e896bf6ce361bc803fb3
https://doi.org/10.1016/j.molstruc.2017.06.098

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Design, molecular modeling and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as inhibitors of topoisomerase II

Autor: Wael M. El-Sayed, Ali Kh. Khalil, Souad A. El-Metwally

Publikováno v: Bioorganic Chemistry. 94:103492

Synthesis of 4-(3,5-dimethyl-1H-pyrazol-1-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine 1 and its functionalized reactions as nucleophile with various electrophilic reagents were performed through facile methods to yield different cyclic an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57b0d5e2f5c565c520625a457003ce5
https://doi.org/10.1016/j.bioorg.2019.103492

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Investigation of lipoidal matter of Chenopodium quinoa seeds and its cytotoxicity potential against three human cancer cell lines

Autor: Khaled A. Shams, Nahla S. Abdel-Azim, Rasmia A. Hassan, Ali Kh. Khalil, Ahmed R. Hamed, Faiza M. Hammouda, Ibrahim A. Saleh, Shaymaa M Bata

Publikováno v: Egyptian Pharmaceutical Journal. 19:47

Background and objectives Quinoa (Chenopodium quinoa Willd) is a plant species that belongs to Chenopodiaceae family. It has a high nutritional value as it is rich in proteins, lipids, and fiber, and has an extraordinary balance of essential amino ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::889f8624ff1b7ec67834a41027cb0990
https://doi.org/10.4103/epj.epj_53_19

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Novel Tetrahydrobenzo [b] Thiophene Compounds Exhibit Anticancer Activity through Enhancing Apoptosis and Inhibiting Tyrosine Kinase

Autor: Ali Kh. Khalil, Wael M. El-Sayed, Abeer M. El-Naggar, Souad A. El-Metwally

Publikováno v: Anti-cancer agents in medicinal chemistry. 18(12)

Background: Developing new chemotherapeutic agents with molecular targets, larger margin of safety against normal cells and low cost is the target many scientists try to achieve. Objective: The present study was undertaken to investigate the anticanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9635acf066a280013230912fb4cf07
https://pubmed.ncbi.nlm.nih.gov/30101717

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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME THIAZOLIDINONEDERIVATIVES BEARING PYRIDINE MOIETY: SEARCH FOR ANTIMIROBIAL AGENT

Autor: Hazem Ali Mohamed, Gameel A. M. El-Hag Ali, Ali Kh. Khalil, Hassan A. Eyada, Raafat A. Elisway

Publikováno v: Al-Azhar Bulletin of Science. 25:31-40

2-(4-Oxothiazolidin-2-ylidene)acetonitrile and ethyl -2-(4-oxothiazolidin-2-ylidene)acetate (1a,b),were condensedwith anthralaldehyde(1:1 molar ratio) and gave 4,5-dihydro- 4-oxothiazole derivatives (2a,b).Refluxingof 2-(antharacene-9-yl-methylene) m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76d007259c62aecd8d3f93a6a160101b
https://doi.org/10.21608/absb.2014.23797

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